The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

Assistant Professor at the Department of Analytical Chemistry, Radboud University Nijmegen, the Netherlands

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

Hydrogen peroxide (H2O2) generation via electrochemical oxygen reduction is a sustainable production method for this bulk chemical. However, the selectivity of molecular catalysts for electrochemical H2O2 generation has hardly been investigated in a systematic manner, and it is unknown if their stability…

Promotor: Prof.dr. M. Ubbink

We report new computational and experimental evidence of an efficient and astrochemically relevant formation route to formaldehyde (H2CO). This simplest carbonylic compound is central to the formation of complex organics in cold interstellar clouds and is generally regarded to be formed by the hydrogenation…

Hydrogen peroxide (H2O2) is an important bulk chemical that is used in various industrial processes. More than 95% of the H2O2 used in industry is made via the anthraquinone process during which a large amount of energy is going to waste.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

This perspective addresses four challenges facing theorists whose aim is to make quantitatively accurate predictions for reactions of molecules on metal surfaces, and suggests ways of meeting these challenges, focusing on dissociative chemisorption reactions of H2, N2, and CH4.

Pancreatic ductal adenocarcinoma (PDAC) is the deadliest common cancer, with only 8% of patients surviving for five years. One reason for this poor outcome is that current chemotherapy treatments are highly toxic, often leaving patients too sick to receive treatment or forcing doctors to lower the dose…

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Promotor: Prof.dr. G.J. Kroes

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

OSCL members, amongst which our representative in the Archaeology faculty, were part of Data Carpentry for Social Sciences. Here's what happened.

Up to 50% of all children and adolescents growing up worldwide are exposed to at least one form of childhood adversity (CA), which is one of the strongest predictors for later-life psychopathology.

UnMiSSeD studies the interaction between misinformation and science in societal debates using a mixed qualitative-quantitative approach.

Jelle van Buuren, university lecturer at ISGA, discusses the role that social media played in the storming of the Capitol last Wednesday

Our researcher and PhD candidate Helena Ursic was interviewed with Druzina, one of the biggest weekly newspapers in Slovenia.

As part of Nexus 1492 Subproject 4: A Future for Diverse Caribbean Heritages, which seeks to shed light on how local communities interpret and engage with heritage in the present day, this doctoral study aims to gain insight into how indigenous heritage is represented in the school curriculum for social…

Jifeng Liu defended his thesis on 2 February 2017

The main question I want to answer is about the mutual influence between the cultural and settlements changes that occurred between the Bronze and the Early Iron Age in Margiana and the management of water resources.

With the emergence of online social networks (OSNs), the way people create and share information has changed, which becomes faster and broader than traditional social media.

Wenxin Wang defended her thesis on 26 October 2016

Alumni event

From a successful April Fool’s prank and alumni love stories to a fabulous float on 3 Octobe: these were the highlights of our year on our social media channels. Hope you’re following us?

Receiving positive support and seeing yourself as being a quitter may help smokers quit, say Eline Meijer and colleagues. The health psychologists published their study in Social Science & Medicine.

Why are not all children equally responsive to variations in the social environment?

Investigating neurobiological endophenotypes of Social Anxiety Disorder