10,000 search results for “leiden” in the Public website
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Severe behavioral and emotional problems, special education and youth care
Which educational and child welfare interventions offer optimal opportunities for positive development to children with severe behavioral and emotional disorders.
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Transforming Wayang For Contemporary Audiences: Dramatic Expression in Purbo Asmoro’s Style, 1989-2015
Kathryn Emerson defended her thesis on 28 June 2016
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Body and Ki in GiCheon: Practices of Self-Cultivation in Contemporary Korea
Yeonhwa Jeon defended her thesis on 6 July 2017.
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A Brief History of Islam in Europe
Thirteen Centuries of Creed, Conflict and Coexistence
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Smoothly breaking unitarity : studying spontaneous collapse using two entangled, tuneable, coherent amplifiers
The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.
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Développement phonético-phonologique en fulfulde et bambara d’enfants monolingues et bilingues : étude du babillage et des premiers mots
Cette étude montre que le développement phonético-phonologique en fulfulde et bambara est à la foiscomparable au développement langagier dans d’autres langues du monde et influencé par les caractéristiques phonétiques et phonologiques de ces deux langues notamment au niveau de la phonotaxe.
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Guidance documents of the European Commission in the Dutch legal order
On 11 February 2020, Clara van Dam defended her thesis 'Guidance documents of the European Commission in the Dutch legal order'. The doctoral research was supervised by Prof. W. den Ouden and Prof. J.E. van den Brink (UvA).
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Mining the kinematics of discs to hunt for planets in formation
Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…
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The Proliferation of Dissenting Opinions in International Law
On 8 July 2020, Andres Sarmiento Lamus defended his thesis 'The Proliferation of Dissenting Opinions in International Law'. The doctoral research was supervised by Prof. L.J. van den Herik and Prof. Y.A.A.S. Radi (UCLouvain).
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From Technological Humanity to Bio-technical Existence
Explores the relationship between technics and humanity, tracing the emergence of a bio-technical conception of existence in contemporary continental philosophy. Suny Press
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Data Centres for Natural Recources and Products
Creating information portals for support of European environmental policy.
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Bakti and Sayan traditions among the Tenggerese people in East Java: the role of indigenous institutions in integrated elderly care development
This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…
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Dynamic hydrogels as synthetic extracellular matrices for three- dimensional cell culture
Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Phenoconversion
Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…
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Management Team
The IBL management team consists of the Director of the Institute, the Director of Education, the Coordinator Microbial Sciences, the Coordinator Plant Sciences, the Coordinator Animal Sciences, the Institute Manager and the Management Assistant.
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Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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Matching, entropy, holes and expansions
In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.
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Electrocatalytic CO2 reduction toward liquid fuels : on heterogeneous electrocatalysts and heterogenized molecular catalysts
With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.
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Laboratory studies of Water Ice in Space
Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.
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"Normal" Feelings in "Abnormal" Worlds, On the Political Uses of Emotion in Science Fiction Manga
Carl Li defended his thesis on 30 June 2015
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Aquatic eDNA: Beyond Species Presence
As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.
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Dynamic biogeography – Hybrid zone movement
Does a moving hybrid zone leave a genomic footprint?
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Shy parent, shy child?
Delineating psychophysiological endophenotypes of social anxiety disorder
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Social Dimensions of Crane and Wetland Conservation in African Rural Landscapes: Insights from Kenya, Uganda and Zimbabwe
This thesis focuses on the social dimensions of crane and wetland conservation in rural landscapes in Kenya, Uganda and Zimbabwe.
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Science teachers' knowledge development in the context of educational innovation
The research reported in this thesis is concerned with the knowledge development of a small sample of experienced science teachers in the context of a broad innovation in Dutch secondary education, including the introduction of a new syllabus on Public Understanding of Science.
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Towards a single-molecule FRET study of Frauenfelder's nonexponential rebinding of CO in myoglobin
Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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The town, its waste and the cesspit
The rise and fall of the cesspit in an urban context
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Modeling interactions to unravel biomarkers for disease progression and treatment response
The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets
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Project schedule
The area will undergo major changes, in a phased plan. Teaching will continue during this period. The existing education buildings will be tackled one by one. Some of the buildings will be reconstructed, and for others the building shell will undergo renovation. The Humanities Building is expected to…
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Chinese Final Particles and the Syntax of the Periphery
In this research, for the first time a detailed description as well as systematic and comparative analysis of the final particle system in Chinese are provided.
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How Terror Evolves: The Emergence and Spread of Terrorist Techniques
This book contextualizes the use of terror as part of wider movements of political contention, demonstrating that terroristic innovation occurs as part of wider historical processes rather than in a vacuum.
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A blessing in disguise?! Discretion in the context of EU decision-making, national transposition and legitimacy regarding EU directives
This dissertation looks into the role of discretion granted by EU directives (Article 288 Treaty on Functioning of the European Union) in legislative decision-making and national transposition processes of these directives.
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A Grammar of Tagdal
On the 21st of September, Carlos Benítez-Torres successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Carlos on this achievement!
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Structural Properties of Single Server Queueing Systems: Efficient Methods via Lumping and Dynamic Programming
This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.
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The Layered Heart: Essays on Persian Poetry, A Celebration in Honor of Dick Davis
The Layered Heart : Essays on Persian Poetry is published in celebration of the poet and scholar Dick Davis, dubbed “our pre-eminent translator from Persian” by The Washington Post.
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Multi-objective mixed-integer evolutionary algorithms for building spatial design
Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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Identifying the origins of galaxy formation
This thesis investigates how galaxies form and what diversifies the evolutionary histories of galaxies.
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The holographic glass bead game: from superconductivity to time machines
Promotores: Prof.dr. J. Zaanen & Prof.dr. K.E. Schalm
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Unlocking Nature’s Pharmacy from Bogland Species
Development of Natural Resource for New Medicines
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Photosynthetic light reactions at the gold interface
Promotor: Prof.dr. T.J. Aartsma, Co-promotor: R.N. Frese
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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Progressive Indexes
Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…