2,690 search results for “development 26 disease” in the Public website
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Bòsò Walikan Malangan: Structure and development of a Javanese reversed language
On the 24th of October, Nurenzia Yannuar successfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Nurenzia on this achievement.
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Lessons from Rare Diseases
PhD defence
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Focus on kinetics for better drug development
Potential drugs that seem promising in the lab, but don’t show any activity in a person: they cost the industry an incredible amount of time and money. That’s why Indira Nederpelt focuses on a more efficient search for new drugs in her PhD, by determining the kinetics of a potential drug earlier on…
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Information activities
Do you want to know more about Cultural Anthropology and Development Sociology and what it is like to study in Leiden? Come to our online or on campus information events.
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Research projects
An overview of research projects at the Predictive Pharmacology group.
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The development of molecular tools for investigating NAD+ metabolism and signalling
Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…
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Development of cross-protective influenza A vaccines based on cellular responses
Seasonal influenza vaccines provide protection against matching influenza A virus (IAV) strains mainly through the induction of neutralizing serum IgG antibodies. However, these antibodies fail to confer a protective effect against mismatched IAV. This lack of efficacy against heterologous influenza…
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…
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ImBod | Embodied Imamate: Mapping the Development of the Early Shiʿi Community 700-900 CE
Imami Shiʿism was a key part of the turbulent thesis and antithesis which formed Islam, and it remains greatly influential today. The aim of the ImBod project is to write the first comprehensive social history of the Imamate.
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of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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Dr. Kiefte-de Jong and Dr. Bosker, Assistant Professors at LUC, both awarded LUF Awards
Dr. Jessica Kiefte-de Jong and Dr. Thijs Bosker, both Assistant Professors at LUC, have been awarded by The Leiden University Fund (LUF).
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Zebrafish personality, stress physiology and behaviour in the context of sound exposure
To what extent is sound a stressor to fish? And are behavioural and physiological phenotypes equally sensitive to disturbance by noise pollution?
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Why don't drugs make it to the market?
How can we extend the drug residence time to combat diseases more effectively?
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Vertebrate automated screening technology (VAST)
How can you use robots and automatic recognition of microscopic images to test the effect of drugs exceptionally quickly?
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Aging and Immunity
The Aging and Immunity group is led by Dr. Amanda Foks. In this group we aim to investigate how aged immune cells contribute to atherosclerosis and identify novel therapeutic targets and strategies to extend health span and inhibit cardiovascular disease.
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Azafaros is valorizing a library of compounds
The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Chemical biology of sphingolipids: fundamental studies and clinical applications
Overkleeft
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CoSTREAM: Understanding Stroke and Alzheimer
The Horizon 2020 project CoSTREAM aims to improve our understanding of the co-occurrence of stroke and Alzheimer’s disease. It has long been known that both diseases share underlying causes, but their exact interaction or link is not fully understood. CoSTREAM combines multiple factors to identify and…
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Rational Design of Athero-Protective Vaccines; Novel Vaccine Formulations and Alternative Routes of Administration
Atherosclerosis is a chronic inflammatory disease affecting millions of people world-wide.
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Novel approaches to develop filamentous micro-organisms for enzyme production (FILAZYME)
Can we develop new enzymes and cell factories to upgrade current enzyme cocktails towards complete degradation of biomass?
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Development of a universal delivery system for tailor-made cancer vaccines
The potential of liposomal cancer vaccines
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Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.
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Religion, Class, and the Postwar Development of the Dutch Welfare State
Religion, Class, and the Postwar Development of the Dutch Welfare State. Dennie Oude Nijhuis.
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European foreign policy in times of crisis: a political development lens
EU foreign policy has become increasingly politicised over the past years, amongst others as a consequence of the succession of crises. Crises may engender processes of crisis framing and contestation. This article focuses on how the policy demands being voiced in these processes of contestation are…
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Profile 6. Developing a parcel based historical GIS of the Netherlands
Historical geo data are gaining in importance. Provided that they are exactly geo referenced, they can be stored into a GIS and thus be combined with all kinds of maps (topographical, pedological, etc.) and datasets. This makes it possible to analyze historical developments in space and time on a detailed…
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Microbes protect crops from microbes
Farmers do not love them all. Microbes can cause tragic consequences for crops. Even the presence of just one pathogenic fungus or bacterium can drastically reduce yields. Still, there are exceptions. In that case, a pathogenic microbe is present in the soil, but does not cause any harm. Adam Ossowicki…
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Research
Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…
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Drug development: how can we make it more efficient?
It takes years to develop new medicines, from the test tube to trials in humans. During the process it often happens that a drug that seems promising in the initial stage has to be dropped in a later phase. This costs time and money. Leiden University and the LUMC are working closely together to make…
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Ayokunu Adedokun
Faculty Governance and Global Affairs
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Rizal Shidiq
Faculty of Humanities
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Jacqueline Vel
Faculteit Rechtsgeleerdheid
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Carolien Rieffe
Faculteit der Sociale Wetenschappen
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Sjoerd Lopik
Faculteit Rechtsgeleerdheid
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Merijn de Bakker
Science
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Jonathan Phillips
Faculteit der Sociale Wetenschappen
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Stephanus Huijbregts
Faculteit der Sociale Wetenschappen
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Joost Visser
Science
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Jochanan Veerbeek
Faculteit der Sociale Wetenschappen
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Horst Fischer
Faculteit Rechtsgeleerdheid
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Paul van den Broek
Faculteit der Sociale Wetenschappen
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Xiaoyang Zhong
Science
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Jan Michiel Otto
Faculteit Rechtsgeleerdheid
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Maximilian König
Faculteit der Sociale Wetenschappen
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Bert Koenders
Faculty Governance and Global Affairs
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Lina van Drunen
Faculteit der Sociale Wetenschappen
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Alette Vonk
Faculty of Humanities
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The historical development of the Dutch posture-verb progressive construction
On the 22nd of February, Ami Okabe successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Ami on this achievement!
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Development of a Transgenic Mouse Model to Study the Immunogenicity of Recombinant Human Insulin
Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…
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T-CYCLE EPR: Development at 275 GHz for the study of reaction kinetics & intermediates
A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.