The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

Promotor: G. J. Kroes

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

Nonadiabatic energy transfer from the translational motion (T) of a molecule impinging on metal surface to the metal’s electrons may determine whether the molecule can lose enough energy to adsorb or react.

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.

This thesis comprises the development of reproducible synthesis procedures for two-dimensional materials (composed of boron, nitrogen and carbon) on different metallic surfaces.

Many of the journal's issues contain short contributions from practitioners of diplomacy. These practitioners' essays offer unique insights into the world of diplomacy and they serve as a source of inspiration for researchers.

Explore the programme structure of the MSc The Politics of Artificial Intelligence at Leiden University: core courses, elective seminars, internship option, thesis research and real-world AI governance cases.

Collaborators and advisors of the Plant BioDynamics Laboratory

Design and synthesis of two 3-substituted swainsonine derivatives with the aim to improve the potency and selectivity towards Golgi alpha-mannosidase II.

Hass

Synthetic methodlogy is described, aiding in the synthetic preparation of putative inhibitors of retaining and inverting glycosidases and glycosyl transferases. All constructs are cyclophellitol-based cyclitols.

The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

Corruption, integrity (or a lack thereof…) and public values are near omnipresent elements in public administration and politics of all times. Cases of corrupt public officials and politicians continuously emerge. Strangely enough, however, it often remains unknown what actually occurred, how something…

Three Humanities lecturers received the Senior Qualification in Education (SKO) this year. University lecturer Bruno Verbeek is one of them. What does he think makes for good education?

In 2025 hebben medewerkers en studenten van de Universiteit Leiden veel mooie prijzen ontvangen en belangrijke onderzoekssubsidies binnengehaald.

At Leiden Observatory, researchers investigate the origin of stars and their planetary systems. They detect and characterize planets around other stars, which are called exo-planets. They study how stars and planets form. And they follow molecules from interstellar clouds to nascent planet systems.…

Former PhD student Cameron Mackie will been awarded not one, but two dissertation prizes for his thesis on the aromatic universe. His work could provide us with a virtual sniff of space. ‘These molecules in space likely smell like a big charcoal grill!’

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

The

On October 23rd, dr. Bart Custers, associate professor and head of research of eLaw, the Center for Law and Digital Technologies at Leiden Universitty, delivers a keynote address on the big data and law at the International Conference on Big Data Research (ICBDR 2017) in Osaka, Japan

Contact Macromolecular Biochemistry

Conact the Cellular Chemistry group

Find out how to apply for Chemistry at Leiden University by following our step-by-step guide.

Requirements for admission to the Graduate School and the steps described below in short are described in detail in the Leiden University PhD Regulations.

The Executive Board and the Board of Education of the Institute of Psychology are responsible for the organisation. A number of committees offer specialised knowlegde, such as the Research Ethics Committee. Students have a say in programme committees.

The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…

Chronic pain, nausea or vomiting due to chemotherapy. If you suffer from such ailments, medicinal cannabis can be a godsend. Though a downside is that it can make patients high. Therefore, Leiden researchers from the Oncode Institute are investigating alternatives that do not make you high. In Nature…

In this project of the Center for Public Values & Ethics (CPVE) ongoing research is conducted on the history of advice to Dutch central government by so-called State committees from 1814 to 2014. State committees have been installed by Dutch central government since 1814 to provide expert advice, research…

Embedding ethical legal and societal aspects for responsible military AI.

Responsible AI for science and a strong and resilient society.

Can small molecule drugs restore the immune system’s ability to fight tuberculosis by boosting autophagy?

Discover all the Leiden Science teaching talent that was part of this year's lineup.

Sustainable energy from wind and solar is most readily available near the sea.

Humanity stands at a pivotal juncture, facing the dual challenge of environmental sustainability and rapid population growth, projected to exceed 11 billion by century’s end.