Persistent somatic symptoms are long term symptoms that lack a clear medical explanation. These symptoms have a high prevalence where most people know someone who experiences such symptoms or they experience such symptoms themselves. Symptoms can vary greatly in and between people. While one person…

To investigate the effectiveness of an online self-help programme for people with HIV and depressive symptoms.

Pharmacometrist Bas Goulooze has won the prestigious Lewis Sheiner Student Session award. He received the prize of 300 euros at the annual conference of the Population Approach Group Europe (PAGE) in Stockholm, where he presented his research for 800 people.

A new therapy for the serious Graft-versus-Host disease

What is the effectiveness of (booklet or online) self-help programmes for people with somatic stressors and depressive symptoms? What works best for whom? How to improve motivation and adherence?

Somatic symptoms, such as pain, itch, and fatigue have been shown to have a bidirectional relationship with mental symptoms. Although acute somatic symptoms serve some adaptive properties, chronic symptoms can instead lead to interference in daily activities and lower quality of life.

The STAP study examines the cost-effectiveness of Written Exposure Therapy (WET) for post-traumatic stress disorder (PTSD) symptoms in primary care settings.

We found that, next to the effectiveness of the intervention, it’s also very likely that the intervention is cost-effective compared to attention only.

CERQ is a questionnaire measuring cognitive coping strategies developed by Dr. Nadia Garnefski and Dr. Vivian Kraaij.

People already diagnosed with a mental disorder before the COVID-19 pandemic did not show a disproportionate increase in symptoms afterwards. This is one result from the first systematic review of longitudinal studies following their study population from before to during the first eighteen months of…

Our mission is to improve the description, prediction, understanding and the prevention and treatment of mood disorders, including unipolar and bipolar depression, as well as suicidal thoughts, feelings, and behaviors. To tackle this ambitious mission, we focus on several research streams.

Can positive peer feedback break the cycle of negative self-relevant cognitive processes and reduce self-reported anxiety in early adolescents?

Our vision of stress is starting to change fundamentally. We can suffer stress without even being aware of it, while sleeping as wall as during the day. Professor of Psychology Jos Brosschot will discuss this phenomenon in his inaugural lecture on 2 December.

This longitudinal study is focused on neurodevelopmental problems in young children with XXY, XXX and XYY, aged 1 to 6 years.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Elk jaar organiseert het LIBC in samenwerking met de gemeente Leiden een Publieksdag over hersenonderzoek.

The key question addressed in this family study is whether the psychophysiological and neurocognitive abnormalities often reported in SAD patients are heritable and can thus be found in family members of SAD patients as well. Determination of heritability of these deficiencies is essential for endophenotyping.…

Optimization, mechanisms of action and predictors of the outcome of light therapy in depression: A multicenter randomized trial

Members of our research team give different types of presentations and lectures.

The ability to collect and interpret huge quantities of data has become indispensable to society and academia. Leiden University is a knowledge and expertise centre for data science that places the emphasis on interdisciplinary collaboration and innovation.

ADHD & ME aims to explore how enhancing self-esteem can break the relation between ADHD symptoms and comorbid disorders, such as anxiety and depression. In this study we assess the effectiveness of a Cognitive Behavioural Therapy (CBT) program called Competitive Memory Training (COMET) for improving…

Exploring the synergy of light therapy and exposure psychotherapy to enhance PTSD treatment outcomes.

In a longitudinal study, Eichengreen and colleagues explored how the certain aspects of emotional intelligence impact the development of adolescents’ mental health, thus identifying potential warning signs and targets for intervention programs. Despite a higher risk for mental health issues and lesser…

Disclaimer: Manuscripts related to the Resilience Center are for academic purposes only and are not intended for mass distribution or copying. Please refer to applicable laws for fair use, including copyright holders' restrictions on publications.

We investigate the molecular basis underlying health and disease and provide answers to existing and emerging health problems. Within this theme, we study diseases ranging from rare genetic disorders to cancer and infectious diseases. We make use of a wide variety of model systems and pursue diverse…

Programs that aim to reduce symptoms of social anxiety in children generally include multiple components, such as exposure and cognitive restructuring. It is unknown if separate components yield positive intervention effects in children or whether a combination of components is required.

Our mission is to recognise and treat stress and anxiety in children as early as possible, by connecting scientific research, clinical practice and education.

What role do parent-child interactions play in the development, maintenance and treatment of depression in young people?

The overarching aim of this theme is to increase our understanding of the mechanisms underlying altered cognitive, affective, and social behavior in relation to mental health problems.

Josien de Klerk and Tennessee Miller examined the interplay between students’ illness and recovery experiences and academic work culture in this context.

Promotor: Prof.dr. J. den Hertog

To make the right clinical decisions or develop effective diagnostic tests and treatments, it is important to understand the underlying mechanisms of a condition or behavior.

The ‘Leer te Durven!’ program (Learn to Dare) is a preventive training program for children with mild anxiety symptoms (Simon & Bögels, 2014). The program has been developed for children between the ages of 8 and 12 who feel or behave anxiously, avoid situations, are afraid of doing things wrong, appear…

What are the social and neural mechanisms that contribute to fluctuations in self-esteem in healthy adolescents and adolescents with depression?

The LHSC booster grants awarded are described below. The summaries below are aimed at the general public. For further detail, please contact the researchers in question.

Positive friendships are characterised by understanding mutual wishes and intentions, respect for each other’s boundaries and pro-social behaviour. Qualities that might be more challenging for autistic adolescents.

Learning about circadian rhythms can help students to improve their sleep and overall well-being

The effects of many treatments are determined, to a significant degree, by factors other than the medicine or treatment itself. For example, placebo effects can be equal to the effect size of for example antidepressants or painkillers. Contributing factors are the trust placed in the doctor, the expectation…

The substance galanthamine from flower bulbs can fight symptoms of Alzheimer's disease. Nadeem Akram investigated how daffodils can optimally produce this natural remedy. PhD defence on 24 June.

Primary Objective: The primary aim of the proposed RCT is to evaluate whether LF-TLP in blended form as an indicated prevention for anxiety complaints is more (cost-) effective than TAU according to the NHG guideline Anxiety. We hypothesize that in comparison to TAU, LF-TLP will result in a significantly…

New funding allows IBL-researcher Herman Spaink to purchase a measurement device for more studies on human diseases such as cancer and tuberculosis using zebrafish as the model system.

Leiden University Medical Center (LUMC) has just launched its COVID Radar app. Users of the app are asked to regularly complete a short questionnaire about their health, regardless of whether they are ill or not. This will give the researchers a good idea of the current spread of coronavirus in the…

(04-11-2020) The visitor center of the Old Observatory is closed until November 15th 2020 in line with the national corona measures in the Netherlands. When we reopen, please pay attention to our corona regulations:

Serge Rombouts is a physicist whose PhD thesis was about functional MRI (fMRI). This visualises activity in regions of the brain. The appealing images of glowing brain regions that emerge from the computer are the result of calculations. According to Rombouts, this isn’t proper artificial intelligence.…

The Institute of Psychology is committed to play a prominent role in teaching and research at the national and international level.

The research connected to this topic is related to Work and health.

This book aims to understand cultural transitions and negotiations between art and politics from 1989 to 2020 through analysis of a series of Cuban novels.

PhD defence

The major aim is to determine the psychophysiological responses to stress and stress-management interventions and to examine the role of stress and stress-related psychophysiological mechanisms (e.g., cognitions, behaviors, and physiological stress responses) in both healthy and medical populations.

Predictors of work functioning in persons with multiple sclerosis