Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

Currently, Navigation Lab Leiden works on three main themes: navigation ability, spatial abilities, novel techniques in neuropsychology.

On May 31st, Bobby Ruijgrok succesfully defended his doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Bobby on this great result.

Understanding individual differences in self-regulation in boys with ODD/CD on the level of brain, cognition and behavior

Central elements in the research activities of all programme group members are: attachment, sensitive caregiving, and prevention and intervention.

Science begets technology but technology also begets science. Anne Urai from the Leiden Institute of Psychology is part of an international team team that rolls out a new, user-friendly, plug-and-play AI tool they hope will become an engine of discovery by quantifying the growing volume of recorded…

The project ‘Food citizens? Collective food procurement in European cities: solidarity and diversity, skills and scale’ has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 724151).

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Imitation is, perhaps more than ever, constitutive of human originality.

People who have taken antibiotics in the past three months pay more attention to negative facial expressions, according to research by postdoc Katerina Johnson and assistant professor Laura Steenbergen. This may explain how antibiotics increase the risk of developing depression.

Vocal learning is a trait shared by songbirds and humans. It is also a trait that is restricted by the brain rather than by a species' vocal apparatus. In this dissertation, functional MRI is employed in both species in order to explore potential common neural mechanisms underlying the ability to develop…

Are you graduating at the Faculty of Science? Or are you supervising a PhD student? At the Graduate School of Science you find support at every phase of your PhD.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

The Cognitive Psychology Unit is organized as follows:

Mapping the neural mechanisms underlying social motivations of adolescents and adults

Developmental and Educational psychology is concerned with the developmental course and dynamics of cognition, self-regulation, and emotional competence, and the implications for educational and clinical practice.

The aim of the RAISE study is to investigate how resilient people respond to stress. Specifically, we will study how key biological systems (HPA-axis, immune system) interact with the brain and social environment in order to facilitate resilient functioning after childhood adversities.

Measurement of brain activity by external electrodes (EEG).

Design of a Linguistic System for Interstellar Communication Based on Logic

Leiden University seeks to bring knowledge, academic top talents, and resources from Leiden and Latin America and the Caribbean together in mutually beneficial joint research projects that are content-driven, based on existing excellent research. Connecting research and researchers.

Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

Psychology Lab on Wheels makes research accessible to all: with our mobile lab we literally reach people on the street. From bustling city centres to remote areas, our lab travels all over, making it easy for you to participate in our research. And with your help, we gain new insights and deepen our…

Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…

How do cognitive, motivational, and affective processes interact to select actions?

How do humans control their thoughts and actions, and what can high-field brain scanning reveal about the underlying processes?

How do different emotional expressions influence the behavior of other people in negotiations?

The Chemical Biology & Immunology (CBI) group is headed by Prof. Sander van Kasteren and Prof. Kim Bonger.

Taal als sleutel tot het begrijpen van de mens.

The Public Prosecution Service in the Netherlands is examining the possibility to prosecute Dutch national Jitse Akse on the suspicion of the multiple murder of Islamic State fighters. As a foreign fighter Akse joined the Kurdish militia YPG in its armed struggle against the Islamic State.

The Sustainable Development Goals (SDGs) should have ended poverty, inequality and climate change by 2030. In a special campaign, the Dutch universities are showing how they are helping to achieve these goals.

The Dutch Constitution is the second oldest constitution in the world after the US Constitution and it dates back to 1814. Wim Voermans, Professor of Constitutional and Administrative Law and author of the book ‘Our Constitution’ published earlier this year, advocates for a more accessible Constitut…

Can judges be impartial if they are a member of a political party? In PowNed podcast ‘Op z'n Kop!’, Andreas Kinneging, Professor of Philosophy of Law, questions what he sees as an outdated system.

Can humans perceive single photons? What is our place in the universe? How can we make quantum computers more stable? Five researchers from the Faculty of Science have received funding for their research projects within the Dutch Research Agenda (NWA).

eLaw in collaboration with the TU Delft Design for Values Institute finalized the research on “Artificial Intelligence and Ethics at the Dutch Police” by providing the whitepaper highlighting requirements for the responsible use of AI at the Police and the long-term research strategy.

Staff shortages within the Dutch police force mean that fewer reported crimes are being investigated. Maarten Kunst, Professor of Criminology, spoke to Dutch public broadcaster NOS about the consequences of the staffing problems.

After the fall of the Dutch cabinet, the Party for Freedom (PVV) ministers have resigned. They are now entitled to redundancy pay. Barend Barentsen, Professor of Labour Law, answered questions on the topic in the NPO podcast ‘Alledaagse Vragen’.

Researchers from Leiden and Groningen have found a fossilised paw of one of the last Dutch brown bears. They made their discovery in the water supply system in the dunes near to Noordwijk.

Advanced microscopy to understand life and fight disease: that’s the goal of the new NL-BioImaging network that will develop and integrate state-of-the-art microscopy technologies and services. Researchers from all Dutch universities, including Leiden University and the Leiden University Medical Centre,…

By working together with external social partners, the knowledge of our scientists finds its way into society.

The representation of death children in Dutch literature through time

There is an ongoing struggle between the Minister of Public Health, Hugo de Jonge, and the Dutch Municipal Health Services (GGDs). De Jonge wants the GGDs to speed up testing, conduct more tests, and allow priority testing but the GGDs are pulling on the brakes. The waiting lists for a corona test have…

Are you interested in expanding your knowledge on the Dutch crisis management system? Leiden University is organising a unique lecture series on the subject in collaboration with the Netherlands Institute for Public Safety (NIPV). The lectures will take place on 22 April, 13 May, and 3 June.

How do you deal with bullying? How can you motivate young people? At the NeurolabNL symposium a multidisciplinary research team launched an interactive book for teachers and youth workers. This digital book offers the latest insights and plenty of useful tips and advice. Children’s Ombudsman Margrite…

Astronomy departments at Dutch universities is among the top of the world rankings for astronomical institutions. This is the conclusion drawn from a recent evaluation of the Netherlands Research School for Astronomy (NOVA) and the astronomy institutions of the University of Amsterdam, the University…

The Dutch X-omics Initiative has received seventeen million euros from NWO as part of the National Roadmap for Large-Scale Infrastructure. Leiden University’s metabolomics research led by Thomas Hankemeier is one of the participators.

Leiden University occupies the 95th place in the QS World University Ranking, making it the fourth Dutch university in the Ranking. In 2014 Leiden was in 75th position. However, a radical new measuring method makes comparison with previous years problematic.

Rogier Kegge, Assistant Professor in administrative law and environmental law, is a member of the Dutch Health Council’s Committee on Livestock Farming and Health. The Committee recently published a report on links between goat farms and pneumonia.

On Thursday 28 September, the Committee on Social Minimum, of which Koen Caminada is a member, presented its second report to outgoing minister for poverty policy in the Netherlands, Carola Schouten. The Committee was established by the minister at the request of the House of Representatives.