The Microscopy Unit houses, maintains and coordinates most of the microscopy equipment of the IBL. The available equipment ranges from conventional light and fluorescence microscopes, to confocal laser scanning and electron microscopes. In addition, infrastructure is available for histology, including…

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Promotor: T. Schmidt

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.

This is a yearly event where we move in one week from the physics of light through the composition of the microscope, fluorescence microscopy and end up with some image analysis All the lectures are backed by practicals to really put your obtained knowledge into practice

Leiden University, together with Utrecht University, the LUMC and 10 other Dutch universities and institutes, has been awarded a grant of more than €30 million in the NWO call Roadmap Large-scale Scientific Infrastructure (GWI).

Electron microscopy has become an extremely important techniquein a wide variety of elds.

This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

The aim of this facility is to accelerate biomedical research by providing access to advanced light and electron microscopy and by sharing expertise about sample preparation, imaging modalities, data storage and image analysis.

This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

In this thesis we use Josephson and noise scanning tunneling microscopy for the study of conventional, unconventional (iron-based) and disordered superconductors. On the one hand, Josephson scanning tunneling microscopy allows us to directly visualize the superfluid density with high spatial resolut…

Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.

In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…

In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

International trade plays a critical role in global food security, with global consumption having highly localized environmental impacts.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

Promotores: Prof.dr. C.U. Keller, Prof.dr. H.C. Gerritsen

Promotor: T.H. Oosterkamp

ChEMBL is a large-scale drug discovery database containing bioactivity information primarily extracted from scientific literature.

We explore the possibilities to combine magnetic resonance techniques with atomic force microscopy together in a single microscope: the MRI-AFM, also called Magnetic Resonance Force Microscopy (MRFM).

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.

A small number of EC points from your elective space can be obtained through project work instead of taking elective courses. This enables students to work on a project that they really want to do.

Elective courses enable students to gain deeper insight into scientific topics of their choice, and they prepare students for their individual graduation project. They can be elected from Leiden University, but also from other (inter)national universities.

Electives offer students the opportunity to further specialise and deepen in specific aspects of leadership.

PhD defence

Leiden University values participation: the participation organs are the ears and eyes of the university. They identify issues of concern among staff and students and help advise and decide on the future of our organisation. Something for you? Then stand as a candidate! This year, elections will…

High throughput microscopy

Does your programme have an elective space of only 15EC? Then you can follow a modified programme of the American Studies minor, which we call 'Elective credits'.

The dissertation describes TEM experiments on heterogeneous catalysts.

In this thesis, we develop a novel technique called Optical Near-field Electron Microscopy (ONEM), which aims to combine the advantages of both optical and electron microscopy: the high resolution of electron microscopy and the low sample damage of optical microscopy.

Identifying natural plant-associated bacteria that provide targeted inhibition of pathogens through the production of antimicrobial peptides.

As a student or staff member, you can stand as a candidate for two participatory bodies: the Faculty Council of Humanities and the University Council. In both cases, you represent the interests of students and staff members and contribute ideas to policy. Are you considering standing as a candidate…

The purpose of this study was to investigate the formation and growth kinetics of complexes between proteins and oppositely charged polyelectrolytes.

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

With the University Council elections approaching, the Leiden University Green Office (LUGO), with the support of LU's Central Sustainability Team and the D&I Office, contacted all seven candidate parties to inform our community about their views on sustainability and diversity. We asked each party…

The INTERACT project strive to unlock the enormous biotechnological potential of microbes, leading to sustainable crop productions systems.

LUCDH offers 5 faculty-wide elective courses to improve your practical skills and thinking about digital tools and media. These courses are open and useful for all students of the Humanities.

LUCDH offers five elective courses to improve your practical skills and thinking about digital tools and media. These courses are open and useful for all students of the Humanities.

To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

The Netherlands Organisation for Scientific Research (NWO) has made a subsidy of 17 million euros available to further develop a Netherlands network for electron microscopy (NEMI). The network comprises five UMCs and eight universities, with Utrecht in the coordinating role. From Leiden, the Institute…

In this article, Madeleine Hosli, Professor of International Relations at the Institute of Security and Global Affairs, and Jaroslaw Kantorowicz, Assistant Professor at the Institute of Security and Global affairs, discusses the relevance of structural variables in a time where European politics are…