Liposomes hold great promise for peptide-based personalized cancer vaccination, especially when administered intradermally. However, current liposome preparation methods are very time consuming (resulting in long development times per formulation), whereas personalized cancer vaccination requires very…

Leiden University Medical Center (LUMC) and the Centre for Human Drug Research (CHDR) are taking part in the phase 2 clinical trial of Janssen Vaccines’ candidate coronavirus vaccine. The vaccine will be tested on 45 test participants in Leiden from 14 September onwards.

A coronavirus booster shot provides a better immune response against COVID-19 than a single vaccine dose. mRNA boosters are the most effective upon receiving Janssen. These are the results of a collaborative study between several organisations, including the Leiden University Medical Center (LUMC).…

The Department of Medical Microbiology of Leiden University Medical Centre (LUMC) will investigate the efficacy of a new experimental vaccine from the pharmaceutical company Jansen against the coronavirus. The research is being conducted in collaboration with the The Janssen Pharmaceutical Companies…

The potential of liposomal cancer vaccines

Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.

Atherosclerosis, in particular rupture of atherosclerotic plaques, is the underlying cause of most heart attacks or strokes and is the leading cause of death worldwide.

In this journal article, Dr. Joris Larik and Dr. Richard Ponzio put forward a broad-based pandemic recovery agenda that goes hand in hand with institutional reforms at the global level.

Leiden chemists recreated the bacterial capsule of meningococcus in the lab. With a few modifications, these capsules can serve as an extra safe and effective vaccine against these notorious bacteria, which can cause, for example, meningitis. PhD candidate Jacopo Enotarpi and his team published the…

In the literature, several types of microneedles have been extensively described. However, porous microneedle arrays only received minimal attention. Hence, only little is known about drug delivery via these microneedles. However, porous microneedle arrays may have potential for future microneedle-based…

According to Dutch Prime Minister Mark Rutte, there are currently no plans to introduce mandatory vaccinations in the Netherlands. In surrounding European countries, however, the situation is very different. Professor of Health Law and deputy judge Aart Hendriks: ‘The idea that freedom rights are more…

Mycobacterium tuberculosis (Mtb), the pathogen causing tuberculosis (TB), is the leader among all pathogens responsible for the most human deaths today and it is considered as one of the top 10 causes of death worldwide. There is an increasing occurrence of multidrug-resistant and even totally drug-resistant…

Research by Leiden University Medical Center (LUMC), The Hague University of Applied Sciences and Erasmus University Rotterdam shows that about 15 percent of Dutch people do not want to be vaccinated. If better use were made of the knowledge of local professionals such as GPs, it would be easier to…

Tuberculosis (TB) is a major global health problem caused by the bacterium Mycobacterium tuberculosis (Mtb). In 2015, there were estimated to be 10.4 million new cases and 1.8 million deaths ascribed to TB, making it one of the top 10 causes of death worldwide. Unfortunately, the only current registered…

Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects…

The current hepatitis B vaccines need to be stored and transported under refrigerated conditions (2-8 degrees C). This dependence on a cold-chain is highly challenging in areas where hepatitis B virus infections are endemic.

A vaccine based on sugar coats does have the potential to combat a multi-resistant staphylococcus. That is what Jeroen Codée and his colleagues from Utrecht state in Nature. In doing so, they are contradicting the earlier conclusions of German colleagues.

In this article, the authors summarise the literature on the effects of multilevel governance on governments’ policy responses to Covid-19.

In the wake of the COVID-19 pandemic, the pressing question is how this global health emergency impacted the research agendas of the field of crisis and disaster science. This article reviewed contributions in ten important crisis and disaster journals in the two and a half years following the COVID-19…

Microneedles are a promising tool for the painless administration of vaccines through the skin. But, are these minuscule needles really effective? PhD student Pim Schipper of the Leiden Academic Centre for Drug Research investigated various factors of vaccination via the skin and discovered, among other…

The quality of vaccines is still often tested by using laboratory animals. That has to change, according to researchers from Leiden University and the vaccinological institute Intravacc. Together they went searching for a test method that makes animal testing unnecessary. The first promising results…

Maria Yazdanbakhsh, Professor of Parasitology at the Leiden University Medical Centre (LUMC), has been awarded an ERC Advanced Grant of 2.5 million euros. She will investigate why people in Africa and Southeast Asia respond less to certain vaccines than Europeans. Her goal is to find a solution for…

In this opinion article published in World Development, the authors present five research and policy priorities. While it is clear that ‘pluriversal’ designs need to guide the way forward (Kothari et al 2019), defining a set of key pillars can provide direction and purpose across this pluriversality.…

The current COVID-19 vaccination campaign involves injecting the vaccine into muscle tissue, but injecting a smaller amount of vaccine in the skin might also provide good protection. The #wakeuptocorona crowdfunding campaign has enabled Anna Roukens (LUMC) to examine the safety and efficacy of vaccination…

Now the number of people with COVID-19 is increasing and we are faced with stricter measures once again, the question arises whether compulsory vaccination could be allowed.

VODAN Africa started as a platform to enable access to critical data needed from Africa to fight the novel COVID-19. The initiative was inspired by the experience from the Liberia Ebola Virus outbreak in 2014: early detection requires contact tracing. Inclusion of the most vulnerable is critical to…

The corona crisis is also a disinformation crisis for the global community in general, and for the European Union (EU) in particular. What is less clear is how adequate the EU’s response to the ‘infodemic’ has been. This essay exposes the dangers of disinformation for the EU, which have intensified…

The coronacrisis makes painfully clear that a transboundary crisis requires a transboundary response. The European Union could play a key role, but that has not happened so far. Political scientist Amy Verdun (Leiden University) explains why.

The coronacrisis is emerging as the ultimate test for political leaders. How do national political leaders get ahead or behind ‘the curve’ of fast-changing dynamics. Martin Lodge (London School of Economics and Political Science) and Arjen Boin (Leiden University Institute of Political Science) look…

This study aims to examine how South Korea (hereafter, Korea) and Japan, two neighboring countries in Northeast Asia, have been responding to and mitigating the spread of COVID-19.

For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…

This collection, edited by Sophie Vériter, Monica Kaminska, Dennis Broeders and Joachim Koops, includes six papers exploring and investigating European responses to COVID-related disinformation, specifically the responses of France, Sweden, Germany, the United Kingdom, Serbia, and Hungary.

This paper written by Vydra and Kantorowicz answers the research question ‘What policy-relevant information does Twitter contain?’ as well as the research question ‘How does this information change between a period of normalcy and a period of crisis?’

The shift from response to recovery is now noticeable as the world moves past the paralyzing effects of the COVID-19 pandemic. This book explores responses to the pandemic by international, regional, and local institutions, multilateral action, and crisis prevention efforts at different levels of governance,…

How do governments distribute resources across economic sectors during a crisis? And why do some sectors receive more than others? The recent COVID-19 pandemic has highlighted the urgency of these questions. In this paper, we explore the extent to which a political economy…

How can Europe lead the way in vaccine development that is fast and for all? To answer this pressing question, Professor of Vaccinology Meta Roestenberg is holding a panel session on 14 July at the EuroScience Open Forum in Leiden.

If it’s up to PhD student Guangsheng Du, patients don’t need to worry about big needles anymore. At the Leiden Academic Center for Drug Research (LACDR), he studied the use of microneedles and nanoparticles as a new vaccination system. ‘I want to create a more patient-friendly delivery method.’ He defends…

Ontwikkelen van een vaccin tegen aderverkalking

In this article, Yannick Veilleux-Lepage and Tommy van Steen, assistant professors at the Institute of Security and Global Affairs, discuss the degree of consensus within the field of terrorism studies regarding the impact of the COVID-19 pandemic on the activities of violent non-state actors.

This study looks at population response to government containment strategies during initial stages of the COVID-19 pandemic in four high-trust Northern European countries–Denmark, Germany, the Netherlands, and Sweden–with special emphasis on expressions of governmental trust.

Leiden researchers have carried out successful tests using a new method of packaging a cancer vaccine in nano-particles. The new vaccine has induced a strong immune reaction in mice. The researchers believe that this method can make an important contribution to the treatment of cancer. Their findings…

The research of the Biotherapeutic Delivery group led by Joachim Van Guyse focuses on developing novel polymer-based formulations for therapeutic nucleic acid and protein delivery. The research revolves around developing structure-activity relationships between the chemical structure of polymers, the…

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

Researchers at Leiden University Medical Center (LUMC) and Radboud university medical center have been given the green light to deliberately infect volunteers with malaria in order to test a highly promising vaccine on them.