854 search results for “antibiotic resistance” in the Public website
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Disentangling drought-responsive traits with focus on Arabidopsis
In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…
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“You cannot predict the future, but you can think about it!” Master’s Vitality and Ageing visits Vilans!
As part of the career orientation of the Master’s Vitality and Ageing, students visit various healthcare, policy and research organisations throughout the year. Students get introduced to relevant organisations where they have the possibility for a graduation internship and career opportunities. This…
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Awards and Grants 2022
An overview of awards and prizes granted to our staff and students in 2022, as well as special appointments at Leiden University and other institutions.
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New imaging technology to assess early drug success
Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…
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Vertical interventions? The local politics of migration management and policing in intra-Schengen borderlands
What is the role of local authorities and communities in shaping how inter-Schengen borders are understood and dealt with?
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Scientists find strong evidence that wasting syndrome is the same for all organisms
An interdisciplinary team of Leiden researchers has discovered that wasting syndrome, a severe byproduct of tuberculosis, is the same for all humans and animals studied. The discovery offers new opportunities to investigate the still insufficiently understood condition. The scientists also developed…
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Leiden2022
Leiden was European City of Science in 2022: for a year Leiden was the capital of European science. Leiden University was a proud partner of Leiden2022.
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Growth and Transport properties of (Rare Earth)TiO3 / SrTiO3 interfaces
This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.
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Green defense against thrips- Exploring natural products for early management of western flower thrips
As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).
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Disrupted movement makes macrophages more lethal to tuberculosis bacteria
Macrophages – the front line of our immune system – protect us from infections. But in the case of the tuberculosis bacteria, this often goes wrong. The group of Annemarie Meijer from the Leiden Institute of Biology has now discovered that macrophages in zebrafish are better able to eliminate tuberculosis…
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Participants
The CMCB comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC) and the Leiden University Medical Center (LUMC).
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It’s all about the cell wall for brand-new professor Dennis Claessen
Dennis Claessen has been appointed professor of Molecular Microbiology at the Institute of Biology Leiden. With his teaching and research on the cell wall, the professor wants to establish applications in the industry and the medical sector.
- News
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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Medical Delta professor Ariane Briegel: 'I love working with people from different backgrounds'
Multidrug-resistant pathogens and worldwide pandemics are increasing, making infectious diseases more prevalent. To develop new treatments, deeper knowledge of the interaction between bacteria and human cells is required. Ariane Briegel recently became a Medical Delta professor and studies such path…
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A synthetic vaccine against meningococcus
Leiden chemists recreated the bacterial capsule of meningococcus in the lab. With a few modifications, these capsules can serve as an extra safe and effective vaccine against these notorious bacteria, which can cause, for example, meningitis. PhD candidate Jacopo Enotarpi and his team published the…
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Heterogeneity in spores of food spoilage fungi
This project intends to provide the required knowledgebase for the design of novel mild intervention protocols to prevent fungal food spoilage.
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Neske Baerwaldt
Faculteit Rechtsgeleerdheid
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The impact of defense hormones on the interaction between plants and the soil microbial community
The soil ecosystem consists of the largest reservoir of biodiversity on Earth.
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Analysis of the angucycline biosynthetic gene cluster in Streptomyces sp. QL37 and implications for lugdunomycin production
Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.
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Faculty of Science opens academic year with responsibility call and nanoparticles
On Tuesday 4 September, in a full lecture hall C1, Dean Geert de Snoo opened the Academic Year for the Faculty of Science. A year in which the ethics and responsibility of scientists will be invoked.
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NWO grants two IBL-proposals by interdisciplinary research consortia
Recently, NWO has decided to grant two interdisciplinary research proposals for national and international consortia submitted by researchers from the Institute of Biology Leiden. One of the proposals is led by Prof. dr. Ariane Briegel, the other one by dr. Remko Offringa.
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Four Leiden consortia awarded large NWO grants
No less than four Leiden research teams have been awarded a grant by NWO. On 27 July NWO honoured 21 applications in the Open Competition ENW-XL. NWO awards the grants to consortia in the exact and natural sciences who are doing unconnected fundamental research that is 'driven by curiosity'.
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Mosaic subsidies for highly talented ethnic minority researchers
Four of Leiden's young, talented ethnic minority graduates are to receive an award as part of the Mosiac programme of the Netherlands Organisation for Scientific Research (NWO). The award will allow these budding researchers to fund a four-year research period leading to a doctorate.
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Antibiotica Scavenger Hunt
Speurtocht
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LED3 Lecture: Natural Product Antibiotics: Past, Present, Future
Lecture
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Manipulating plant metabolomic profiles by seed and plant cutting treatments to enhance plant protection against western flower thrips
How can we manipulate the biotic and abiotic environment to increase thrips resistance in tomato and chrysanthemum? More specifically we ask: How can plant secondary metabolites that are not soluble in water be delivered to plants in seed coating or root dipping treatment? Can bacteria be used to…
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National Meat Free Week: the main reasons to switch to a plant-based diet
National Meat Free Week (Nationale Week Zonder Vlees, 7–13 March) is an initiative to reduce meat consumption. Assistant professor Paul Behrens is studying what impact a change in our food consumption would have on the world. What, according to him, are the main reasons to switch to a (mainly) plant-based…
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Peter Bouwman
Science
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Babak Rezaeedaryakenari
Faculteit der Sociale Wetenschappen
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Key publications
Key publications of the Antiviral Pharmacology group.
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Quantitative pharmacology approaches to inform treatment strategies against tuberculosis
Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.
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A clear picture of bacteria
Freezing bacteria super fast to gain a true-to-nature image of the internal and external structure. Ariane Briegel Professor of Ultrastructural Biology came to Leiden specially to carry out this research. Leiden University is one of the few institutes in the world to have the necessary equipment. Inaugural…
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A lifeline for Leiden research – TB solution a step closer thanks to this Indonesian university
Herman Spaink knows of many substances that may help combat tuberculosis. Lab space to study them safely is very limited in Leiden. A brand-new lab at Universitas Gadjah Mada in Indonesia will soon provide a solution. About time, says Spaink, ‘The disease is on the rise and is becoming less sensitive…
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The ecological relevance of chemical diversity in plants: pyrrolizidine alkaloids in Jacobaea species
Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder
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Microbiome-mediated colonization resistance: defense against enteropathogens and multi-drug resistant organisms
PhD defence
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Coiled-coil biomaterials for biological applications
This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.
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Research
Our research examines mental health risk and resilience in young people. We do so by integrating cultural, social, cognitive and neurobiological factors and their interactions.
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World War II
In 1940 the Germany occupiers ordered the dismissal of all Jewish staff of the university. This resulted in protest speeches by fellow academics.
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Cleaning up tuberculosis and salmonella infections
The cellular recycling system in zebrafish is capable of eating harmful bacteria and thus resist infections such as tuberculosis and salmonellosis. That is written by Leiden biologists from the group of Annemarie Meijer. Stimulating this form of defence could be used in new treatment methods against…
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Staphylomics: Identifying host factors involved in staphylococcal infection
How can Staphylococcus aureus bacteria subvert the host immune system?
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Small-molecule inhibitors of bacterial metallo-β-lactamases
The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).
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Cancer Drug Target Discovery
We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.
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Figuring Things Out Together: On the Relationship Between Design and Collective Practice
Anja Groten investigates matters of collectivity, drawing from the experience of working with the Amsterdam-based collective Hackers & Designers (H&D)*.
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Development of an intradermal tuberculosis vaccine by combining dissolvable microneedle arrays and Mycobacterium tuberculosis antigen-containing
Mycobacterium tuberculosis (Mtb), the pathogen causing tuberculosis (TB), is the leader among all pathogens responsible for the most human deaths today and it is considered as one of the top 10 causes of death worldwide. There is an increasing occurrence of multidrug-resistant and even totally drug-resistant…
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Kemalism in the periphery: anti-veiling campaigns and state-society relations in 1930s Turkey
This dissertations studies state-society relations in 1930s Turkey, focusing on the anti-veiling campaigns in the mid-1930s and aiming to understand the ways in which the Kemalist policies were received, interpreted, negotiated, compromised and/or resisted by various actors in the provinces.
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PhD candidate: HiTaL: High Throughput Anisotropic Lithography
Science, Leiden Institute of Physics (LION)
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Chao Du
Science
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Glucocorticoids in zebrafish
A novel in vivo model system for studies on glucocorticoid resistance
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Eight researchers to travel abroad on Rubicon grant
Eight young researchers from Leiden University have received a Rubicon grant from the Dutch Research Council (NWO). This will allow them to conduct research at a top institute or university abroad.