This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

The Physics and Biological and Soft Matter master's specialisation is one of the two programmes that Leiden University offers in experimental physics. This programme mainly focuses on Biological Physics and Soft Matters Physics.

An international research consortium led by Bob van de Water, Professor of Toxicology at Leiden University, has been awarded a prestigious Horizon2020 grant of 30 million euros.

Supervisor: Anna Vlachodimou

The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Cell Systems and Drug Safety, Medicinal Chemistry and Systems Pharmacology and Pharmacy, and the Metabolomics and Analytics Centre.

The Leiden Science Young Talent Award is awarded yearly to a student who completed their bachelor’s degree with an excellent thesis.

How do you know if a drug will actually work? The Leiden-based spin-off Omivera is developing a new technology that could provide clearer answers. The young company received a seed investment from the investment fund UNIIQ to support its development.

Microbes influence and respond to other organisms. This theme explores the dynamic relationships within plant and animal microbiomes, and the immune responses that govern host defense. Using model systems such as zebrafish, insects, and plants, we investigate fundamental processes and engineer microbes…

What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

PBDL favors multidisciplinary research. Depending on the problems under investigation, PBDL establishes collaborations between experts from for example molecular genetics, molecular and electro cell physiology, biochemistry, organic chemistry, analytical mathematics, mathematical statistics and computational…

The research that is united in the Liveable Planet programme, touches upon a wide range of aspects of human life. The goal is to deepen and expand the scope and to connect more researchers. The following case studies are examples of current research projects.

This research examines the social, political, and cultural forces that structure people’s responses towards accented speech, and further uses the accent as a focal point to theorize the interrelation between language and body.

Madeleine O. Hosli & Jaroslaw Kantorowicz analyze EU states' foreign policy divergence at the UN General Debate, assessing if Lisbon Treaty reforms increased EU cohesion or if states maintain distinct positions.

On 21 September 2022 Arfiansyah successfully defended a doctoral thesis and graduated.

The unique geographic and temporal breadth of research at Leiden allows us to stimulate a shift from the classical Weberian mode of scholarly production that views historical development and modernization as emanating from Europe and the West to a multi-polar perspective that allows for more nuanced,…

The master's specialisation Applied Mathematics at Leiden University focuses on both computational and fundamental aspects of analysis and probability. It’s also an ideal basis for a PhD degree. Applied Mathematics is an excellent choice if you have the aspiration to pursue a PhD degree

This study focuses on the local level impacts of a highly globalised industry: the international trade in tropical timber.

This article offers an inaugural assessment of how silences implicate international law-making in cyberspace through descriptive and normative lenses.

Can we identify different degrees of economic integration, both within and between regions, on the basis of archaeological proxies?

How do different emotional expressions influence the behavior of other people in negotiations?

In this article, Dimiter Toshkov investigates the determinants of COVID-19 vaccine hesitancy and refusal, focusing on Eastern, Southern and Western Europe.

The data-driven economy allows for the collection and processing of large amounts of data. Such data can be used to optimize profits by (dynamically) differentiating prices for different consumers.

Investigating specific language and speech behaviour of people.

Although plant domestication has significantly altered crop genetics and phenotypes, its effects on the taxonomic and functional diversity of plant-associated microbiomes are not well understood.

This project will study the influence of Arabic, Iberian, and Italian representations of Africa, as well as the impact of local African knowledge, on Dutch imaginations which were public in nature, and thus affected a shared European understanding of African alterity.

On the 2nd of September Jiyan Qiao successfully defended a doctoral thesis and graduated.

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…

High throughput microscopy

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

X-Ray Diffraction (XRD), Nuclear Magnetic Resonance (NMR) and Cryo-electron microscopy (Cryo-EM) are the three main methods for solving structures of macromolecules.

Promotor: Prof.dr. W. Jiskoot, Co-promotor: A. Kros

The Therapeutic Immunomodulation Group is led by Prof. Johan Kuiper. In this group we aim to identify novel immunologic targets and apply immunotherapy to inhibit or even prevent the development of atherosclerosis.

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

The LUMC iPSC Hotel offers the generation of research grade human induced pluripotent stem cells (hiPSCs) from different tissue sources using state of the art reprogramming techniques.

The Aging and Immunity group is led by Dr. Amanda Foks. In this group we aim to investigate how aged immune cells contribute to atherosclerosis and identify novel therapeutic targets and strategies to extend health span and inhibit cardiovascular disease.

Agrobacterium-mediated transformation (AMT) has abundantly been used for scientific research for identifying valuable traits.

We are interested in understanding the mechanics of soft materials, of which biological materials are prominent examples.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Source: Mol Psychiatry (2015)

The Leiden Institute of Chemistry (LIC) is the basis for research and collaborations of the Leiden chemistry groups. Chemistry is the central science enabling a healthy future in a sustainable society. Chemistry researchers at Leiden University take a fundamental approach in finding tailored solutions…

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Key publications of the Aging and Immunity group

MT3 is a globally unique programme led by professors and expert authors that covers the most up-to-date knowledge possible in the area of Classical Transfusion Medicine and Cellular and Tissue Therapy. It provides access to high quality knowledge and skills via a completely online system.

The Division of BioTherapeutics at the Leiden Academic Centre for Drug Research (LACDR) is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?