2,148 search results for “shared cell differentiatie” in the Public website
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Monica Arrigoni -
Bas GeerinckISSC
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Mark ThieleISSC
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Chris Müller
ISSC
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Henk LangeveldISSC
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Marcel Didden
ISSC
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Arnold SlootwegISSC
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Carel Fenijn
ISSC
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Environmental and genetic drivers of wood and lignin formation in flowering plants
In this project, we will study the genetic and environmental drivers of woodiness and stem lignification at the level of plant‐to‐gene‐to‐molecule.
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Fundamental and translational medical biochemistry
Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…
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Student experience
Lifelong learning | “Even though we were spread across five continents, there was a strong sense of connection.”
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Ferdinand TeichertFaculty of Science
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Max Fernkorn
Faculty of Science
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Cecile HerbermannFaculty of Science
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Ruben de VriesFaculty of Science
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Benjamin TakFaculty of Science
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Jingchao WuFaculty of Science
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Nina SchultenFaculty of Science
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Andreea Iosif
Faculty of Science
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Eliane ZügerFaculty of Science
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Daan VlemmingsFaculty of Science
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Yubin GuoFaculty of Science
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Christian SchröterFaculty of Science
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Yuting WangFaculty of Science
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Rafaella BuzatuFaculty of Science
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How public money for science leads to new medicines
Public funding for fundamental research is essential for innovation and the development of new medicines. This is demonstrated by Professor Science Based Business Simcha Jong and his colleague Hsini Huang after studying US federal funding restrictions for stem cell research under President George W.…
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Combatting infectious diseases; nanotechnology as a platform for rational vaccine design
Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.
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Curing diseases with lab-grown organs
Organs and tissues grown in the lab may in the future be able to cure people with organ failures. Micha Drukker, professor of Stem Cells, Developmental Biology and Technology for Innovative Drug Research, is convinced that the use of stem cells will make this possible. He will deliver his inaugural…
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Covalent inhibitors of G protein-coupled receptors: the case of adenosine receptors
Supervisor: Xue Yang
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Leiden Academic Centre for Drug Research
The Leiden Academic Centre for Drug Research (LACDR) is a centre of excellence for multidisciplinary research on drug discovery and development.
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Pursuing new anti-cancer therapy as a team
Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…
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Kinetics for Drug Discovery: a Case for the Adenosine A3 receptor
Supervisor: Lizi Xia
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Macromolecular Biochemistry
Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Lars Jeuken, Anne Wentink, Sebastian Geibel, Anjali Pandit, René Olsthoorn, Alia, and Steffen Brünle.
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The versatility of asymmetric aminoethyl-tetrazines in bioorthogonal chemistry
This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.
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Research in Physics, Biological and Soft Matter Physics (MSc)
The Physics and Biological and Soft Matter master's specialisation is one of the two programmes that Leiden University offers in experimental physics. This programme mainly focuses on Biological Physics and Soft Matters Physics.
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Christoph Niessen
Faculty of Social and Behavioural Sciences
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Horizon2020 grant for toxicologist Bob van de Water
An international research consortium led by Bob van de Water, Professor of Toxicology at Leiden University, has been awarded a prestigious Horizon2020 grant of 30 million euros.
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Determining the kinetic profile of ENT1 inhibitors
Supervisor: Anna Vlachodimou
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Research
The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Cell Systems and Drug Safety, Medicinal Chemistry and Systems Pharmacology and Pharmacy, and the Metabolomics and Analytics Centre.
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Research
At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.
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Dame Lab / Chromatin Organization & Dynamics
Throughout all domains of life, from bacteria and archaea to eukaryotes, genomes adopt well-organized three-dimensional structures that can change in space and time to accommodate preferred transcriptional programs for environmental adaptation, the maintenance of cellular identity and differentiation…
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Polar auxin transport: translating environmental signals into plant developmental responses
1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…
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Leiden Science Young Talent Award
The Leiden Science Young Talent Award is awarded yearly to a student who completed their bachelor’s degree with an excellent thesis.
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Host-Microbe Interactions
Microbes influence and respond to other organisms. This theme explores the dynamic relationships within plant and animal microbiomes, and the immune responses that govern host defense. Using model systems such as zebrafish, insects, and plants, we investigate fundamental processes and engineer microbes…
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Better understanding of cancer drugs – Leiden spin-off Omivera receives seed investment
How do you know if a drug will actually work? The Leiden-based spin-off Omivera is developing a new technology that could provide clearer answers. The young company received a seed investment from the investment fund UNIIQ to support its development.
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Plant ageing, rejuvenation and life history strategy
What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?
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LED3 Drug Discovery Case Studies
To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.
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Research
PBDL favors multidisciplinary research. Depending on the problems under investigation, PBDL establishes collaborations between experts from for example molecular genetics, molecular and electro cell physiology, biochemistry, organic chemistry, analytical mathematics, mathematical statistics and computational…
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Expertise
The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…
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High throughput microscopy for cellular adaptive stress response pathways in drug adversity
High throughput microscopy