The Novel chemical modalities research group is headed by Assistant Professor Sebastian Pomplun. Sebastian started at the division of Medicinal Chemistry within the LACDR in September 2021. His lab develops technologies for the discovery of novel chemical modalities that can address challenging drug…

.

Annually the Institute of Cultural Anthropology and Development Sociology awards the Speckmann prize for the best Fieldwork NL report, as well as the most accomplished master’s thesis.

Each year, the Leiden University Student Platform (LUS) presents the Leiden Education Prize.

The Austrian Studies Fund awards a prize and a stipend for talented students of Dutch and Flemish universities: the Hugo Weiland Prize and the Austrian Studies Fund Stipend.

Leiden University is involved with various grants and prizes stimulating initiatives in the field of diversity and inclusion.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics.

Leiden University regularly confers honorary doctorates, and presents awards and prizes.

On the 31 March 2022 Mr. Taufiq Hanafi successfully defended a doctoral thesis and graduated.

Uncover novel antimicrobials with prospective health benefits for sea turtles.

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

Of the 111 Spinoza Prizes that have been awarded since 1995, 28 have gone to researchers from Leiden University.

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

We are aiming to develop novel technologies to allow better sample preparation or coupling of analytical methods to (i) analyse ultra small samples, (ii) to analyse more metabolites in a quantitative manner and/or (iii) increase the sample throughput.

The Leiden Jewish Studies Association awarded the inaugural “Best Thesis in Jewish Studies” in December 2023.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. Additionally it is the main cause of birch pollen allergy in humans.

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

PhD defence

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Promotor: Prof.dr.ir. T.H. Oosterkamp, N. de Jonge

The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

Saeedeh Shahnahpur defended her thesis on 13 September 2016.

Nuran Buket Cengiz defended her thesis on 13 June 2017

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

Patients share valuable advice and experiences with their peers in online patient discussion groups.

Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

Supervisor: Andrea Martella

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Peter Bruin (PhD Leiden, September 2010) has been awarded the Stieltjes Prize for the best mathematics PhD thesis in the Netherlands. The Stieltjes Prize has been awarded each year since 1996.

This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.

PhD defence

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).

Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Can furan-based resisn be degraded by microbial enzymes in combination with mild pre-treatment?

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.