1,946 search results for “this week E2 80 99s discoveries” in the Public website
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LED3 Lecture: Molecular glues in drug discovery
Lecture
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The chlorine chain study
A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.
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Curious Minds
At the Leiden Curious Minds Centre, our research focuses on the relationship of exploratory behaviour and discovery learning to curiosity and the way children regulate their behaviour and emotions. We want to improve our understanding of how children can and do become more and more the captain of their…
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Plan B for particle physics: finding long lived particles at CERN
This thesis discusses the discovery potential of Intensity Frontier experiments.
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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The activation mechanisms of G protein-coupled receptors: the case of the adenosine A2B and HCA2/3 receptors
Promotor: A.P. IJzerman
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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Contact
The Grotius Centre for International Legal Studies has offices in Leiden (Kamerlingh Onnes Building) and in The Hague (Wijnhaven Building | Campus Den Haag).
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Contact
The Faculty of Governance and Global Affairs is situated at three locations in The Hague's city centre.
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Reception Wijnhaven
Wijnhaven, Turfmarkt 99, 2511 DP, The Hague
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Asia Academy #11: South Korea's Chip Power
Lecture, LAC Asia Academy
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Plexus Student Centre
Kaiserstraat 25, Leiden
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Master Population Health Management
Do you want to contribute to a more intergrated health care system? In the two-years Master Population Health Management, knowledge insights from epidemiology, data analysis in healthcare, medicine, public administration and behavioral sciences are combined into a globally unique interdisciplinary programme.…
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Contact
If you have a question, there are various ways to get in touch with us.
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Contact
If you have a question, there are various ways to get in touch with us.
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Contact
If you have a question, there are various ways to get in touch with us.
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Contact
If you have a question, there are various ways to get in touch with us.
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Contact
If you have a question, there are various ways to get in touch with us.
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If you have a question, there are various ways to get in touch with us.
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Contact
If you have a question, there are various ways to get in touch with us.
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Contact
If you have a question, you can get in touch with us in a variety of ways.
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Master Population Health Management
Do you want to contribute to a more intergrated health care system? In the two-years Master Population Health Management, knowledge insights from epidemiology, data analysis in healthcare, medicine, public administration and behavioral sciences are combined into a globally unique interdisciplinary programme.…
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Contact
If you have a question, there are various ways to get in touch with us.
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Contact
If you have a question, there are various ways to get in touch with us.
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Contact
If you have a question, there are various ways to get in touch with us.
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Choose your study
At Leiden University you can choose from 16 English-taught bachelor’s and 250 English-taught master’s programmes. We enjoy an excellent worldwide reputation accumulated over more than four centuries. Today we’re consistently highly placed in major rankings, such as The Times Higher Education, QS and…
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Contact
If you have a question, there are various ways to get in touch with us.
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Contact
If you have a question, there are various ways to get in touch with us.
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Contact
If you have a question, there are various ways to get in touch with us.
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Programme structure
The SCS courses train you in practical and theoretical aspects of science communications. Internships help you decide whether you want to choose a career in science communication or Computer Science.
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Contact
If you have a question, there are various ways to get in touch with us.
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Contact
If you have a question, there are various ways to get in touch with us.
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Contact
If you have a question, there are various ways to get in touch with us.
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Using AI to improve the Design-Make-Test cycle with Galapagos
Researchers at LED3 are working together with biopharmaceutical company Galapagos to develop software for use in early drug discovery (funded by NWO). This software is able to design molecules with several simultaneously optimized characteristics and will also take prediction reliability into consideration…
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To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…
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Flagships
In CCLS several subgroups have formed, below you can find an overview of these groups with the names of the leading researchers and a short outline of the project.
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Molecular Pharmacology
In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…
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Cell Systems and Drug Safety
The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…
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Tom van der Wel
Science
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CEEDs, the Collective Experience of Empathic Data Systems
The Collective Experience of Empathic Data Systems (CEEDs) consortium developed novel integrated technologies that support experiencing, analysing and understanding of very large datasets.
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Witnessing the Process of Bacterial Cell Death: Novel Antimicrobials and Their Mechanisms of Action
This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…
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Spectroscopic characterization of exoplanets: From LOUPE to SINFONI
Over the past years it has been discovered that the population of extra-solar planets is large and diverse.
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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Societal impact
Research from the Living Lab is important for society. For example, scientists from the Living Lab discovered that the pesticide thiacloprid is up to 2,500 times more harmful to insects than was thought on the basis of regular lab research. Partly because of this discovery, the European Commission decided…
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Beyond the Site
The Saalian archaeological record at Maastricht-Belvédère (the Netherlands).
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Get involved
The WIIS network is about the advancement of women's leadership. To best accomplish our mission, we need subscribers like you. As a dues-paying subscribers of Women In International Security (WIIS), you will have the ability to contribute to the WIIS Blog, receive WIIS this Week, access and post to…
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Luuk van Middelaar launches his new book in London at LSE and UCL
This week, Prof. Luuk van Middelaar (Europa Institute) publishes Alarums & Excursions: improvising Politics on the Europen Stage – a revised update of his 2017 book on the decade of EU crises.