2,010 search results for “heart and vascular disease” in the Public website
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Reconstruction and Computational Modelling for Inherited Metabolic Diseases
Accelerating the diagnosis and personalising the management of inherited metabolic diseases.
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Systems diagnosis in chronic disease: prediction and evaluation
Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen
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Human epidermal lipid biosynthesis in health and disease
How are the epidermal lipid pathways involved in health and disease.
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Patient Remote Monitoring in Chronic Inflammatory Skin Diseases
Chronic inflammatory skin diseases such as psoriasis and atopic dermatitis affect both the physical and psychological well-being of millions of patients, leading to persistent symptoms like itchiness and sleeplessness. These conditions often result in decreased productivity and quality of life overall,…
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Single cell mechanics for disease biology and pharmacology
In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.
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Cardiovascular and Metabolic Therapeutics
This research group, headed by Miranda van Eck, focusses on understanding the molecular mechanisms underlying cardiovascular and metabolic diseases. Cardiovascular disease constitutes a major health issue worldwide. Although significant knowledge has been obtained on the development of atherosclerotic…
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SysMedPD: Systems Medicine of Mitochondrial Parkinson's Disease
The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…
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Studies on the Pathogenesis of Chronic Kidney Disease
In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…
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The right diagnosis and faster for women with heart problems
It often takes longer for women with heart problems to get the right diagnosis. In her Annie Romein-Verschoor Lecture, Professor Hester den Ruijter will talk about how hormones influence the heart and the importance of medical research that focuses specifically on women.
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smartphone behaviour to understand healthy ageing and neurological disease
Leiden University researchers and their collaborators report the development of new research frameworks that use day-to-day smartphone behavior gathered from a large sample of healthy people to help understand aging, and how aging alters with epilepsy and stroke. These reports occupy two back-to-back…
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data-based dynamic modeling to cell-cell signaling and infectious disease spreading
The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…
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Fundamental research: Underlying mechanisms of disease and health
To make the right clinical decisions or develop effective diagnostic tests and treatments, it is important to understand the underlying mechanisms of a condition or behavior.
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Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
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PROPER: ‘Near-patient’ prostate cancer models for the assessment of disease prognosis and therapy
How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?
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Lifestyle and nutrition to combat diseases (of affluence)
We know this, but we don’t act on it: eat healthily, move more, address our stress levels and sleep well. Internist and Professor of Diabetology Hanno Pijl is fascinated by the effect that a healthy lifestyle can have on health. He researches how this lifestyle is achievable and satisfying, for patients…
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Metabolomics to predict progression in chronic kidney disease
PhD defence
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer
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Postdoc fellowship from the Dr. E. Dekker stipendium awarded by the Dutch Heart Foundation.
Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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Miranda van Eck hoogleraar Cardio Vascular & Metabolomic Therapeutics
Miranda van Eck is benoemd tot hoogleraar Cardio Vascular & Metabolomic Therapeutics bij het Leiden Academic Center for Drug Research (LACDR) van de faculteit der Wiskunde en Natuurwetenschappen. De benoeming ging per per 1 februari 2014 in.
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Research in Africa reduces health spending and prevents diseases of affluence
Health workers have always sought ways to fight disease in vulnerable groups in the population. It is now clear that such research also benefits more prosperous countries. African worm infections and innovative thermometers have shown Leiden researchers how to fight diseases of affluence and keep health…
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The Layered Heart: Essays on Persian Poetry, A Celebration in Honor of Dick Davis
The Layered Heart : Essays on Persian Poetry is published in celebration of the poet and scholar Dick Davis, dubbed “our pre-eminent translator from Persian” by The Washington Post.
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PKPD and disease modelling in therapy development for amyotrophic lateral sclerosis (ALS)
We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.
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Stratum corneum ceramide profiling in immune-mediated inflammatory skin diseases
This project is part of the Next Generation ImmunoDermatology (NGID) consortium, which focuses on the comprehensive phenotyping of six different immune-mediated inflammatory skin conditions. A common factor contributing to these diseases is a dysfunctional skin barrier. The skin barrier function is…
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brain connectivity: pharmacological modulation, aging and Alzheimer's disease
Psychologist Bernadet Klaassens initiated a large fMRI study on the effect of drugs on brain networks in aging and Alzheimer's disease. It generated a unique data set and insight into a new method to develop drugs for patients with Alzheimer's.
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Ahmed Mahfouz: 'The mystery of brain diseases, unravelled cell by cell'
Which brain cell does what, when Parkinson's disease arises? It won't be long before this jigsaw is solved piece by piece. Ahmed Mahfouz, computational biologist, combines bio-knowledge from Leiden with algorithms from Delft and is getting closer to finding the key.
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Modeling interactions to unravel biomarkers for disease progression and treatment response
The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets
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Prediction of human (CNS) target site concentrations in health and disease
Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…
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Bram Slütter
Science
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Stressed brain, stressed heart?
Ilze Bot and Johan Kuiper have published in The Lancet: Study unveils how stress may increase risk of heart disease and stroke. Aso: The National Dutch newspaper 'NRC' has mentioned them in a column
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stable-isotope labeling: exploring neuronal metabolism related to Parkinson’s disease
The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.
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Unraveling the broad NOTCH3-associated small vessel disease spectrum: from CADASIL to non-penetrance
PhD defence
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pharmacology of antimicrobials, towards optimized treatment of infectious diseases in hospitalized patients
PhD defence
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Insight into the Pathophysiology of Cardiometabolic Diseases using multiple Omics Approaches
PhD defence
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Cardiac Computed Tomography Angiography and Characterization of Cardiac Disease
PhD defence
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Unravelling the Developmental Origins of Disease: The Power of Mesenchymal Stromal Cells and Monochorionic Twins
PhD defence
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Frits Rosendaal
Faculteit Geneeskunde
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Medicine/Leiden University Medical Center
We are very happy to welcome you to spend a semester or year studying or doing an internship with us at the Leiden University Medical Center. Here you will find information on your course timetables and registration.
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Cannabinoid receptor 2 as a ‘drugable’ target: kinetic profile of novel receptor ligands
Supervisor: Andrea Martella
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biology of common and grey seals along the Dutch coast : stranding, disease, rehabilitation and conservation
Promotores: H.A. Udo De Haes, P.M. Brakefield
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Combatting infectious diseases; nanotechnology as a platform for rational vaccine design
Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.
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Macrophage activation and cholesterol accumulation in atherosclerosis development
Promotores: Prof. Dr. Th.J.C. van Berkel, Prof. Dr. M. van Eck
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Antonius Johannes Rabelink
Faculteit Geneeskunde
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Almost 19 million euros for development and study of organs-on-chips
It sounds futuristic, but it is possible: the creation of miniature organs of patients in order to study them and see how diseases develop and can be treated. This is what researchers from the LUMC, Twente University (UT), UMCG, TU Delft and the Hubrecht Institute hope to achieve in the next ten years…
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Maximal Systolic Acceleration in atherosclerotic vascular disease
PhD defence
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Dorien Peters
Faculteit Geneeskunde
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Paulus Quax
Faculteit Geneeskunde
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Bart Verkuil
Faculteit der Sociale Wetenschappen
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Preventing or curing diseases with X-omics
In April, the X-omics initiative was granted 17 million euros from the Dutch Organization for Scientific Research. The subsidy is part of the National Roadmap for large-scale scientific infrastructure, intended to build or renew large-scale research facilities. What new insights will this investment…
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Boudewijn Lelieveldt: 'AI can help, but not replace, doctors and other healthcare providers'
‘I would never want to be treated by a computer,’ says Boudewijn Lelieveldt, Head of Radiology at the Laboratory for Clinical and Experimental Image Processing and Medical Delta professor in the Bioinformatics group at Delft University of Technology. No matter how intelligent a system, we have to continue…