In the master’s specialisation Molecular Genetics and Biotechnology at Leiden University students are trained by experts in the areas of molecular biology, microbiology, plant genetics, cellular imaging, animal disease models, and various –omics technologies and the corresponding bioinformatics.

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Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

How does invasive hybridization affect threatened native species?

In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…

How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?

Investigating neurobiological endophenotypes of Social Anxiety Disorder

This thesis introduces the concept of

Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Are traces of fire use detectable in ancient hominin genomes?

Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…

This study analyses the prehistory of a northeastern Siberian population, the Sakha, from both a molecular-genetic and a linguistic perspective.

Chemistry is all around us: from nutrition and smartphones to medicine. The field is developing rapidly, as the world population continues to grow and resources become scarce. MST will educate you on the basics of working towards a clean and healthy world.

Promotor: Prof.dr. G.R. de Snoo

This programme video is presented in Dutch

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

In this project, we will study the genetic and environmental drivers of woodiness and stem lignification at the level of plant‐to‐gene‐to‐molecule.

The applications of studying the early development of insects range from agriculture to material science.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

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The master's specialisation Molecular, Cellular and Organismal Biology at Leiden University examines the molecular mechanisms underlying health and disease and how cells and organisms adapt to environmental factors.

The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

In this thesis, I investigated the neurogenetic properties of Neotropical bat species. Bats represent the second largest mammalian order (Chiroptera) in the world, with Neotropical bats constituting about 13% of the total number of bat species.

The specialisation consists of 120 European Credit Transfer System (EC) points and includes courses and electives (30 - 60 EC) and and one or more research projects (60 - 90 EC).

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

Promotor: P.M. Brakefield

In light of climate change, it is crucial to determine whether plant species can adapt to future climates to avoid extinction. Plants adapt to various conditions by altering their functional traits, such as leaf size or photosynthetic rate. Some traits appear linked and vary together between species,…

How do genetic and environmental factors make us vulnerable to depression?

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

Engineering an efficient microbial enzymatic polyethylene degradation pathway via an innovative combination of biochemistry and computational biology tools for enzyme discovery and characterization.

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

The Biology programme offers 4 research-oriented specialisations corresponding with the research themes within the three institutes involved. You can choose a more practical-oriented specialisation if you would like to combine Biology with education, management business, or science communication.

Develop a prototype combined chemical-microbial enzymatical process for the sustainable, green recycling and revalorization of polyamides and polystyrene

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

Lecture

To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…