Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Promotor: Prof.dr. G.J. Kroes

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

This project aims at determining the market value of hydrogen peroxide (HP) that is produced via our electrochemical methods that have been developed as part of the ERC-StG Cu4Energy project.

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

Promotor: Prof.dr. J.P. Abrahams

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

Promotor: M. Ubbink, Co-promotor: G. Siegal

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

Assistant Professor at the Department of Analytical Chemistry, Radboud University Nijmegen, the Netherlands

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

Hydrogen peroxide (H2O2) generation via electrochemical oxygen reduction is a sustainable production method for this bulk chemical. However, the selectivity of molecular catalysts for electrochemical H2O2 generation has hardly been investigated in a systematic manner, and it is unknown if their stability…

Promotor: Prof.dr. M. Ubbink

We report new computational and experimental evidence of an efficient and astrochemically relevant formation route to formaldehyde (H2CO). This simplest carbonylic compound is central to the formation of complex organics in cold interstellar clouds and is generally regarded to be formed by the hydrogenation…

Career and apply for jobs

As a venue, Leiden University is a fitting setting for recognising the outstanding achievements of the award winners and celebrating the inspiration that they bring as role models for encouraging a fairer society by motivating one individual at a time.

This is an Erasmus+ International Credit Mobility project of the Faculty of Science with the Taras Shevchenko National University of Kyiv.

Did he dare take a gamble with his PhD research? Jeroen Methorst didn’t have to think long about it. It could fail or turn out very well. The latter is the case. Methorst developed a computer system that helps researchers find the protein they need. ‘Our whole group is now using this program.’ Methorst…

Lecture

Conference

Twenty years from now, the world population is estimated to be around 9 billion people (now 8 billion). In combination with the improvements in living standards and the corresponding growth in consumption, this population will result in an enormous increase in the demand for food, consumables, water…

Some examples of AI-research done at Leiden.

Which teacher did an outstanding job in not only transferring knowledge in novel ways but also in getting students enthusiastic and connecting a course to current research themes? Meet the nominees for the Teacher of the Year Award 2024!

How do pathogenic mycobacteria alter lipid metabolism in human cells and patients, and which disrupted pathways could be targeted for new antibiotics?

Meet the scientists within the LED3 community

Are you the scientist of the future? Come experiment with science at the Experiments Square! Make your own slime, discover how rubber can count, play along with the antibiotics game, discover the power of light and much more!

The confinement of molecular catalysts in metal-organic frameworks has the potential to lead to significant improvements in selectivity, long term activity and catalyst stability.

Lecture

Developing safer alternatives to harmful PFAS filters and seeking new enzymes for medical applications. Two projects with Leiden researchers have been awarded funding through the Dutch Research Council's (NWO) Open Technology programme.

Are you interested in taking up an extra challenge during your master’s programme?

In 2024, many of our students and staff won great prizes and secured important research grants.

Many researchers of the Faculty of Science are members of a research school related to their area of expertise. Research schools aim at collaboration of researchers from different faculties in the same university (interfaculty schools) or in different universities (interuniversity schools).