2,512 search results for “computer aided drug design” in the Public website
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LUMC involved in development of novel drugs to treat and prevent SARS-CoV-2 and other coronaviruses
The Department of Medical Microbiology at Leiden University Medical Center (LUMC) is researching antiviral drugs that could treat and prevent SARS-CoV-2 in various projects. One part of the PanCoroNed project is being led by Martijn van Hemert and involves lab tests into the antiviral effect of molecules…
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Tim van Erven makes computers even smarter
In high school, Tim van Erven read about an artificially intelligent algorithm that could solve mazes. From that moment on, he was sold: ‘There’s something magical about algorithms. With a list of fixed rules you can make them learn the most diverse things.’ This year, he won a Vidi grant, which he…
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Ovalbumin coated pH-sensitive microneedle arrays effectively induce ovalbumin-specific antibody and T-cell responses in mice
The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…
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Does Trump have the authority to single-handedly take on Mexican drug cartels?
The American president Trump is considering military intervention in Mexico to get rid of the drug cartels once and for all, but Mexico is not interested in other countries' interventions. According to Jelle van Buuren, Assistant Professor at the Institute of Security and Global Affairs, Trump's much…
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The hunt for the best computer language
Our language is adapted to the context in which we humans communicate. But computers ‘think’ differently. What would a language be like whose structure was optimally adjusted for use by humans and machines? Tessa Verhoef is trying to find the answer.
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LEELIS Conference on future of computer chips
A collaboration of physicists and chemists organized the LEELIS conference on new computer chip technology in Amsterdam on 10-11 November. Leiden physicist Joost Frenken is director of the organizing institute ARCNL.
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The hunt for the best computer language
Our language is adapted to the context in which we humans communicate. But computers ‘think’ differently. What is the optimal form of a language for human-machine communication? Tessa Verhoef is trying to find the answer.
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Knowledge extraction in the quantum random-oracle model
The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.
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Annemarie Samuels
Faculteit der Sociale Wetenschappen
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Hilde van Meegdenburg
Faculteit der Sociale Wetenschappen
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Marcello Bonsangue
Science
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Juan Claramunt Gonzalez
Faculteit der Sociale Wetenschappen
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Diego Barbosa Arize Santos
Faculteit der Sociale Wetenschappen
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Charles Berger
Faculteit Rechtsgeleerdheid
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Arend-Jan Quist
Science
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Francesco Buda
Science
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Wessel Kraaij
Science
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Archaeology thanks to computer-based research
A mix of data research, artificial intelligence and archaeology led to lively discussions on 31 January. On that day the unique event 'AI & Data Science @ Archaeology' took place in which the Data Science Research Programme (DSRP), SAILS and the Faculty of Archaeology joined forces.
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3 October University: from Russian DNA to drug-related violence
In prehistoric times there was a huge wave of migration, from the steppes in Russia and Ukraine to West Europe. The newcomers’ genes began to dominate. Archaeology research in Leiden into burial mounds in the Veluwe and Utrechtse Heuvelrug areas of the Netherlands yielded this spectacular conclusion.…
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Algorithms help improve building design
Modern optimization algorithms offer solutions for architectural decisions like spatial, structural and energy efficiency. A young computer scientist from Leiden University co-authored a paper that won the Best Paper Award at a leading conference in Krakow during the summer.
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Wesseling on The Device Paradigm and Contemporary Practices in Art and Design
On May 18 Janneke Wesseling gave a lecture at the conference
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Interactions in Designer Materials Unveiled
Graphene and other layered materials combine into completely new substances. Leiden physicists establish the ground rules for designing such materials by measuring how the layers in the stack interact. Publication on November 29 in Nature Communications.
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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A computer made of floppy rubber
A piece of corrugated rubber can function as a simple computer, displaying memory and displaying the ability to count to two. Leiden physicists describe the computing rubber in the journal PNAS. ‘Simple materials can process information, and we want to find the principles behind that.’
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Orbiting black holes explained with super computer
Two black holes, in close orbit around each other. Have they slowly drifted together, or did they emerge from two orbiting stars? Together with to colleagues form Amsterdam, Leiden astronomer Simon Portegies Zwart calculated that the second scenario is rather likely.
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Biophysical characterization of membrane protein-small molecule interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Light-activatable metallodrugs and metal-functionalized liposomes
Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…
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COMMUNITY: unraveling the regulatory networks in Streptomyces that switch on antibiotic production on demand
Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics
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Hora est through a computer speaker: Leiden’s first fully online PhD defence
Samineh Bagheri is the first PhD candidate to defend her thesis fully remotely.
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What's Next? Interactive and immersive design
With the What's Next? series we hope to inspire current Media Technology MSc students, show the variety of paths taken after the studies, and bring together alumni. Editions of the series are generally organized around a particular theme by Media Technology MSc students themselves, and followed by social…
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Social Forces, States and Hydropolitics of the River Nile: Case Studies of Egypt, Ethiopia, Sudan
This research aims to investigate how different social forces interact with hydropolitics in the Eastern Nile Basin and what are the constraints of engagement.
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Dental remains shed light on drug use in 19th century Dutch village
Archaeologist Bjørn Peare Barthold suspected farmers in a doctorless 19th century Dutch village may have been self-medicating to manage pain and disease. By examining the skeletons' dental calculus this hypothesis could be tested. Science Magazine interviewed him about this new technique.
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Interaction with sound for participatory systems and data sonification
This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.
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Workshop: Interdisciplinary Research Design for Global Studies
What does it mean to do “global research”? Global studies is an emerging field that focuses on transboundary, international, and global processes and systems, such as climate change, global social media, and globalization. These issues call for researchers to think beyond conventional state actors or…
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Champion in headwind and predictions
It is a stormy Sunday afternoon, with gusts of a whopping 110 kilometres per hour. Chemist Teun Sweere defies the enormous headwind on his city bike and wins the NK Headwind cycling after 22,5 minutes. A new highlight follows six months later: his PhD defence (14 June).
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COVID-19 Research and Education at Leiden Academic Centre for Drug Research
Since the start of the Corona crisis, several COVID-19 related research and teaching projects were started at LACDR. The computational and teaching activities started right away, as well as a large-scale metabolomics screening program by Thomas Hankemeier’s group. Other experimental activities are still…
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Hackers and Designers Summer Academy 2020
Hackers and Designers Summer Academy 2020 will take place remotely from July 20-25
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Strategies for braiding and ground state preparation in digital quantum hardware
With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.
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Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
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Multistakeholderism: Prospects of an Institutional Design
On 8 April 2022, Jan Aart Scholte gave a keynote lecture on ‘Multistakeholderism: Prospects of an Institutional Design’ at the T.M.C. Asser Institute.
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Drugs for our immune system in the right place at the right time
Immunologist Leender Trouw specialises in the complement system, which is part of the immune system. In some diseases drugs help activate or inhibit this system. This is best done ‘in the right place at the right time’ − the title of his inaugural lecture.
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Designing a smart city together
How can we make clever use of new technologies to improve quality of life in cities? The answer is in the NL Smart City Strategy, which Mark Rutte officially received on January 25th. Three professors from Leiden University - Carolien Rieffe, Joost Kok and Wessel Kraaij - gave advice.
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Rob van Nieuwpoort new professor of Efficient Computing and eScience
As of 1 October Rob van Nieuwpoort is the new professor of Efficient Computing and eScience at the Leiden Institute of Advanced Computer Science (LIACS). Van Nieuwpoort brings with him a wealth of expertise: he is an expert in eScience, high performace computing and advanced algorithms.
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Computer Science in Leiden offers highest quality education
The Keuzegids Universiteiten 2018 has labelled the master’s programme in Computer Science as a “Topopleiding”, because it fulfils the highest standards. The Leiden programme ranks highest on the list of Computer Science programmes in the Netherlands.
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ESO instrument METIS passes important design milestone
The METIS instrument that’s being built for ESO's future Extremely Large Telescope (ELT) in Northern Chile under the leadership of the Dutch Research School for Astronomy (NOVA) has reached an important milestone: the preliminary design has been approved.
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Archaeology thanks to computer-based research
A mix of data research, artificial intelligence and archaeology led to lively discussions on 31 January. On that day the unique event 'AI & Data Science @ Archaeology' took place in which the Data Science Research Programme (DSRP), SAILS and the Faculty of Archaeology joined forces.
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‘The first quantum computer will fill a sports hall’
The worldwide race to the quantum computer is in full swing. This computer can bring about a breakthrough in discovering medicines and new materials. Leiden researchers, together with the TU Delft, are taking part in the race. There is now a dossier online about their work.
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Smart design carries sound one way
A new computer simulation shows the promising possibilities of the booming field of topology. Smartly designed mechanical structures carry sound exclusively one way and are immune to fabrication errors. Publication on 17 July in Nature Physics.
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Quantum computing pioneer Seth Lloyd is the 2019 Lorentz Professor
American physicist and quantum computing pioneer Seth Lloyd is the 65th Lorentz professor. He will deliver the Ehrenfest lecture on 5 June, and several more lectures on quantum computing on 11, 18 and 25 June.
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Master Computer Science in Leiden nr.1 according to Elsevier
Master Computer Science in Leiden nr.1 according to Elsevier