Leiden University is an international, broad-based university. We distinguish five core domains for our research and teaching activities.

The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.

Understanding individual differences in self-regulation in boys with ODD/CD on the level of brain, cognition and behavior

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

PURPOSE: In the present study we investigated the root-cause of an interference signal (100-200 nm) of sugar-containing solutions in dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) and its consequences for the analysis of particles in biopharmaceutical drug products.

In 2008, the intervention ‘Denken + Doen = Durven’ (Think + Do = Dare) was developed in the Netherlands (Bögels, 2008). This is a cognitive behavioral therapy program for children and young people between the age of 8 to 18, diagnosed with an anxiety disorder. The intervention is given by a professional,…

Zhaole Yang defended his thesis on 25 June 2020.

Promotor: Prof.dr. L.J. Slikkerveer

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Provides a cutting-edge comparative political economy analysis of welfare and inequality across ten East Asian countries.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

This dissertation shows that dialogical logic constitutes a powerful and flexible general framework for the development and study of various logical formalisms and combinations thereof.

The unit Health, Medical and Neuropsychology offers eduction and conducts research on related fields of Health, Medical and Neuropsychology.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

From basic science to real-world interventions

In his book The magic of healing, Willem van der Does talks about 14 pioneers in the history of psychiatry. These pioneers all had one thing in common: they started with a radical idea which led to great enthusiasm.

Heart failure is a major health care problem with high mortality.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Promotor: Prof.dr. R. Verpoorte, Co-promotores: Dr. Y.H.Choi, N.R. Mustafa

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

On 14 November, Ilya Kokorin defended the thesis 'Intra-group financing and enterprise group insolvency: problems, principles and solutions'. The doctoral research was supervised by Matthias Haentjens and Reinout Vriesendorp.

On 9 November, Roosmarijn van Es defended the thesis 'The mind in the courtroom: on forensic mental health reports in judicial decision-making about guilt and sentencing in the Netherlands. The doctoral research was supervised by Jan de Keijser, Maarten Kunst and Janne van Doorn.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

On the 23rd of March, Alessandro del Tomba successfully defended a doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Alessandro on this achievement!

How can we implement the technique of pharmacological resting-state fMRI to improve the diagnosis of dementia?

This dissertation provides an up to date description of the Indo European lexical stock of Armenian (ca. 500 entries) with systematic inclusion of unused data that are found in Armenian dialects.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

On 1 February 2018 Nathalie-Sharon Koster defended her doctoral thesis ‘Crime victims and the police’. The doctoral research was supervised by Professor J.P. van der Leun and M.J.J. Kunst.

From descriptive to physiological models that can predict oral absorption and elimination of CYP3A substrates across the pediatric age range.

Mental health issues in the Dutch court: The criminal court as a border guard between the regular Mental Health System and the Criminal Justice system?

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

On 21 February 2019, Ruben Zandvliet defended his thesis 'Trade, Investment and Labour: Interactions in International Law'. The doctoral research was supervised by Prof. dr. N.J. Schrijver.

Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

Artificial intelligence could help make the work of public sector organisations, professionals, policy- and decision makers more effective, more efficient, and ideally could make it more rationalised and evidence-based.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

Nietzsche has often been considered a thinker independent of the philosophy of his time and radically opposed to the concerns and concepts of modern and contemporary philosophy. But there is an increasing awareness of his sophisticated engagements with his contemporaries and of his philosophy's rich…

On Tuesday 17 October 2017 Alexandre Genest defended his PhD dissertation ‘Performance Requirement Prohibitions in International Investment Law’ as part of a double PhD programme at the Universities of Leiden and Ottawa. The Supervisors are Professors M.E. Koppenol-Laforce. F. Baetens (Universities…

Hospital pharmacies face significant challenges: the demand for sterile drug reconstitutions is increasing, while specialized personnel remain scarce. Automation offers a potential solution, but its practical implementation in hospitals is still unclear.

Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

The Next444 project focuses on the future of interdisciplinary research at Leiden University.