Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

The European Research Council (ERC) has awarded chemist Dr Alexander Kros a Starting Independent Researcher Grant of 1.4 million euro. He will be using the grant to study how molecules penetrate the natural barrier of a cell membrane. If his research is successful, it will in time bring about a revolution…

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

Promotor: A. Kros

Is there a sufficiently large market for drug screening and testing in Zebrafish larvae using membrane fusion?

This dissertation provides a novel perspective on the interaction between quantifier scope and ellipsis. It presents a detailed investigation of the scopal interaction between English negative indefinites, modals, and quantified phrases in ellipsis. One of the crucial observations is that a negative…

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Alexander Kros studies supramolecular systems in a biological environment. The unifying theme between the projects in my lab is specific molecular recognition, i.e. the intermolecular interaction between complementary molecules with high affinity and selectivity. Studying, imitating and dissecting processes…

New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Many biological processes occur by biomolecules coming together and organizing into specific clusters without being bound to each other. These interactions range from clustering, transiently interacting (kiss and run), or assembling to multimeric units that can only function in conjunction. The hydrogen…

A plasma is an ionized gas with very low electrical resistivity. As such, magnetic field lines are 'frozen in' and move with the fluid. Magnetic field lines that are linked, knotted and tangled, cannot be undone by the fluid motions.

In the Research in Bio-Pharmaceutical Sciences specialisation you will perform research on various topics in the area of Drug Discovery and Development. The programme offers a high level of flexibility and can be tailored to your scientific interests. The major research project is hosted by the Leiden…

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

Where does the urge to collect come from? What are the explicit or underlying reasons for gathering large amount of objects?

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.

Arts and leisure, Arts and leisure

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.

How can sustainable and circular decision-making be integrated into manufacturing operations? How can data from physical simulation models, digital twins and operations be used for sustainability assessment? How can manufacturing decisions affecting sustainability and circularity be integrated into…

Influenza CD8(+) T-cell epitopes are conserved amongst influenza strains and can be recognized by influenza-specific cytotoxic T-cells (CTLs), which can rapidly clear infected cells. An influenza peptide vaccine that elicits these CTLs would therefore be an alternative to current influenza vaccines,…

Arts and leisure, Arts and leisure

Arts and leisure, Arts and leisure

Arts and leisure, Arts and leisure, Arts and leisure

This project will construct an inventory of possible conceptions of the resistance of the world to scientists’ claims and theories.

Arts and leisure, Arts and leisure

Research at the SBC group is comprised of the following research themes:

Our library contains around 23,000 books, journals and historical documents under the care of a specialized librarian.

Physicist Christopher Berg Smiet, who recently obtained his PhD in Leiden, has been awarded an NWO Rubicon. The grant allows him to conduct postdoctoral research for two years at the Princeton Plasma Physics Laboratory (PPPL) in the United States.

A novel in vivo model system for studies on glucocorticoid resistance

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

We would like to present to you a simple guidebook about living a sustainable life as a student in the cities of Leiden and The Hague. Whether you are a first-year student still trying to find your way around or already doing your masters – students wanting to explore more sustainable options and save…

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

Social science research helps us understand human behaviour and social structures. These are determined by various factors, which makes the research complex and increases the likelihood of drawing the wrong conclusions. The choice of research method and analysis is therefore extremely important. It…

The master’s programme Physics at Leiden University offers a wide range of specialisations from theoretical research to cosmology. You will be trained for a career in research or for a more practical-oriented specialisation. The programme offers a wide choice of individual study paths that take into…

Leiden University professor of Science-Based Business Simcha Jong Kon Chin has been awarded an ERC Consolidator Grant.

Christopher Berg Smiet, who defended his thesis at LION with Dirk Bouwmeester, won the Christiaan Huygens prize for his thesis '‘Knots in Plasma’. On 7 October, he received a certificate, a bronze statuette and ten thousand euros.

Leiden University computer scientists Yu Liu, Yanming Guo and Michael Lew are a step closer to their ultimate goal: search engines with visual recognition. Their publication of a new algorithm for fusing multi-scale deep learning representations has been received with great enthusiasm. No other algorithm…

Media Technology MSc student Michael "Mikkel" Olthof shows his work "Curved Sounds" at the Highlight Delft 2024 Festival. The project was made for the course "Sound, Space & Interaction".

The doors of the new Gorlaeus Building are officially open! With an additional lab wing, new lecture halls and offices, a library, a brasserie, and spaces for student associations, the building offers a vibrant and inspiring environment for research, study, and social interaction. Explore on your…

Unravelling networks of human mobility and exchange of goods and ideas from a pre-colonial, pan-Caribbean perspective

The channel through which two cell components exchange material appears to form at the edge of their contact surface, and not in the middle. This was discovered by the Leiden physical chemists Jelger Risselada and Edgar Blokhuis together with researchers from the University of Lausanne in Switzerland.…

Electrons that spin synchronously around their axis, turn out to stay superconducting across large distances within magnetic chromium dioxide. Electric current from these electrons can flip small magnets, and its superconducting version could form the basis for a hard drive without energy loss. Publication…