631 search results for “stem cell differentiation” in the Staff website
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Micha Drukker -
Bas ter Braak -
Willem Fibbe -
Differential case-marking in Ecuadorian Siona
PhD defence
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A tail with a twist: how the tokay gecko grows a completely new body part
When the tokay gecko loses its tail, a new one grows from resident stem cells at the stump. Each tissue type - muscle, bone, blood vessels and skin - develops from specific stem cells. This discovery by Luthfi Nurhidayat holds potential implications for advancing regenerative medicine in humans. Nurhidayat…
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300 million euros for new international stem cell consortium
The Leiden University Medical Center (LUMC), the Danstem Institute from the University of Copenhagen and the Murdoch Children’s Research Institute in Melbourne have received 300m euros from the Novo Nordisk foundation. The aim of this new international consortium is to bring stem-cell based therapies…
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Christine Mummery -
LUMC will administer first Dutch stem cell gene therapy to patients
Researchers and clinicians at Leiden University Medical Centre (LUMC) are about to begin a milestone clinical study. It will be the first time a stem cell gene therapy developed in the Netherlands is used in a clinic. The therapy will be used to treat children with SCID, a rare disorder where children…
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LUMC receives tens of millions for research into new stem cell-based treatments
Leiden University Medical Center (LUMC), as a partner in the reNEW consortium, is once again receiving tens of millions of euros for research into new treatments based on stem cells. The collaboration will receive a total of €150 million to develop new therapies in regenerative medicine.
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First patient in the Netherlands successfully treated with stem cell gene therapy
Researchers from the Leiden University Medical Center (LUMC) have successfully used stem cell gene therapy to treat a baby with the severe congenital immune disorder SCID. An important milestone: it is the first time stem cell gene therapy of Dutch origin has been administered to a patient, and also…
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The career choices of cells
How does an embryonic stem cell decide if it becomes a heart cell or a kidney cell? That’s the question computational biologist Maria Mircea studied for her PhD research. She looked at the inside of individual cells to analyse how they change. This is what she discovered.
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Joey Zuijdervelt -
Transcriptional regulation of effector-triggered immunity (ETI): from tissue to cells
PhD defence
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Towards microbial platforms for lignin valorization: Pseudomonas putida cell factories and Bacillus synthetic communities
PhD defence
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Serkan Aslan -
Curing diseases with lab-grown organs
Organs and tissues grown in the lab may in the future be able to cure people with organ failures. Micha Drukker, professor of Stem Cells, Developmental Biology and Technology for Innovative Drug Research, is convinced that the use of stem cells will make this possible. He will deliver his inaugural…
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Dennis Claessen -
Medical milestone at LUMC: first Dutch patient receives CAR T-cell therapy for autoimmune disease
The LUMC has become the first institution in the Netherlands to treat a patient with an autoimmune disease using CAR T-cell therapy.
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Frank Schaftenaar -
Interview Micha Drukker
Micha Drukker
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Young, sleeping memory cells are crucial in fighting a reinfection
Researchers from the Netherlands Cancer Institute, the Leiden University Medical Center (LUMC) and Oncode have created a tracking system that can reveal how often cells have divided. This allowed them to find a yet undiscovered population of immune cells: young memory cells that behave like stem cells.…
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Organising STEM effectively, both within and beyond the faculty
Tuesday 27 January - A crisp winter morning and a busy Tuesday. Board matters, research safety, leadership and faculty profiling alternate throughout the day, with a focus on collaboration both inside and outside the faculty. A full day that ends with a game of darts.
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Erik Danen -
Noortje Dannenberg -
Tessa Vergroesen -
Ewa Snaar-Jagalska -
How cells talk by pulling on a fibre network
Mechanics play a larger role in blood vessel formation, and other developmental biology, than previously thought. Cells appear to respond to mechanical signals, such as pressure. Through the extracellular matrix, a network of fibrous proteins, cells can supposedly exchange those mechanical signals over…
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Bacteria without cell wall gobble up DNA from environment
A bacterium hiding from the immune system and picking up bits of DNA from its environment. The result: gaining new traits, such as better protection against antibiotics. Fortunately, we have not found such a damning scenario yet. However, PhD student Renée Kapteijn did find the first clues, which…
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Greater understanding of specialised cell could prevent strokes
Ilze Bot wants to reduce the prevalence of cardiovascular diseases. Her research focuses on mast cells, which protect us from infections but can also make us ill.
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How cells work together: the mathematics behind biological shapes
How do biological cells join forces to form a structure? In her PhD research, Daphne Nesenberend uses mathematics to show how forces and cooperation between cells create structure – and how simulations and experiments can reinforce each other.
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Max Fernkorn -
Eliane Züger -
Jingchao Wu -
Andreea Iosif
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Yubin Guo -
Ruben de Vries -
Nina Schulten -
Ferdinand Teichert -
Yuting Wang -
Benjamin Tak -
Rafaella Buzatu -
Anita Liao -
forming embryo to cancer metastasis: the significance of collective cell movement
Luca Giomi has the first results of his ERC consolidator grant. He discovered that epithelial cells move collectively but in different ways, depending on the scale you look at. It is hexatic at small scales, and becomes nematic at larger scales: it is a multiscale order. This collective movement of…
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Marjolein Crooijmans -
Templeton Grant Drukker News
In a project funded by the John Templeton Foundation to the group of Micha Drukker, scientists will produce stem cells from short and long living understudied species to model cellular and organismal lifespan.
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Arthur Ram -
Julia Cramer -
Inexhaustible source of human heart muscle cells allows strong reduction of animal testing
Researchers at the Leiden University Medical Centre (LUMC) have managed to culture human heart muscle cells on a massive scale. This is an exceptional achievement because it is very difficult to replicate heart muscle cells outside the body. Using a special technique, the researchers have now created…
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Stiffness and viscosity of cells differ in cancer and other diseases
During illness, the stiffness or viscosity of cells can change. Tom Evers demonstrated this by measuring such properties of human immune cells for the first time. ‘The stiffness of certain cells could be a way to make a diagnosis,’ Evers said. He defended his thesis on March 26th.
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Grants for research on immune cells, vegan cheese and PFAS detection
Researchers at the Faculty of Science work at the frontiers of knowledge every day, tackling today’s major societal challenges. Their work is recognised through grants, prizes and other awards. We highlight some of these achievements below.