Promotores: J.N. Kok, H.J. Hoogeboom

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

How do protein modifications work together to repair DNA, and what can we learn about these interactions to better understand disease?

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

Promotor: R.D. Gill, F. Taroni

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Thirty years ago, mutations in the BRCA1 gene were first linked to hereditary breast and ovarian cancer, establishing a genetic basis for cancer development.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Promotor: Prof.dr. J.N. Kok, Co-promotor: Dr. A.J. Knobbe

What is the most effective way to eliminate tumour cells? The DNA repair mechanism could play an important role in increasing the effectiveness of chemotherapy in the fight against cancerous cells. If we are to influence this mechanism, we need fundamental knowledge about how the mechanism works.

Curious about how sustainability fits into our university's strategic plan, or how much energy and water we consume? Read about it here.

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Local authorities face numerous major issues in different neighbourhoods, all requiring different approaches and solutions. With this study, Leiden University aims to gain a better understanding of how residents from every neighbourhood in The Hague think and act on such issues. This insight will help…

The European Homicide Monitor (EHM) offers a standardized framework for countries and regions to compare homicide characteristics, patterns and trends.

Across Europe, the need for a more dynamic governance and a better societal integration of research and innovation is increasingly appreciated. Internal drivers of change (such as the digitalization of science) and political will to better align with societal needs and concerns are bringing about aspirational…

Organized by the GSA, all PhD candidates undergo a personal progress interview known as the Monitoring Meeting. Internal PhD candidates have the Monitoring Meeting annually, while external PhD candidates have it every two years.

The Children’s Rights Monitor provides a thematic overview of the implementation of the UN Convention on the Rights of the Child in the Netherlands.

The Children’s Rights Monitor provides a thematic overview of the implementation of the UN Convention on the Rights of the Child in the Netherlands.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

The Children’s Rights Monitor provides a thematic overview of the implementation of the UN Convention on the Rights of the Child in the Netherlands.

Every PhD candidate draws up a Training and Supervision Plan (TSP; in Dutch: Opleidings- en Begeleidingsplan, OBP) with their supervisors within three months after the start of their project. This TSP contains agreements relating to the design and planning of the project, the form and frequency of supervision,…

Over the next two years, CWTS and Dialogic will develop a robust and context-specific monitoring and evaluation framework for Open Science in the Netherlands. This will be accompanied by the development of a prototype dashboard to showcase how such an Open Science monitor could be made visible.

This project’s aim is to critically assess current homicide data sources in order to develop a proposal for long-term EU-level monitoring of DRH.

The aim of this study is to further develop the Open Science Monitor, which started as a pilot study.

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Animal diet studies are critical for understanding ecological processes such as trophic interactions, energy flow, and nutrient cycling. By examining what animals consume, ecologists gain insights into species specialization, predator-prey relationships, and ecosystem management.

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

The SPS Monitor measures your sensory stimulus sensitivity. Sensory stimulus sensitivity refers to one's sensitivity to subtle environmental stimuli, the depth and intensity with which these stimuli are processed and the impact this has on one's functioning.

Leiden physicist Maarten Kruithof has discovered how our DNA is infallibly able to fold itself and to unfold again. In his dissertation he demonstrates how DNA is folded in a single long, very flexible spiral.

Single-celled organisms have stiffer DNA than multicellular lifeforms like humans and rice. Theoretical physicists managed to simulate the folding in full genomes for the first time to reach this conclusion. Publication in Biophysical Journal on February 7.

Kim de Jong, Jaime Delgadillo, and Michael Barkham offer valuable insights in their book 'Routine Outcome Monitoring and Feedback in Psychological Therapies' on how therapists and trainees can use feedback to inform treatment decisions and, ultimately, enhance patient outcomes.

Comparison across jurisdictions is one way of assessing the appropriateness of lethal force resulting from the actions of law enforcement agencies. This article sets out a vision for a global use of force monitor that can enable meaningful comparisons between law enforcement agencies. It examines some…

Promotor: Prof.dr. F.S. de Boer

Theoretical physicist Helmut Schiessel receives an NWO Projectruimte grant of 390,000 euro. He will use this budget to hire a postdoc and a PhD student to continue his research on flexibility of double stranded DNA.

In an Advance Online Publication biophysicist John van Noort and others show using magnetic tweezers that DNA is folded in compliant helices of chromatin. This allows enzymes access to the DNA needed for gene expression. Van Noort's research group made the discovery in close partnership with researchers…

Researchers from Biomon have used DNA-techniques to find 40 different species of fish in the river Dommel. This technique is capable of detecting more species than conventional methods of measuring.

PhD defence

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Dutch researchers have developed a new tool to label DNA for studying chromosomes in live cells. The tool is non-invasive and can be applied in culture but also in living organisms, such as zebrafish embryos. The team published their findings in the journal Nucleic Acids Research.

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

CML report 192

Students with learning problems experience difficulties in reading, writing, and content-area learning into and throughout their secondary-school years

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

How does the vision of problems and solutions from