Patients share valuable advice and experiences with their peers in online patient discussion groups.

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

Regenerative medicine is a new way of treatment that helps impaired cells, tissues, and organs work well again. We do this by repairing, replacing, or restoring cells, tissues, and organs after damage from illness or injury. This includes treating long-term diseases such as diabetes, kidney diseases,…

Promoting sustained physical activity through tailored incentive-based interventions for diverse cardiovascular disease patient groups.

Which criteria do ED patients and therapists evaluate as most relevant for recovery? Do patients and therapists differ in their evaluations? Do eating disorder patients differ from a healthy control group in their scores on the Recovery Scale?

This project develops a scientific method to extract clinically relevant new information from patient forum websites that discuss patient experiences concerning e.g. medication, nutrition, co-morbidities, genetic factors etc.

Imagine that you have a chronic skin condition, characterized by red patches of itchy, scaly skin. You regularly notice people staring at your skin and sense their reluctance to shake your hand. Or imagine that you have Parkinson's Disease, causing your hands to tremble and making it difficult for you…

Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…

This study aims to explore the use of a behavioral-design-based approach in simulating patient flow through EMTs. It provides a dynamic behavioral simulation model to assess the interactions between patients, staff members, and the related dynamic movements/interactions with the health care facility,…

The major aim is to develop, evaluate, and implement disease-generic cognitive-behavioral interventions through the internet in order to optimize tailored health care for patients with chronic somatic conditions.

The aim of this project is to develop, evaluate, and multicentre implement a blended form of cardiac rehabilitation that uses a theory-based approach to guide patients to full self-management.

How does stress affect different components of behavioral impulsivity and aggression in patients with Borderline Personality Disorder compared to clinical controls (patients with Attention Deficit Hyperactivity Disorder) and healthy controls?

Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).

This book investigates the effects of brain lesions in the left hemisphere, specifically Broca's area, on the production and perception of vowels, of word tones and of the linguistic use of sentence melody.

Become involved with LUGO! Become part of the team, join forces with fellow committee members in our voluntary committee or take part in our project-based internships! Check this page regularly for open positions.

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

In the Netherlands, as elsewhere in the world, many patients who are in a palliative care trajectory prefer not to receive full or explicit medical information. This is more often the case for patients with ethnic or cultural minority backgrounds. As open-information provision is the norm, non-disclosure…

The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).

Always had an interest in working with children and then doing a masters focusing on the elderly. Sounds strange? Not for Medicine master's student Anna Suurmeijer. With the knowledge she gained during the waiting period for her fellowships, she developed a broader view (and not only in the medical…

We aim to create an innovative e-learning and virtual reality training that helps healthcare providers to optimize placebo effects and minimizes nocebo effects via their communication.

The WIIS network is about the advancement of women's leadership. To best accomplish our mission, we need subscribers like you. As a dues-paying subscribers of Women In International Security (WIIS), you will have the ability to contribute to the WIIS Blog, receive WIIS this Week, access and post to…

An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfill a predominant role in the skin barrier function.

OBJECTIVES: To determine whether the lipid/protein ratio and the total dry SC mass per surface area are related with the skin barrier function of controls and AE patients.

Chronic inflammatory skin diseases such as psoriasis and atopic dermatitis affect both the physical and psychological well-being of millions of patients, leading to persistent symptoms like itchiness and sleeplessness. These conditions often result in decreased productivity and quality of life overall,…

Welcome to the Leiden Science community! Throughout the year, our faculty hosts a range of events designed to bring together students and staff. From interesting lectures to lively gatherings and ceremonial milestones, there’s always something happening for you. Explore the upcoming events and make…

Amir Zamanipoor Najafabadi, a doctor and researcher at the LUMC’s Department of Neurosurgery, researches how meningioma treatment can have a long-term effect on a patient’s life. He recently defended his dissertation: with a patient on the examining committee, this was a unique occasion.

The right medicine in the right dosage for every patient, that is something medical science aspires. 'Personalised medicine' is the term for that. But it does require a lot of research with patient data and that can be hard to get due to privacy legislation. Researchers Laura Zwep and Coen van Hasselt…

Patients with incurable cancer want their oncologist to be clear but to show empathy too. They find hard and vague communication harmful. These are the results of a study by psychologists from Leiden that has been published in the American journal Cancer.

The Liverpool care pathway for the dying patient (LCP) is a multidisciplinary tool developed for the dying phase for use in palliative care settings. The literature reports divergent experiences with its application in a nursing home setting related to its implementation and staff competencies. The…

Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…

To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

Researchers at the Leiden Institute of Advanced Computer Science (LIACS) are collaborating on the development of a conversation tool for patients with breast, prostate and skin cancer. The aim is to create a conversation tool that can support cancer patients in their care and help them make decisions.…

Tom Buitelaar is an Assistant Professor in the War, Peace & Justice programme of the Institute of Security and Global Affairs. This paper discusses four important challenges to the involvement of UN peace operations in international criminal justice: its effects on host state relations, peace and justice…

PhD research recently completed by pharmacologist Margreke Brill shows that morbidly obese patients should be given a different dosage of the drugs Cefazolin and Midazolam. This could also apply to other drugs such as anti-cancer drugs as well as antibiotics and Margreke Brill is advocating a change…

Examining mediation and moderation.

Does medicine make patients feel better or worse? We are getting better at predicting this from people’s DNA profiles, says Professor Jesse Swen. ‘It never fails to fascinate me how one DNA base pair can have such a huge effect on treatment with medication and the outcome.’

Navigation Lab Leiden has launched a study on the effects of the navigation training program we have developed, called Wayfinder. Milan van der Kuil is the main researcher on this project and studies how navigation ability can be improved in patients with acquired brain injury.

Marta Fiocco has been appointed as of 1 April as professor of applied mathematics, in particular medical statistics. Fiocco's appointment is at the Faculty of Science and at the Leiden University Medical Centre (LUMC). She conducts research into 'personalised medicine', tailor-made medicines for cancer…

Patients with certain diseases discuss their experiences and support one another on specialised internet forums. With the right data-science methods, these forums can be a goldmine of information for researchers. PhD candidate Anne Dirkson is researching these methods.

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Menzo Havenga, CEO of Batavia Biosciences on the Leiden Bio Science Park (LBSP), has a favourite hobbyhorse: the Clinical Development Board. The aim of this board is to make sure that high-impact research results in high-value products that will benefit patients.

Patients on patient forums share all sorts of things about their illness: from side effects and advice to messages of support. PhD candidate Anne Dirkson uses artificial intelligence (AI) to retrieve this information. ‘Ninety per cent of the side effects weren’t officially registered.’

The AtheroNeth consortium received €6 million from the Dutch Heart Foundation to gain a better understanding of the differences in disease progression among patients with atherosclerosis. The ultimate goal is to enable personalised treatment.

A therapeutic vaccine against HPV-16 (type 16 human papillomavirus) improves the survival rate in cervical cancer patients. A new study by ISA Pharmaceuticals B.V. (a Leiden-based biotechnology company) and the Leiden University Medical Center (LUMC) shows that this vaccine produces a more robust response…

A new AI model will soon be able to predict the risk of infection in postoperative patients. This will allow healthcare providers to take preventive measures and detect complications at an earlier stage.

Doctors should work with patients with bone and soft-tissue tumours to find the best personal treatment strategy says Prof. Michiel den de Sande. He has developed an app that helps choose the right treatment. Van de Sande was appointed Professor of Orthopaedics with a particular focus on paediatric…

Patients with incurable breast cancer remember more information about their treatment if their doctor is more empathetic during consultations. These are the results of research by psychologists from Leiden University in collaboration with Nivel research institute. Publication in Patient Education and…

A group of patients were given a guided tour of the larger than life Rembrandt canvases on University buildings around the Rapenburg canal. This was with the help of students from Present, a volunteer organisation, who pushed their wheelchairs over the bumpy cobblestones. The canvases are on show until…

Heart patients who maintain a healthy lifestyle can start earning discounts at shops or for trips out. The Tergooi Hospital is the first in the Netherlands to introduce this unique method that was co-developed by the research group headed by Professor of Health Psychology Andrea Evers and the Leiden…