1,628 search results for “this weeks discoveries” in the Public website
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Chemical Probe Facility
The Chemical Probe Facility is part of the Leiden Early Drug Discovery & Development (LED3) center. Activity-based protein profiling (ABPP) is one of the pillars of chemical biology. ABPP determines the activity of entire protein families in living cells and tissues under physiological conditions, such…
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Bio-organic Synthesis
The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…
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The Dakhleh Oasis Project
Update : March 2020 A.J. Mills
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Computational Network Science Lab
The Leiden Computational Network Science Lab (CNS Lab) researches methods for knowledge discovery from real-world network data.
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Formation of synthetic fuel: new insights!
Navarro Paredes
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Microvasculature in Microfluidics: matching complexity with compatibility
In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…
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Projects
The Young Academy Leiden and its workgroups have launched different initiatives in the interest of early-career scholars. Read all about the different projects of the Young Academy Leiden here.
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Applied String Theory: Explaining Quantum Matter with Black Holes
Schalm
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Master Students MPS Hold up Mirrors in front of Managers during Shadow Week
How do you bring education and practice closer together? In the revised Master MPS (Management of the Public Sector) it is done, for example, through the new profile course Leadership & Behaviour inside and between organisations. The Leiden Leadership Centre (LLC) is involved in organising the course.…
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Last Week’s Hype: On the Blackstar album and death of David Bowie
Can David Bowie’s death be seen as a carefully staged hype, just one last version of the musician’s ever-surprising public persona? Cultural Studies researchers Gerlov van Engelenhoven and Bram Ieven look into it.
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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Island Networks
The focus of this programme is the inter-community social relationships and transformations of island networks in the Lesser Antilles across the historical divide.
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Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.
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Grants & Awards
Grants awarded to molecular physiology research
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Small-molecule inhibitors of bacterial metallo-β-lactamases
The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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LED3 Lectures
The LED3 hub, consisting of researchers from the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden (IBL) and the Leiden Academic Centre for Drug Research (LACDR), is very excited to organize the “LED3 Lectures”. This lecture series brings world-leading researchers in the field of…
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Master's application and admission
Find out how to apply for Drug Discovery and Safety at Leiden University by following our step-by-step guide.
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Key publications
Key publications of the Cancer Drug Target Discovery group
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A Successful Week in Washington D.C. for Moritz Jesse - Lectures, book presentation and Moot Court
One Lecture about Immigrant Integration in the EU and its Member State at the Institute of European Studies at George Washington University, one class in a course on Immigration and Integration at Georgetown University, and a lot of judging in the international rounds of the Phillip C. Jessup International…
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Shadowing council boss for a week: 'I saw him mostly putting out a lot of fires'
After a week of shadowing for her master's degree in Public Sector Management, it has become very clear to student Loes what a manager's day looks like. 'He was putting out fires all day.'
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Harnessing zebrafish xenograft models for ocular melanoma treatment discovery
PhD defence
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LED3 Chemical Biology Talk: Cyclic Peptides in Target Discovery
Lecture
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Antibiotic Discovery: From mechanistic studies to target ID
PhD defence
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Discovery of BUB1 kinase inhibitors for the treatment of cancer
PhD defence
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Madouc Bergers made her own enzyme inhibitors for her bachelor’s thesis
For her bachelor’s thesis, Molecular Science and Technology student Madouc Bergers synthesized her own molecule that can inhibit the breakdown of sugars. Although most students do not even manage to make one building block, Madouc made three. Partly because of this, she has been nominated for the Science…
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Glyco(proteo)mic Workflows for Cancer Biomarker Discovery
PhD defence
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From data to discoveries: machine learning and optimization in space
Lecture
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already going to see this effect of the coalition agreement in the coming weeks'
Few details, relatively few words. The coalition agreement presented is one of the shortest in the past 20 years, Arco Timmermans knows. Consequently, the outlines were not negotiated for very long, which has its advantages and disadvantages. 'Over the next few weeks, we are mainly going to see the…
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More effective blocking of CCR2 receptor
The discovery of new medicines is a tedious and lengthy process. On average, over 10,000 molecules need to be studied for one to become a drug and reach the patient. Part of that process are the very costly clinical trials in humans, and candidate drugs often fail due to side effects or lack of efficacy.…
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ZF-CANCER - Developing high-throughput bioassays for human cancers in zebrafish
How can zebrafish research help to understand and fight human cancer?
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AiChemist project
The AiChemist project (https://aichemist.eu) coordinated by Helmholtz Munich is an Innovative Doctoral Training Network funded through the Marie Skłodowska-Curie Actions (MSCA-DN) within the EU Horizon Research Framework, to the sum of €3 million. It brings together leading experts in AI, chemoinformatics…
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The scientists behind LED3
LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.
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Saqqara Project 2019
This week the good news broke as the Egyptian authorities have given their permission to continue the excavations in Saqqara in 2019!
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Exploring the mechanisms of metastatic onset for novel treatment strategies
This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.
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Towards the development of synthetic vaccines against tuberculosis
The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.
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Education
Studying linguistics at the Leiden University Centre of Linguistics (LUCL) is a challenging but rewarding experience. There are few places in the world where such a broad range of languages are studied from so many different perspectives.
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Top 450
What is the best thing ever about Leiden University?
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Bioactive Molecules
Bioactive Molecules is one of the four research themes of the Institute of Biology Leiden.
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Master student Maddalena Centanni awarded with Arenberg-Coimbra Group Prize
Former masterstudent Bio-Pharmaceutical Sciences Maddalena Centanni will be awarded the 2020 Arenberg Coimbra Prize for Erasmus Students. Centanni spent her six month Erasmus exchange at Uppsala Universiy in Sweden where she looked for ways to improve anti-cancer drug dosing.
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Ilyasse’s photo went viral: ‘It was quite a bizarre week’
It was meant as a joke for friends and family. A quick snap of him with his bags packed while watching the exit polls of the Dutch general elections. But the photo of our colleague Ilyasse El Boujadayni soon found its way around the entire country and before he knew it, he was being invited by national…
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Chinese exchange professors meet Faculty of Science
Two professors from China joining the research and education in Leiden, two Leiden professors going to China to share their knowledge and experiences in return. This is the exchange professorship between the Faculty of Science and Xi'an Jiaotong University (XJTU). This week, all four professors got…
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How Oncode-PACT is bringing new cancer medicines closer with 325 million in Growth Fund money
How can you ensure that more experimental drugs reach the finish line? At the moment, only one in twenty cancer drugs that are tested on humans makes it to the market. This is an enormous loss for patients and society. With a grant from the National Growth Fund, Oncode-PACT aims to efficiently select…
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Discovering and developing drugs
Improving healthcare with our scientific discoveries: that is the goal of pharmaceutical research at Leiden University. And there’s a lot involved in that. Our research starts with the discovery of the effect achieved by a particular substance, and sometimes continues all the way through to the development…
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Ukraine
This is an Erasmus+ International Credit Mobility project of the Faculty of Science with the Taras Shevchenko National University of Kyiv.
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Hit and Lead Optimization
The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'
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Of home-loving men and intinerant marriageable women
Some 5000 years ago the people of the corded ware culture exchanged ideas about death on a continental scale. There were strong gender differences in these ideas: men were buried in an international style, and women in a local style. This discovery was made by archaeologist Quentin Bourgeois.
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PROPER: ‘Near-patient’ prostate cancer models for the assessment of disease prognosis and therapy
How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?
- Time Seminar: Applications of Artificial Intelligence in Early Drug Discovery