Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.

Researchers from Leiden University Medical Center (LUMC) have discovered how malaria parasites escape the immune system of mosquitoes. The so-called QC enzyme changes proteins on the outside of the malaria parasite such that the immune cells are unable to recognise the parasite. As a result, the parasite…

How has early development in R. ocellatus been modified as a result of its parasitic embryonic lifestyle?

The current resurgence of whooping cough is alarming, and improved pertussis vaccines are thought to offer a solution. Outer membrane vesicle vaccines (omvPV) are potential vaccine candidates, but omvPV-induced humoral responses have not yet been characterized in detail.

A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational…

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

Chiodo

Broad universities that focus strongly on fundamental research have the best chance of contributing to economic innovations, for example in the life and data sciences. This is the message of Professor Simcha Jong in his inaugural lecture on 14 November.

The infectious diseases malaria and tuberculosis are responsible for 2.1 million deaths every year. Leiden researchers are currently testing a new tuberculosis vaccine.

Even embryos can become embroiled in an evolutionary arms race with another species. Leiden biologists demonstrate this with larvae of the rosy bitterling that parasitize the gills of freshwater mussels. They published their research on February 19 in PNAS.

Promotores: H.A. Udo De Haes, P.M. Brakefield

How can Staphylococcus aureus bacteria subvert the host immune system?

The 2018 King's Speech was a string of statements containing little or no substance. It was obvious that, in an attempt to keep all the coalition parties happy, the speech covered more issues than in 2017. This is confirmed by an analysis of the speech carried out by public administration experts Gerard…

Matthew Broad elected a Fellow of the Royal Historical Society

Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…

From the new street language Smibanese to 17th-century manuscripts: the first national Dutch Studies Open Day explores a wide range of topics. The Open Day will take place on Saturday 7 March in Leiden. Frits Spits will broadcast his radio programme ‘De Taalstaat’ (The Language State’) from the Kamerlingh…

Health workers have always sought ways to fight disease in vulnerable groups in the population. It is now clear that such research also benefits more prosperous countries. African worm infections and innovative thermometers have shown Leiden researchers how to fight diseases of affluence and keep health…

How humans and rats cohabit the cityscape and what consequences this has for both sides of the conflict?

What is the function of the insect serosa?

Promotor: E.F. Smets Co-promotor: J. Geml

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Does roadside management in the mid-west USA increase invertebrate diversity similar to practices in Europe?

Americans more often donate funds to a presidential candidate if the campaign is backed by financiers from different, recognised social groups. This is the conclusion of Leiden researcher Vincent Traag in an article in Plos One published on 14 April.

Lecture, Com(parative) Syn(tax) Series

What are the main factors associated with the stranding of the two seal species? What are the factors influencing the prevalence of disease in the two species? Which human-related factors influence the populations of the two seal species?

Sorghum (Sorghum bicolor) is a major cereal crop that millions of subsistence farmers in Sub-Saharan Africa (SSA) rely on. However, the scourging impact of the root parasitic weed Striga (Striga hermonthica, a.k.a. “witch-weed”) has remained a major constraint hampering the productivity of sorghum in…

The Royal Netherlands Academy of Arts and Sciences (KNAW) has awarded a KNAW Early Career Partnership 2023 to Philippe van Gruisen for interdisciplinary research on (labour) migration from a broad perspective on societal wellbeing.

To discuss this question, chairmen, members, and secretaries of the Research Integrity Committees (Commissies Wetenschappelijke Integriteit, CWI) of almost all Dutch universities gathered at the Leiden Observatory on 21 April. Also present were members of the committees from Leuven, Brussels, Ghent,…

Ewine van Dishoeck was broadly covered in national and international media with her prestigious Kavli prize for astrophysics. She won 1 million dollars voor her groundbreaking work on star and planet formation and on extraterrestrial life.

Coronavirus is generating a great deal of uncertainty throughout the world. Fortunately, there are some bright spots, such as the residents of Italian cities who are in quarantine trying to keep everyone's spirits up with their clapping and singing. Closer to home, Leiden historian Suze Zijlstra took…

Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?

Can we enhance the capacity of host immune cells to kill mycobacteria via production of reactive nitrogen species?

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

In an innovative study, Radboudumc and LUMC jointly tested a candidate vaccine based on a genetically weakened malaria parasite. The results of this clinical trial, published in Science Translational Medicine, show that the vaccine is safe and elicits a defense response against a malaria infection.

In het Leids Universitair Medisch Centrum wordt gewerkt aan de ontwikkeling van een nieuw malariavaccin dat effectiever is dan de huidige vaccins.

Of the 111 Spinoza Prizes that have been awarded since 1995, 28 have gone to researchers from Leiden University.

Cyber-attacks, privacy-related problems or failures in functioning: many technologies that are used every day have security issues that are solved when the software is already in use. A new interdisciplinary project, in which Olga Gadyatskaya, Harry Wijshoff, Alex Uta and Kristian Rietveld from the…

Leiden professor of Cellular Immunology of Parasitic Infections Maria Yazdanbakhsh receives the prestigious NWO Spinoza Prize this year. This, in many ways, border-crossing scientist contributes with her research to more effective vaccines against parasitic infections and better medication for inflammatory…

When foreign matter enters our body, our immune system has to make a choice whether or not to go on the attack. There are times when the system goes wrong, and we end up with an illness or an allergic reaction. Researchers at LUMC are trying to steer the immune system. The dossier on Immunity, Infection…

For nine years he worked on the three-volume standard work Plant Galls of Europe. It yielded 2300 pages about 10,000 species of European galls, abnormal outgrowths in plants caused by parasites. Hans Roskam from the Institute of Biology Leiden: ‘The abundance of galls says something about the natural…

Drawing on a broad array of sources, this project examines modern retrievals of Bacon’s idols, thereby testing Justus von Liebig’s intriguing observation, back in 1863, that Bacon’s name lived on mainly in mottos or stereotypical phrases. More importantly, it examines the rhetorical purposes served…

Linguistic Choices in the Contemporary City focuses on how individuals navigate conversation in highly diversified contexts and provides a broad overview of state of the art research in urban sociolinguistics across the globe.

With an MSc degree in Physics you are well prepared for broad array of career prospects in research or industry and have excellent career prospects: 90% of our graduates find a job within one month after graduation. The degree is also an excellent stepping stone for pursuing a PhD degree.

Our program specializes in creative exploration and a broad understanding of scientific research and technology. It prepares students for a career involving creative and critical thinking. Our alumni have a broad choice of career prospects: they hold positions ranging from academic researcher to creative…

Three Leiden professors have recently been awarded the most prestigious scientific accolade in the Netherlands: Maria Yazdanbakhsh and Marc Koper have been awarded a Spinoza Prize and Judi Mesman a Stevin Prize. They received their prizes on 13 October.