Throughout all domains of life, from bacteria and archaea to eukaryotes, genomes adopt well-organized three-dimensional structures that can change in space and time to accommodate preferred transcriptional programs for environmental adaptation, the maintenance of cellular identity and differentiation…

The Graduate School at the University of Notre Dame accepts up to two, funded (tuition scholarship + full stipend) PhD students per year in Liturgical Studies. The program integrates three sub-disciplines: Liturgical History; Liturgical Theology; Ritual Studies. Deadline: 2 January 2023.

How do our cells keep DNA stored away? To find out, biochemist Remus Dame received a 3 million euro Science-Groot grant. Leiden University will share the grant with TU Delft, VU Amsterdam and the Hubrecht Institute.

On Friday October 30th 2015 the sixth annual Jan Reedijk Symposium will be held. The main lectures of the day will be

Key research articles and book chapters of the Chromatin group.

Some bacteria, it turns out, have proteins much like ours that organise the DNA in their cells. They just do it a bit differently. This is revealed by new research from biochemists at the Leiden Institute of Chemistry and the Max Planck Institute for Biology. The discovery helps us better understand…

Relevant publications of the CIGR participants.

Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Aimee Boyle, Lars Jeuken and Anne Wentink.

The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…

Now online in Molecular Microbiology our studies on the motility of Sulfolobus acidocaldarius and its unique swimming organelle, the archaellum.

Find out more about our national and international research collaborations.

The following sources were consulted for this guide:

Authoritative and cutting-edge, Bacterial Chromatin: Methods and Protocols aims to be useful as an up-to-date reference work for scholars in the bacterial chromatin field, those entering the field from adjacent research fields, and scientists in the eukaryotic chromatin field.

Our group operates at the cross-roads of different disciplines: molecular and cellular microbiology, biochemistry, structural biology and biophysics. The group harbors expertise in a multitude of molecular and cellular approaches including:

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

The CIGR comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).

The CMCB comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC) and the Leiden University Medical Center (LUMC).

The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny…

This book challenges the predominance of mainstream sociolinguistic theories by focusing on lesser known sociolinguistic systems.

Promotor: Prof.dr. J. Brouwer, Co-promotor: Dr. Remus Th. Dame

Leiden University has made history with its many scientific discoveries; a history that is also illustrated in a variety of books and films.

The CMCB brings together microbial cell biology expertise in Leiden. It aims at optimal resonance between the groups and maximal exploitation of the available infrastructure and to develop innovative cross-boundary technology platforms.

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine.

Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).

What are the principles of genome folding and dynamics in bacteria?

Leiden University has a rich history in the domain of Papyrology. Papyrology+, founded in 2014, is a collaboration of Leiden scholars studying (Abnormal) Hieratic, Demotic, Aramaic, Greek, Latin, Coptic, and Arabic papyri from a socio-historical, economic and linguistic perspective.

Leiden University was the first university to be established in the Netherlands. William of Orange gave Leiden Academia Lugduno Batava in 1575, it is said in recognition of the city’s courageous resistance against the seige by the Spanish invaders.

Archaeobotanic research by prof. dr. C. Bakels and students on agriculture.

With Sylvestre Bonnet, Jeroen Codée and Remus Dame, the Leiden Institute of Chemistry (LIC) will be getting no less than three new professors. Bonnet will become professor in Bioinorganic Chemistry, Codée professor in Organic Chemistry and Dame professor in Molecular and Cellular Biochemistry.

Subproject of

Good research means looking beyond disciplinary boundaries, said Professor of Molecular and Cellular Biochemistry Remus Dame in his inaugural lecture on 10 May. Processes that take place on DNA shouldn’t only be researched in a test tube but also in living cells, for instance.

At the Dies Natalis Willem Otterspeer, Professor Emeritus of University History, presented the fourth and final volume of Groepsportret met Dame, his series on the history of Leiden University. De 'Strategie van de Aanpassing' covers the period 1876-1975. Otterspeer talked about his book in a podcast…

Dutch researchers have developed a new tool to label DNA for studying chromosomes in live cells. The tool is non-invasive and can be applied in culture but also in living organisms, such as zebrafish embryos. The team published their findings in the journal Nucleic Acids Research.

For the first time, it was shown in living cells how the bacterium E. coli regulates genes that help it survive in a new environment. Biochemist Fatema Zahra Rashid managed to do this using a technique she fine-tuned. Her research into changes in 3-dimensional chromosome structure offers clues for ways…

Research at the Macromolecular Biochemistry group is comprised of the following research themes:

The Cleveringa chair was installed by Leiden University in memory of Professor Rudolph Pabus Cleveringa and the courage he demonstrated in November 1940 during the German occupation (1940-1945). It also commemorates the liberation of the Netherlands in 1945.

The Secular Outlook describes what moral and political secularism means. It paints the image of a world view in which state and religion are kept well separated.

Professor Corinne Hofman has been made a Corresponding Fellow of the British Academy for the humanities and social sciences. She is among 76 distinguished scholars to be elected to the fellowship in recognition of her work in the field of archaeology.

An overview of awards and prizes granted to our staff and students in 2020, as well as special appointments at Leiden University and other institutions.

On 10 March 2023, the Amsterdam Centre for Tax Law (ACTL) of the University of Amsterdam (UvA) organised the Conference ‘Towards eXplainable Artificial Intelligence (XAI) in Taxation: The Future of Good Tax Governanceon’.

Over 170 people took part in the panel on current events in Iran organized by LUCIS. A bustling crowd of Dutch-Iranians, students, University staff, and others came to listen to the panel of journalists and researchers in the illustrious Lorentzzaal.

Emeritus professor Willem Otterspeer received a royal honour from mayor Henri Lenferink on Tuesday 20 September. The university historian was appointed Knight of the Order of Orange-Nassau.

The biographer of Leiden University, Willem Otterspeer, has a new book out. In ‘De stad, de dood en de dichters’ (The City, Death and the Poets) he combines his love for the University and poetry with autobiographical reflections. ‘With my magnifying glass I discovered yet more new details in the pr…

The intestinal bacterium E. coli can adapt to changes in its surroundings. Leiden scientists have discovered how the H-NS protein makes this possible. This new knowledge can be an important starting point in combatting bacteria and diseases such as peritonitis. Publication 2 October in the journal e…

The Global Summit, which took place from 12-16 January 2021, is an initiative by Richard Albert, the William Stamps Farish Professor in Law, Professor of Government, Director of Constitutional Studies at the University of Texas at Austin, and Founder & Director of the International Forum on the Future…

Leiden scientists are the main applicants for five projects that have been awarded a Science Groot grant of up to 3 million euros in the Science Domain. In addition, several Leiden scientists are involved in other projects that have been awarded funding.

Seven Leiden researchers have been awarded a prestigious Vici grant by the Netherlands Organisation for Scientific Research (NWO).