1,661 search results for “shared cell differentiatie” in the Public website
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Elsa NeubertFaculty of Science
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Andraniek EvadgianFaculty of Science
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Daisy BatenburgFaculty of Science
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Kim ElbertseFaculty of Science
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Maayke van RulerFaculty of Science
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Inge SnijdersFaculty of Science
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Herman van VlijmenFaculty of Science
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Programme
On this page the programme and sessions can be found.
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John van Noort Lab - Chromatin Dynamics
Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.
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Harnessing zebrafish xenograft models for ocular melanoma treatment discovery
The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…
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The synthesis of mannose-derived bioconjugates and enzyme inhibitors
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee
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Application of zebrafish and murine models in lipoprotein metabolism and atherosclerosis research
Cardiovascular diseases are still a major concern for the global health.
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Responding to environmental cues: the adaptive qualities of chromatin compaction proteins
Promotor: M. Ubbink, Co-Promotor: R. T. Dame
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Our approach
Our group operates at the cross-roads of different disciplines: molecular and cellular microbiology, biochemistry, structural biology and biophysics. The group harbors expertise in a multitude of molecular and cellular approaches including:
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Spin-label EPR Approaches to Protein Interactions
Promotor: Prof.dr. E.J.J. Groenen
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Vascular and Regenerative medicine
With an ageing population it is becoming increasingly important to find means to repair cells, tissue and organs through regenerative medicine.
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Publications
A selection of recent publications from the Plant BioDynamics Laboratory.
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Two-photon multifocal microscopy for in vivo single-molecule and single-particle imaging
In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.
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Peptide amphiphiles and their use in supramolecular chemistry
Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros
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Henkes Group - Active Materials
The research group of Silke Henkes at Leiden University. Part of the Leiden Institute of Physics (LION). The group studies the physics opf active materials.
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Bioorthogonal Antigens
The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.
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Unravelling cancer drug resistance mechanisms
Mechanisms fro drug resistance
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Activity-based protein profiling of diacylglycerol lipases
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Helmut Schiessel Group - Theoretical Physics of Life Processes
The group Theoretical Physics of Life Processes, led by Helmut Schiessel, focuses on the physics of chromatin, the DNA-protein complex that fills the nuclei of eukaryotic cells.
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Copper complexes for bioinspired electrocatalysis relevant to the reduction of oxygen
This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.
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'Q-wires': Synthesis, electrochemical properties and their application in electro-enzymology
An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.
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Design and Synthesis of Inhibitors and Probes for Sulfoquinovosidases and Xylanases
This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.
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Identification of novel targets in prostate cancer progression
Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen
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Inverse electron demand Diels-Alder pyridazine elimination: synthetic tools for chemical immunology
The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…
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Jeroen Jansen
Assistant Professor at the Department of Analytical Chemistry, Radboud University Nijmegen, the Netherlands
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The role of autophagy during carbon starvation in Aspergillus niger
Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.
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Agonists for the Adenosine A1 Receptor with Tunable Residence Time. A Case for Nonribose 4-Amino-6-aryl-5-cyano-2-thiopyrimidines
Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)
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Research
SBB research focuses on the complex operational, organisational dynamics of technology-intensive sectors.
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Transforming data into knowledge for intelligent decision-making in early drug discovery
Promotor: A.P.IJzerman Co-promotor: A. Bender
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MYC transcription factors: masters in the regulation of jasmonate biosynthesis in Arabidopsis thaliana
Promotor: J.M. Memelink
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Summer School: Frontiers of Modern Physics
This is the physics summer school of Leiden University. It is part of the Leiden Institute of Physics (LION). The summer school is intended for Bachelor (BSc) students in physics. It covers topics from quantum matter and optics, to biological & soft matter physics and cosmology and theoretical physics.…
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Biological, Soft and Complex Systems
The research groups within the biological, soft and complex systems research area study the physics of a broad range of biological and soft materials. This spans both experimental and theoretical research.
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Chemical biology of antigen presentation by MHC molecules
MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.
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Squaramide-based interpenetrated networks for load-bearing applications
This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.
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Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor
During the course of drug discovery translational steps are made.
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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Systems pharmacology-based translational drug pharmacokinetics
High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.
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Exploring and exploiting CD8+ T cell proliferation
PhD defence
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Immune cell networks in Inflammatory Bowel Disease
PhD defence
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Organisation
The Leiden Academic Centre for Drug Research (LACDR) is responsible for the research and education in Bio-Pharmaceutical Sciences carried out at Leiden University.
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Deep imaging
A computer can look at, and learn from, many more images than a human specialist. AI systems are rapidly becoming indispensable for medical and biological applications. But they still have to learn how to explain their decisions.
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Inverse Agonism and Constitutive Activity
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Formulation and Characterization of Vaccines
Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…