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• Getting personal: Advancing personalized oncology through computational analysis of membrane proteins Research output

  Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

• Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies Research output

  Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

• Collaborations Ecotox

  Ecotox is located in an ambitious surrounding at the Leiden University. It is an initiative of both institutes Institute of Environmental Sciences (CML) and Institute of Biology Leiden (IBL).

• Unraveling the auxin mechanism in 2,4-D induced somatic embryogenesis in Arabidopsis thaliana Research output

  Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

• The role of the Arabidopsis AHL15/REJUVENATOR gene in developmental phase transitions Research output

  This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

• Towards a mechanistic understanding of nanoparticle behavior using zebrafish Research output

  The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

• Synthesis of chemical tools to study the immune system Research output

  This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

• Vaccine delivery Research project

  Vaccination via the skin or the mucosae

• In vitro and in vivo delivery of functionalized nanoparticles via coiled-coil interactions Research output

  Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn