1,146 search results for “biomarker discovery” in the Public website
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UM Cure 2020: New therapies for uveal melanoma
Can we bring novel treatment options to the clinic for UM patients with liver metastases?
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Data science
The majority of scientists, from archaeologists through to zoologists, collect enormous volumes of data. Their massive databases contain large amounts of information which is difficult for humans to filter. With a solid grounding in statistics and computer science, we can develop algorithms for analyzing…
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Quantitative Pharmacology
The Quantitative Pharmacology group headed by Coen van Hasselt focusses on the application of state-of-the-art quantitative pharmacometrics and systems pharmacology modeling combined with translational experimental models to develop personalized treatment strategies for antibiotics and to combat antimicrobial…
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Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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Role of leukocytes in metastasis formation in a zebrafish
How do macrophages and neutrophils contribute to metastatic onset?
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First discovery of methanol in a warm planet-forming disk
An international team of researchers led by Alice Booth (Leiden University, the Netherlands) have discovered methanol in the warm part of a planet-forming disk. The methanol cannot have been produced there and must have originated in the cold gas clouds from which the star and the disk formed. Thus,…
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Robust rules for prediction and description.
In this work, we attempt to answer the question:
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Health Data Science special interest group
Health Data Science Leiden University
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Predictive pharmacology
The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.
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Development of novel metabolomics & systems pharmacology concepts to realize personalized medicine
The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Awards and Grants 2020
An overview of awards and prizes granted to our staff and students in 2020, as well as special appointments at Leiden University and other institutions.
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FishForPharma: Training network on zebrafish infection models for pharmaceutical screens
How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?
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Laura Heitman
Science
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Archive
Our Talents and Discoveries is a yearly publication by the Faculty of Science of Leiden University, published since 2003. You can read all the editions online. Note that the original publication was in Dutch; the original title translates as 'What we are proud of'.
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Quantitative protein mass spectrometry for kidney injury biomarker translation towards the clinical laboratory
PhD defence
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RAD51 as biomarker for the identification of homologous recombination deficient gynaecological carcinomas
PhD defence
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Development of Machine Learning-Derived Digital Biomarkers for Trial@Home Clinical Trials
PhD defence
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Biomarkers for the response to immunotherapy in patients with non- small cell lung cancer
PhD defence
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Predictive Pharmacology
Prof. Elizabeth de Lange is concerned with the allocation of resources for the conduct of science towards the goal of best serving the public interest. Also, while she underscores that there is still the need for using animals in drug research, she is concerned about this use, and advocates the use…
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Microbial Sciences
In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.
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Dynamics of the renin-angiotensin aldosterone system in dogs: circadian variations in physiological conditions and in relation to angiotensin-converting
Promotor: Prof.dr. M. Danhof
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Systems diagnosis in chronic disease: prediction and evaluation
Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Clinical applications of (pharmaco)metabolomics
The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…
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Projects
Research projects
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Sybil-AA: Systems Biology of Alcohol Addiction
The Horizon 2020 project Sybil-AA (Systems Biology of Alcohol Addiction) focuses on modeling and validating disease state networks in human and animal brains for understanding pathophysiology, predicting outcomes and improving therapy in alcohol addiction. Alcohol addiction, the most severe form of…
- Night of Discoveries
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The quest for new medicines against tuberculosis
Can drug screening for tuberculosis treatment be made more efficient?
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Una Europa Discoveries
General Assembly
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Steffen Brünle
Science
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Mathematics student Lars Pos wins Robbert Dijkgraaf Essay Prize: 'Discoveries find their application in the most unexpected places'
With his essay 'Why science?', mathematics prodigy Lars Pos (18) won the Robbert Dijkgraaf Essay Prize. Within the theme 'The fascinating workings of science', the bachelor student wrote a plea for the societal value of fundamental scientific research. 'Because you don’t know beforehand where we can…
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Martijn van der Lienden
Science
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High-Throughput Metabolomics
Development of Comprehensive and High-throughput metabolomics techniques and Clinical applications of (pharmaco)metabolomics
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Single cell technologies for mechanobiology and mechanopharmacology
Mechanobiology is a major area in biology, however, mechanics is currently a missing element in drug development pipelines. This has led to a high cost for the society. Mechanotoxicity of drugs often appears as a long-term side effect of drugs, and has led to removal of drugs from the market. Furthermore,…
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Overview
Our research is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.
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Mast cell-mediated immune modulation in experimental Rheumatoid Arthritis and Atherosclerosis
In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.
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Medicinal Chemistry
The mission in this division, headed by Laura Heitman, is to design and synthesize novel and better ligands for drug targets. Drug discovery is a lengthy but inspiring adventure. It is often an interplay between academic institutes and pharmaceutical industry, in which scientists at university develop…
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Novel Chemical Modalities
The Novel chemical modalities research group is headed by Assistant Professor Sebastian Pomplun. Sebastian started at the division of Medicinal Chemistry within the LACDR in September 2021. His lab develops technologies for the discovery of novel chemical modalities that can address challenging drug…
- Leiden Loves Science
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Science
The Faculty of Science
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Data Science
The majority of scientists, from archaeologists through to zoologists, collect huge volumes of data. Their massive databases contain large amounts of information which is difficult for humans to filter. With a solid grounding in statistics, we can develop algorithms for analysing and identifying patterns…
- YAL at Night of Discoveries 2023
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman
- About this minor
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NMR studies of protein-small molecule and protein-peptide interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Knowledge for the public
Knowledge is everywhere at Leiden University. It is also accessible for those who do not study or work at the University.
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About the programme
Drug Discovery and Safety consists of 120 European Credit Transfer System (EC) points.
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Career prospects
In the Master’s programme in Bio-Pharmaceutical Sciences of Leiden University you are trained for a scientific career in drug research and development.