2,045 search results for “health” in the Public website
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Stacked Domain Learning for multi-domain data: a new ensemble method
The aim of this project is to develop accurate but interpretable ensemble learning methods for high-dimensional multi-domain data.
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Service desk Campus The Hague
Wijnhaven, Turfmarkt 99, 2511 DP, The Hague
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Clinical applications of (pharmaco)metabolomics
The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Understanding the uptake and internal distribution of metallic nanoparticles in Danio rerio larvae
The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.
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A bibliometric review of COVID-19 research in the crisis and disaster literature
In the wake of the COVID-19 pandemic, the pressing question is how this global health emergency impacted the research agendas of the field of crisis and disaster science. This article reviewed contributions in ten important crisis and disaster journals in the two and a half years following the COVID-19…
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Inaugural lecture: Data science and Ebola
Today, everybody and everything produces data. People produce large amounts of data in social networks and in commercial transactions. Medical, corporate, and government databases continue to grow. Sensors continue to get cheaper and are increasingly connected, creating an Internet of Things, and generating…
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Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
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Institutional trust
Trust in public institutions in the Tata Steel case and beyond
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A large-scale crop protection bioassay data set
ChEMBL is a large-scale drug discovery database containing bioactivity information primarily extracted from scientific literature.
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Bioengineering and biophysics of viral hemorrhagic fever
Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…
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PLATO
Platform Opleiding, Onderwijs en Organisatie Ltd (PLATO). PLATO is committed to learning, learning in schools, learning in work environments, learning in life and life.
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Collaboration
Leiden University wants its research and teaching to have a positive impact on society. In an effort to achieve this, many of our researchers collaborate with academic and community partners, non-governmental organisations and the business sector.
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CAM-PaC
The overall aim of CAM-PaC is to contribute to solving the socioeconomic and health challenges of PDAC by an integrative and systematic functional analysis of pancreatic cancer candidate genes. CAM-PaC will develop novel cellular and animal models, as well as novel strategies to analyse and integrate…
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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About
The Centre for Indigenous America Studies (CIAS) at Leiden University is designed to coordinate and promote the teaching and research of Indigenous languages, literatures, cultures and cultural heritage. Our aim is to contribute to an increased acknowledgement, recognition and understanding of Indigenous…
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HJD Diplomacy Reading Lists
Since 2006, HJD has made an important contribution to shaping diplomatic studies as an international academic field. Our new HJD Diplomacy Reading List presents a diverse collection of analyses categorized into forty-five topics published in HJD over the years. We hope these lists prove a valuable resource…
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D-lightful Sunshine Disrupted
This study stresses the importance of investigating vitamin D deficiency in every community to better understand the deteriorating effect that sociocultural practices may have had on health.
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NO-ESKAPE New Strategies for Overcoming the ESKAPE Pathogens
Natural product inspired antibiotics to address resistance
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Servicedesk W&N
Gorlaeus Building, Einsteinweg 55, 2333 CC, Leiden
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Domestic Homicide
Behavioral Sciences Mental Health Psychological Disorders - Adult Aggression in Adults Psychological Science Social Psychology Criminology & Delinquency Social Sciences Criminology and Criminal Justice Crime and Crime Prevention Criminal Behaviour and Forensic Psychology Violent Crime Law Criminology…
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Nature and human interactions
It is well-known that humans have significantly transformed ecosystems since their adoption of agriculture. However, in a deeper past, prehistoric hunter-gatherers may already have altered and modified their niche in ways that had major impacts on ecosystems.
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Two cities
Leiden University is established in two cities: Leiden and The Hague.
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Civic Duty
This study offers a new view on public services in the early modern Low Countries and answers the following questions: who provided public facilities in urban communities and in which ways did public amenities change in the period between 1500 and 1800?
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Service desk Rapenburg
Oude UB, Rapenburg 70, 2311 EZ, Leiden
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Bolivia at the Crossroads: Politics, Economy, and Environment in a Time of Crisis
As Bolivia reels from the collapse of the government in November 2019, a wave of social protests, and now the impact of Covid-19, this book asks: where next for Bolivia?
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The impact of climate variability on the ecology of a lion (Panthera leo Linnaeus 1758) population and lion livestock conflicts in the Amboseli
Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon
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Screening of animal venoms for antimicrobial compounds
Can animal venoms yield novel antimicrobial peptides?
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Evaluation of the Dutch Youth Act
This research evaluates the Youth Act. It will provide an overview of how the transition takes place, whether the transformation process develops in the right direction and whether the legal safeguards are functioning properly.
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Tiempo y Comunidad: Herencias e Interacciones Socioculturales en Mesoamérica y Occidente
ASLU 29 Maarten E.R.G.N. Jansen, Valentina Raffa (2015)
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Development of an effective, safe, and painless intradermal tuberculosis vaccine based on microneedles loaded with antigen-containing nanoparticles
Tuberculosis (TB) is a major global health problem caused by the bacterium Mycobacterium tuberculosis (Mtb). In 2015, there were estimated to be 10.4 million new cases and 1.8 million deaths ascribed to TB, making it one of the top 10 causes of death worldwide. Unfortunately, the only current registered…
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Developmental effects of polystyrene nanoparticles in the chicken embryo
There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.
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Service desk Pieter de la Court
Pieter de la Court, Wassenaarseweg 52, 2333 AK, Leiden
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Chemical biology of glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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Effectiveness of audience segmentation in instructional risk communication: A systematic literature review
This article provides a list of the concepts and key elements that should be considered when creating effective communication messages.
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Forces and symmetries in cells and tissues
The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.
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Study of utilization of combined hormonal contraceptives in Europe
Combined hormonal contraceptives (CHC) are associated with an increased risk of venous thromboembolism (VTE). In 2013, a review was published by the European Medicines Agency (EMA). In this review, the authors concluded that the risk of VTE varies by the type of progesterone in the CHC. Subsequently,…
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Optimizing antifungal treatment through pharmacometrics: dosing considerations to enhance outcome
Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.
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Service desk KOG
Kamerlingh Onnes Building, Steenschuur 25, 2311 ES, Leiden
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Development & Disease in Animal Sciences
Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.
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Research
The University wants its teaching and research to have the maximum academic, cultural, social and economic impact.
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Lipid signaling and inflammation: metabolomics for better diagnosis and treatment strategy
Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…
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Mining Sensor Data from Complex Systems
Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe
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Strategic Partnerships/ Cooperation Partnerships
Erasmus+ Strategic Partnerships (Key Action 2) are transnational projects designed to develop and share innovative practices and promote cooperation, peer learning, and exchanges of experiences in the fields of education, training, and youth. There are two kinds of Strategic Partnership; those supporting…
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What is Citizen Science?
In citizen science projects, citizens and scientists work together to develop new scientific knowledge.
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Jimpitan in Wonosobo, Central Java: an indigenous institution in the context of sustainable socio-economic development in Indonesia
In times of hardships or crisis, local people know how to deal with it using their resourcefulness. Although efforts are sometimes made by the government to help them, they are fully aware that community support is at least equally important.
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Efficacy of Self-management training in adolescents and adults with Klinefelter syndrome (XXY)
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Host-Microbe Interactions
Host-Microbe Interactions is one of the four research themes of the Institute of Biology Leiden.