2,522 search results for “computer aided drug design” in the Public website
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NMR studies of protein-small molecule and protein-peptide interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Mark Roelofsen
Faculty Governance and Global Affairs
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Simon Portegies Zwart
Science
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Laura Heitman
Science
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International astronomers come to the aid of secluded Cuban scientists
An international collaboration of astronomers is organising a special online lecture series for physicists and astronomers in Cuba. The reason for this is the tightening of measures against this country, as a result of which researchers can hardly get any information from outside the island. ‘Everyone…
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De Witte et al publish in Nature Drug Discovery Reviews
Nature Reviews Drug Discovery volume 18, pages 82–84 (2019). The implications of target saturation for the use of drug–target residence time Wilbert de Witte, Meindert Danhof, Piet van der Graaf, and Elizabeth de Lange
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Van der Leun and Rodrigues on the criminalisation of migrant aid
Aid workers being summoned to appear before a court in Greece and more stringent rules for rescue boats in Italy. Is providing aid to asylum seekers being criminalised? There's no doubt about it, according to Joanne van der Leun and Peter Rodrigues.
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The chemistry behind cancer drugs: searching for fewer side effects
PhD candidate Dennis Wander searches for the best of both worlds. That is to say: a cancer drug that is effective and also has minimal side effects. To this end, he makes new molecules inspired by two existing medicines. And not without result: ‘We have created a new variant that is very promising.’…
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Drug discovery 3.0: more effective and humane
Discovering effective new drugs is a long, expensive and uncertain process. Laura Heitman wants to improve this by finding out more about how drugs bind to proteins that play a role in disease. She calls it ‘drug discovery 3.0’. Inaugural lecture on 9 December.
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Impurities in sugar excipients could cause drugs to fail
Sugar excipients, needed to stabilize medicines, can be unsafe for patients due to an impurity discovered recently by Daniel Weinbuch. ‘The biopharmaceutical industry should now consider new excipient quality criteria for safer drug development,’ he says. PhD defence on 13 December.
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GTGC lunch seminar: Santino Regilme on Global Drug Wars
On the 6th of March 2023, Santino Regilme presented his work-in-progress titled 'Global Drug Wars: Contested Normative Orders of Peace, Security, and Human Rights'. If the battle against illegal drugs is construed as a war, how is victory in such a war defined and constructed? If the oppositional…
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Discovery of antibiotics and their targets in multidrug-resistant bacteria
Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.
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Gut-on-chip good predictor of drug side-effects
Research conducted at Leiden has established that guts-on-chips respond in the same way to aspirin as real human organs do. This is a sign that these model organs are good predictors of the effect of medical drugs on the human body. Publication in Nature Communications on 15 August.
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Mexican drugs world pans out into hybrid war
Drugs-related violence in Mexico is similar in terms of dynamics and strategy to the IS hybrid war in the West. This is the claim made by Teun Voeten. PhD defence 20 September.
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Sensing drug responses of single cells using optical tweezers
Light can be used to apply forces on single cells. Focused lasers have been used by physicists to tweeze particles and to manipulate them. These so called “optical tweezers” can be used as mechanical phenotyping tools for characterising the mechanics of materials and living objects.
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Mathematical model predicts drug concentration in the brain
Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…
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Drug development: how can we make it more efficient?
It takes years to develop new medicines, from the test tube to trials in humans. During the process it often happens that a drug that seems promising in the initial stage has to be dropped in a later phase. This costs time and money. Leiden University and the LUMC are working closely together to make…
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Making everything we know computer-readable
Data and information should be stored in a way that computers can understand, says Barend Mons, professor of Biosemantics at the Leiden University Medical Center and Chair of the High Level Expert Group for the European Open Science Cloud. We speak with him about FAIR data, knowlets and nanopublicat…
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Arco Timmermans Discusses Second Economic Aid Package on Dutch BNR Radio
Following the announcement of the second economic aid package by Dutch Ministers Eric Wiebes, Wopke Hoekstra and Wouter Koolmees, Arco Timmermans discussed the content of the government's second economic package on the Dutch radio programme BNR Lobbypanel.
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Jeanette Satink visits the Beijing Children's Legal Aid and Research Center
At the end of March Jeanette Satink visited the Beijing Children's Legal Aid and Research Center.
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A new building block for the quantum computer
The race to build the first quantum computer is still ongoing, but Morten Bakker has made big step forward in that process with qubits. A qubit is a unit of quantum information that can be produced in large numbers on chips. Qubits capable of exchanging photons (light particles) could be used in the…
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Inauguration computer cluster GRACE at LIACS
By making two final network connections and entering a command, Martijn Ridderbos (Deputy Chairman of the Executive Board) , Geert de Snoo (Dean of the Faculty of Science) and Bart Hoogervorst (Head of Department Operations ICT Shared Service Centre) ceremonially booted up the university’s latest supercomputer,…
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Tricking a quantum computer to enhance its performance
Researchers found a way to run programmes that should be impossible to carry out on an imperfect quantum computer. Such programmes are very computationally demanding and the quantum computers that currently exist are not yet up to that task. Unless you use a clever trick, Simon Marshall and Vedran Dunjko…
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska
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'Investigation of state aid Nike highlights need for transparency in tax rulings'
The European Commission has started an investigation into possible illegal state aid from the Netherlands to Nike. It is high time that agreements between Tax Authorities and multinationals are made public, says Associate Professor in Tax Law Jan Vleggeert.
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ALICE Leiden Computer Cluster
ALICE is Leiden University's newest computing miracle. The computing cluster is a first step in the development of infrastructure for computational and data-intensive research that is accessible to everyone within Leiden University and the LUMC. This includes both experienced users of high-performance…
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Countering nerve pain caused by chemotherapy with new drug
Nerve pain is one of the most common side effects of chemotherapy. It is therefore one of the biggest reasons for cancer patients to stop treatment early. Darcy Reynolds worked on new drug candidates against this pain during her bachelor's thesis. She developed a new series of molecules that increase…
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BioTherapeutics (MSc)
The master’s specialisation BioTherapeutics at Leiden University is a two-year programme which trains students in research in specific drug delivery techniques. The programme also examines the development of new therapeutic approaches to treat immune-based disorders, such as atherosclerosis, metabolic…
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Monitoring Cytoskeletal Conductance Variation for Sensing Cancer Drug Resistance
Actin and microtubules form cellular cytoskeletal network, which mediates cell shape, motility and proliferation and are key targets for cancer therapy. Changes in cytoskeletal organization correlate with proliferative capacity and invasiveness of cancer cells. These changes expectedly lead to altered…
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Fons Verbeek on computational bio-imaging at SleutelstadFM
Professor Fons Verbeek of the computer science and biology institutes at Leiden University has the fascination to visualize everything we can not see immediately. At SleutelstadFM he tells us that by converting 2 dimensional (2D) images to 3 dimensional (3D) structures, research is carried out into…
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Research with animals
At Leiden University, in both our biomedical and biological research, we use laboratory animals. Learn more about these specific areas of research and the goals we aim to achieve through these studies.
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From Zuidas intern to legal-aid lawyer | Leiden Lawcast S02E03
Nicolette Heijkant is our guest on the latest episode of Leiden Lawcast. Heijkant is an experienced lawyer who won her spurs working in the legal profession in Amsterdam’s business district, the Zuidas, and is now working for a legal-aid practice in Brabant. In this episode, we speak to her about her…
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Erik Danen appointed as Professor of Cancer drug target discovery
As of April 1, 2018, Erik Danen has been appointed as Professor of Cancer drug target discovery at the Leiden Academic Centre for Drug Research (LACDR). His discipline is cell biology of cancer, in which he focuses on the mechanisms underlying metastasis and therapy resistance.
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen
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How drugs work better when encapsulated in nanoparticles
Chemist Tobias Bauer discovered ways to improve drugs by encapsulating them. Packages with iron nanoparticles, for example, can stimulate immune cells. Bauer will receive his PhD on 9 June.
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Novel chemical tools for target validation in neuroinflammation
In what way can new tools and techniques be used to develop drug candidates for the treatment of neurological disorders?
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Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
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Kan een computer rechtspreken?
Kan een computer in de rechtszaal net zo goed uitspraak doen als een rechter? Hoogleraar Recht en informatica Jaap van den Herik vindt volmondig van wel. Hij legt het uit in een college van de Universiteit van Nederland.
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Santino Regilme Wins 2023 Cecil B. Currey Book Award for ‘Aid Imperium’
Salvador Santino Regilme, Jr. Associate Professor of International Relations and Program Chair of MA in International Relations, has been honored with the Cecil B. Currey Book Award for 2023. The accolade, presented by the Association for Global South Studies (AGSS), recognizes Regilme’s exceptional…
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PhDArts
Research in and through art is an inseparable part of the artistic or design practice of the researcher. Consequently, research-in-art (as opposed to research-about-art, such as art history) does not have a set goal or expected result, nor are there predetermined general procedures. The outcome of the…
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Innovation centre for drug development on Bio Science Park
International pharmaceuticals company Grünenthal is to open an innovation hub on the Leiden Bio Science Park. The hub will make it easier for scientists and drug developers to work together.
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Katja Cardol
Faculteit der Sociale Wetenschappen
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Applications of quantum annealing in combinatorial optimization
Quantum annealing belongs to a family of quantum optimization algorithms designed to solve combinatorial optimization problems using programmable quantum hardware. In this thesis, various methods are developed and tested to understand how to formulate combinatorial optimization problems for quantum…
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Algorithms for quantum software
Top scientists of three Dutch universities are working on software and systems for quantum computers. Researchers of the Leiden Institute of Advanced Computer Science (LIACS) and the Leiden Institute of Physics (LION) are developing new algorithms to make those super computers work. The coming years,…
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New professor Vedran Dunjko finds real-world problems that a quantum computer can solve
Vedran Dunjko appointed to full professor of quantum computing at Leiden University, the Netherlands.
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Karsten Lambers appointed as Professor of Digital and Computational Archaeology
In January, Dr Karsten Lambers was appointed as Professor of Digital and Computational Archaeology at Leiden University's Faculty of Archaeology. With his extensive background in both archaeological research and computational sciences, the installation of Professor Lambers further strengthens this discipline…
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Design and evaluation of video portfolios: reliability, generalizability, and validity of an authentic performance assessment for teachers
The research study presented in this dissertation focuses on issues pertaining to the reliability, generalizability, and validity of authentic performance assessments of teachers.
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Exploring Open-World Visual Understanding with Deep Learning
We are living in an information era where the amount of image and video data increases exponentially.
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LIACS part of European consortium to boost industrial quantum computing
The Leiden Institute of Advanced Computer Science (LIACS) is a proud member of the NExt ApplicationS of Quantum Computing (NEASQC) consortium, which recently received an ERC H2020 grant to stimulate the state-of-the-art in industrial quantum computing. LIACS contributes research and development of new…
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NMR structural studies of protein-small molecule interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal