In this thesis, we investigate how deep generative models (AI models that can create new designs) can be better utilized for technical and industrial design. Our goal is to generate designs that are not only realistic (plausible), but also efficient, reliable, and usable in complex 2D and 3D applica…

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Its idyllic setting and white sandy beaches have made the Maldives a hotspot for tourists. This provides an income but is a problem for the fragile natural environment. Students from various universities worked with the local people to make the soil more fertile. How did they go about it?

Promotor: Prof.dr. T.H.W. Bäck

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron, Co-Promotor: P. van der Putten

Higher design and engineering educators have different views on what a new or renewed curriculum should entail, content-wise as well as pedagogically. This research aims to describe how these ‘curriculum perspective perceptions’ influence working definitions, end goal formulation, and the scope of results…

Advances in the field of high-performance Nd-Fe-B permanent magnets, by re-engineering their microstructure to make them more powerful while reducing rare earth content.

Bandura Witharana defended his thesis on 27 September 2018

Healthcare Information Systems (HIS) are essential for modern healthcare delivery, yet their development faces significant challenges including heterogeneous data formats, regulatory compliance, and the growing demand for AI-driven decision support.

A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

Apps that can precisely identify shards, coins or heel bones: archaeology has embraced artificial intelligence. Alex Brandsen is working on a search engine that scans vast quantities of text from an archaeological viewpoint.

An examination of academic organization at the forefront of the biotechnology revolution

Engineered nanomaterials (ENMs) are widely used, and nanotechnological innovations grow with rapid pace. Studies on nanotoxicology have demonstrated that chemical toxicology as well as particle toxicology should be accounted for in predicting the safety of ENMs.

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

The discussion on employability of higher education graduates has been around for several years, with more emphasis in the 21st century. Yet, universities are still challenged in the pursuit of providing work-ready graduates who can meet industry expectations.

The remains of Dutch East India Company forts are scattered throughout littoral Asia and Africa. But how important were the specific characteristics of European bastion-trace fortifications to early modern European expansion?

This thesis examines enzyme domain architecture and engineering to improve the breakdown of lignocellulose and starch, abundant biopolymers crucial for sustainable biofuel and biochemical production. Carbohydrate-active enzymes (CAZymes) facilitate this degradation, but the structural complexity of…

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

A single self-assembled semiconductor quantum dot in a high-finesse optical microcavity - the subject of this thesis - is an interesting quantum-mechanical system for future quantum applications. For instance, this system allows trapping of an extra electron and thus can serve as a spin quantum memory,…

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

The findings in this thesis improve the understanding of 1) the relationship between exposure characteristics and toxicity of ENPs, 2) the joint toxic action of ENP mixtures and the comparison to metal salt mixtures, 3) how NOM affects the individual and joint toxicity of ENPs, 4) the extent of trophic…

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Immune system defends our body against pathogens and cancerous cells, but excessive immunity can in turn lead to tissue damages and diseases. For example, scratching the surface of the eye ignites an immune response that aims at preventing infection but can also lead to edema, angiogenesis and eventually…

Can bacteria be engineered to convert methanol into valuable chemicals with high efficiency?

Water droplets float in a hot pan because of the so-called Leidenfrost effect. Now physicists have discovered a variation: the Elastic Leidenfrost effect. It explains why hydrogel balls jump around on a hot plate making high pitched sounds. Publication in Nature Physics on July 24.

Search engines are getting better at answering our questions. And chatbots are increasingly likely to search the internet for relevant sources. ‘Search engines and chatbots will become more closely entwined’, says Professor Suzan Verberne.

Promotor: Prof.dr. R.M.H. Merks

Can Cyanobacteria be engineered to convert the greenhouse gas carbon dioxide into the valuable chemical isoprene?

Brandon Zicha (Leiden University College The Hague) had always been critical of the teaching system at universities. But it was only when he passed the Senior Teaching Qualification at the end of last year that he was able to explain exactly what was wrong with it.

Plastics have become an integral part of modern society due to their versatility and durability.

These are the staff members of the Leiden - Latin America and the Caribbean Centre

The project results and dissemination activities listed here below are the results at the closure of the ICM 2019 project (Summer 2022).

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.