1,879 search results for “computer aided drug design” in the Public website
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PhDArts
Research in and through art is an inseparable part of the artistic or design practice of the researcher. Consequently, research-in-art (as opposed to research-about-art, such as art history) does not have a set goal or expected result, nor are there predetermined general procedures. The outcome of the…
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Innovation centre for drug development on Bio Science Park
International pharmaceuticals company Grünenthal is to open an innovation hub on the Leiden Bio Science Park. The hub will make it easier for scientists and drug developers to work together.
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Applications of quantum annealing in combinatorial optimization
Quantum annealing belongs to a family of quantum optimization algorithms designed to solve combinatorial optimization problems using programmable quantum hardware. In this thesis, various methods are developed and tested to understand how to formulate combinatorial optimization problems for quantum…
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Algorithms for quantum software
Top scientists of three Dutch universities are working on software and systems for quantum computers. Researchers of the Leiden Institute of Advanced Computer Science (LIACS) and the Leiden Institute of Physics (LION) are developing new algorithms to make those super computers work. The coming years,…
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Design and evaluation of video portfolios: reliability, generalizability, and validity of an authentic performance assessment for teachers
The research study presented in this dissertation focuses on issues pertaining to the reliability, generalizability, and validity of authentic performance assessments of teachers.
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Mario van der Stelt
Science
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Roxanne Kieltyka
Science
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Gerard van Westen
Science
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Eline Dekeyster
Faculteit der Sociale Wetenschappen
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Madeline Kavanagh
Science
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Exploring Open-World Visual Understanding with Deep Learning
We are living in an information era where the amount of image and video data increases exponentially.
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NMR structural studies of protein-small molecule interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Walking as a Research Method in Art and Design
The Lectorate Design at the KABK explores the research method of walking from a design perspective, and features the working process used by public space and landscape designers Krijn Christiaansen and Cathelijne Montens (KCCM) who teach field research in BA Interior Architecture and Furniture Design…
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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The quest for new medicines against tuberculosis
Can drug screening for tuberculosis treatment be made more efficient?
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'Leiden' awarded for computational intelligence
The Leiden Institute of Advanced Computer Science congratulates alumnus Pepijn van Heiningen and the with the Technische Hochschule Köln shared PhD-student Samineh Bagheri. At the SSCI 2016 conference on computational intelligence in Athens last week, both of them won an award for the high quality of…
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Dirk Bouwmeester
Science
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Surendra Balraadjsing
Science
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Chemical Similarity: Structuring Risk and Hazard Assessment
At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.
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To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
PhD defence
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Hit Discovery
The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.
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New resource for the modelling community
The Repository from the Drug Disease Model Resources (DDMoRe) consortium provides a home to a collection of computational models of disease and drug action that have been used in pharmaceutical and/or academic research. This publically available open-access resource will make it easier for researchers…
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Leiden University hosts world championship computer chess
At the annual World Computer Chess Championship, chess computers from all over the world compete with each other. This year, Leiden University hosted the event.
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New in Leiden: Computer science and economics
In a survey held last year by the publication Elsevier, Leiden's Computer Science programme was voted by students as the best university programme of its kind in the Netherlands. And the Rotterdam Economics programme was voted the best in its field. Leiden University now offers a combined study based…
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Design Competition: Schouwburgstraat Community Garden
The Green Office wants to help start a community garden in the open patio space of the Schouwburgstraat buiding in the Hague.
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The power of one qubit in quantum simulation algorithms
Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…
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Arabic book design: slow progression
Since the end of the nineteenth century Arabic book designers have influenced the social and cultural situation in the Middle East with their work. Huda Smitshuijzen Abi-Farès has written the first global overview of this neglected field of science. PhD defence 10 January.
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laude physicist Tom O’Brien to research quantum chemistry by quantum computers
With defending his thesis ‘Applications of topology to Weyl semimetals and quantum computing’, the Leiden theoretical physicist Tom O'Brien has gained the rare 'cum laude' qualification. The freshly minted PhD has started a five year research programme on quantum algorithms for quantum chemistry, funded…
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Joni Reef
Faculteit Rechtsgeleerdheid
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The role of glomerular filtration and active tubular secretion in predicting renal clearance in children using population pharmacokinetic and
In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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Alumnus Robert Ietswaart: ‘Machine learning is revolutionising drug discovery’
Robert Ietswaart does research into gene regulation at the famous Harvard Medical School in Boston. He developed an algorithm to better predict whether a candidate medicine is going to produce side effects. He studied mathematics and physics in Leiden, and gained his PhD in computational biology in…
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Michael Lew explores how computers can see
Learning how computers can process and describe images just like human beings do. It is one of the key elements of the research of Michael Lew, who sees Deep Learning as a promising way to achieve this goal. On the 1st of January 2021, he was appointed Professor of Deep Learning at the Leiden Institute…
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History
Life Sciences Artificial Intelligence Data Science
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Spiking Neural P Systems
Promotor: J.N. Kok, Co-promotor: H.J. Hoogeboom
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University provides computer lessons for refugees
Computer skills are essential if you want to become part of Dutch society. Leiden University and Stichting Bestaanskracht, an organisation that helps the vulnerable, are therefore providing computer lessons for refugees who can use some extra digital help.
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Ecosia now available at Leiden University computers
LUGO has some news: If you are using a public computer from Leiden University, you can now set your default search engine to Ecosia.
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Fighting cancer with light (and a drug that self-assembles into nanoparticles)
Chemotherapy that does not harm the body, but effectively fights cancer cells: that is the goal of chemist Sylvestre Bonnet and his team. During his PhD research, chemist Xuequan Zhou brought that goal a little closer. He developed molecules that, upon injection in the bloodstream, self-assemble into…
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Evolutionary molecular dynamics
This thesis introduces the concept of
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Using AI to Combat Drug Resistance - an Interview with PhD student Rosan Kuin
Rosan Kuin started her PhD in July at the LACDR under supervision of prof. Gerard van Westen and Dr. Meindert Lamers. She completed a BSc. in Pharmaceutical Sciences at the VU University in Amsterdam in 2017. After that she started two master programs, Drug Discovery & Safety with a specialization in…
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University and Philips intensify collaboration for faster MRI with the aid of artificial intelligence
Together, Leiden University Medical Center (LUMC), Leiden University and Philips are one of the 17 AI labs within the ROBUST consortium that will receive support from the Dutch Research Council (NWO). The aim of this collaboration is to use artificial intelligence to speed up MRI scans.
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Using Conjoint Experiments to Study Preferences in Multidimensional Choice Contexts
This case study demonstrates how to design and effectively deploy a (survey embedded) conjoint experiment.
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LUMC involved in development of novel drugs to treat and prevent SARS-CoV-2 and other coronaviruses
The Department of Medical Microbiology at Leiden University Medical Center (LUMC) is researching antiviral drugs that could treat and prevent SARS-CoV-2 in various projects. One part of the PanCoroNed project is being led by Martijn van Hemert and involves lab tests into the antiviral effect of molecules…
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Ovalbumin coated pH-sensitive microneedle arrays effectively induce ovalbumin-specific antibody and T-cell responses in mice
The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…
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Annemarie Samuels
Faculteit der Sociale Wetenschappen
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Hilde van Meegdenburg
Faculteit der Sociale Wetenschappen
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LEELIS Conference on future of computer chips
A collaboration of physicists and chemists organized the LEELIS conference on new computer chip technology in Amsterdam on 10-11 November. Leiden physicist Joost Frenken is director of the organizing institute ARCNL.
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The hunt for the best computer language
Our language is adapted to the context in which we humans communicate. But computers ‘think’ differently. What would a language be like whose structure was optimally adjusted for use by humans and machines? Tessa Verhoef is trying to find the answer.