This edited volume suggests promising new avenues of research in analyzing coalition politics. Written by a group of leading scholars, the book clarifies a number of concepts too often taken for granted in the existing literature, performs theoretically-driven and methodologically novel comparative…

Promotor: Prof.dr. E.F. Smets, Co-promotores: Dr. B. Gravendeel, F. Pupulin

On the 12th of December, Eleanor Dutton successfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Eleanor on this achievement.

This dissertation investigates A'-dependencies in Standard German, Zurich German and Dutch where the dislocated constituent is indirectly, i.e. not transformationally, related to the position where it is interpreted. The analysis is carried out within the Principles & Parameters framework.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

The Centre for the Study of Political Parties and Representation (CSPPR) aims to serve as an interdisciplinary platform for scholars of Leiden University for research focusing on the historical and contemporary operation and functioning of political parties and political representation, with a particular…

From 1 August 2018, Alanna O'Malley was appointed as Chair of United Nations Studies in Peace and Justice, focusing on the ‘lesser-known actors’ of the UN: women, the youth, the agents of informal diplomatic networks within the UN and actors from the Global South. This Special Chair has been created…

This case study demonstrates how to design and effectively deploy a (survey embedded) conjoint experiment.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

In specialist organ literature a negative verdict is given on organs and organ specialists from the 1930’s. Did the same verdict apply to Johan van Meurs’ (1903-1986) work? Which role does Van Meurs’ collection of organ specifications play in the historical research on the organ?

Promotores: F.H.J. Redig, W.T.F. den Hollander

The Department of Child Law collaborated on a study on missing children in the European Union for the European Commission. The outcomes of the study aim to help to improve the mechanisms involved when children are missing in EU Member States.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

This project investigates the globalization and cultural mediation of palliative care practices, policies and discourses.

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

In this thesis, the research focuses on the properties of dark matter and dark matter haloes and how they connect with the galaxies we can observe in the Universe.

On the 12th of November, Xander Vertegaal successfully defended a doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Xander on this achievement!

This research cluster explores processes of cultural creation, reception and transformation within a wide range of societal contexts from the early Middle Ages until c. 1800.

What is the cost of visual complexity? This dissertation sets out to determine the effect of the complexity of word formation on the legibility of Arabic and the role that vocalization plays in reading.

This thesis attempts to establish a dialogue between the modern and the medieval traditions in logic, by means of ‘translations’ of the medieval logical theories into the modern framework of symbolic logic, i.e. formalizations.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

This article presents two related arguments. First, the limits of doctrinal analysis cut deeper than many EU lawyers realise. Most would probably accept that legal doctrine does not determine every legal dispute, but lawyers studying EU institutional balance often still assume that it can be deduced…

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Political scientist Wouter Veenendaal (Leiden University) provides an in-depth case study of clientelism in Malta, the smallest member state of the European Union. He reveals that not only that patron–client linkages are a ubiquitous feature of political life in Malta, but also that the smallness of…

Combined hormonal contraceptives (CHC) are associated with an increased risk of venous thromboembolism (VTE). In 2013, a review was published by the European Medicines Agency (EMA). In this review, the authors concluded that the risk of VTE varies by the type of progesterone in the CHC. Subsequently,…

The Organ Art of the first female German concert organist and Bremen Cathedral organist and

Promotor: Prof.dr. G.P. van Wezel

Promotor: M. Ubbink, Co-promotor: G. Siegal

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

The adsorption of D2 and CO2 on catalyst surfaces is studied using a molecular beam in ultra-high vacuum.

The electrochemical hydrogenation reaction is an alternative approach for the transformation of unsaturated bonds without the use of flammable dihydrogen gas.

On Friday 15 November 2024 Chunli Song successfully defended a doctoral thesis and graduated.

The ARTIVES project studies imaginaries of diversity portrayed by artists in Lisbon and Rotterdam in their films, performances and (oral) literature with the aim to explore their transgressive potential of opening up possibilities of thinking differently about migration-related diversity. Their stories…

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

What is the impact of research-based learning on critical thinking competence and academic achievement in undergraduate education? What are underlying factors of research-based learning in the learning environment?

What is the optimal way to utilise intermediate assessment in improving study behaviour and study success?