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1,959 search results for “staten cell technology” in the Public website

• Contact Cell Systems and Drug Safety

  Division contact information & address

• 
  Dario Bijker Technician

  Faculty of Science

• 
  Kostas Tassis Analyst

  Faculty of Science

• 
  Myrtille Koerselman Management assistant

  Faculty of Science

• 
  Nasi Liu PhD candidate

  Faculty of Science

• 
  Marjolijn Lugthart Office Manager

  Faculty of Science

• Martijn Moné

  Martijn Moné is the scientific project manager within the Division of Cell Systems & Drug Safety, and is involved in structuring and coordinating international research projects.

• 
  Matthijs Vlasveld PhD candidate / Guest

  Faculty of Science

• Cannabinoid receptor 2 as a ‘drugable’ target: kinetic profile of novel receptor ligands Research project

  Supervisor: Andrea Martella

• Direct and two-step activity-based profiling of proteases and glycosidases Research output

  Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

• Piecewise deterministic Markov processes: an analytic approach Research output

  Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

• Chemical tools to monitor and control human proteasome activities Research output

  Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

• NeCEN Research facility

  With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…

• Key publications Cancer Drug Target Discovery

  Key publications of the Cancer Drug Target Discovery group

• Lipid bilayers decorated with photosensitive ruthenium complexes Research output

  Promotor: E. Bouwman, Co-promotor: S. Bonnet

• The role of 14-3-3 proteins in ion homeostasis in the yeast Saccharomyces cerevisiae Research project

  We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.

• Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana Research output

  Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

• Zipping into Fusion Research output

  Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

• Towards photo-CIDNP MAS NMR as a generally applicable enhancement method Research output

  Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

• Inhibitor discovery of phospholipases and N-acyltransferases Research output

  In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

• Macrophages and atherosclerotic lesions Research project

  Macrophages and atherosclerotic lesions The infiltration of monocytes in the arterial wall, their differentiation to macrophages, and the subsequent accumulation of cholesterol in these macrophages initiate the process of atherosclerosis. We study the importance of specific genes in macrophages for…

• François Mesnard 16th International Metabolomics Workshop

  PhD at Université de Picardie Jules Verne, Amiens - France

• Master Projects Huber Lab

  Master projects are available in

• Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs Research output

  Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

• Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation Research output

  In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

• In vivo modelling of Ewing sarcoma in zebrafish Research output

  Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

• The Netherlands X-omics Initiative Research project

  The Netherlands X-omics Initiative is a new facility as part of the National Roadmap for Large-Scale Research Infrastructures. It is partly funded by NWO with a total budget of 40 million euro. The project started on September 2018 and will last for ten years.

• Drug discovery and development

  New or improved treatments for chronic and acute illness.

• Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice Research output

  In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

• Kinetics for drug discovery – The first step towards an improved drug discovery paradigm Research project

  Supervisor: Indira Nederpelt

• 
  Nils Thonemann Assistant professor

  Faculty of Science

• 
  Vincent Niochet PhD candidate

  Faculty of Archaeology

• 
  Vanessa Mak Scientific Director / Professor

  Faculteit der Rechtsgeleerdheid

• Artisans versus nobility? Research output

  Multiple identities of elites and ‘commoners’ viewed through the lens of crafting from the Chalcolithic to the Iron Ages in Europe and the Mediterranean

• Gitlab Cell Observatory

  GitLab is a single application for the entire software development lifecycle. We use the Leiden University gitlab services

• Microscopy Cell Observatory

  Visualising structures of life

• The use of activity based protein profiling to study proteasome biology Research output

  Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

• Facilities Dutch Extract Library

• Patient-derived models of breast cancer: a breakthrough story of the duct Research output

  To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

• Accelerating the Photocatalytic Water Splitting in Catalyst−Dye Complexes Research output

  As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

• The domestic implements of the Single Grave Culture: the case of the Noord-Holland province Research project

  The use-wear analysis of domestic implements provided new insights of the Single Grave Culture population in the Netherlands.

• 
  Martina Revello Lami Assistant professor

  Faculty of Archaeology

• Research Supramolecular & Biomaterials Chemistry

  Research at the SBC group is comprised of the following research themes:

• Research ecosystem Discovering and developing drugs

  The chain that supplies patients with new medicines consists of various complex links: from fundamental research to clinical tests and production. This entire chain is represented in Leiden. Leiden University, the Leiden University Medical Center (LUMC), and the companies on the Leiden Bio Science Park…

• Worm and stomach bacteria: our allies in the battle against allergic asthma Research Dossier: Immunity, Infection and Tolerance

  Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.

• Oncode Accelerator Research project

  Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…

• Leiden University Medical Center Institutes

  The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.

• Towards artificial photosynthesis: resolving supramolecular packing of artificial antennae chromophores through a hybrid approach Research output

  Promotor: H.J.M. de Groot

• Boosting the immune system to fight anitibiotic resistant Tuberculosis Research project

  Can small molecule drugs restore the immune system’s ability to fight tuberculosis by boosting autophagy?

• Feeding on the fat: how mycobacterial infections disrupt lipid metabolism Research project

  How do pathogenic mycobacteria alter lipid metabolism in human cells and patients, and which disrupted pathways could be targeted for new antibiotics?