Promotor: M. Ubbink, Co-Promotor: R. T. Dame

Promotor: M. Ubbink, Co-promotor: G. Siegal

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

Assistant Professor at the Department of Analytical Chemistry, Radboud University Nijmegen, the Netherlands

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

Hydrogen peroxide (H2O2) generation via electrochemical oxygen reduction is a sustainable production method for this bulk chemical. However, the selectivity of molecular catalysts for electrochemical H2O2 generation has hardly been investigated in a systematic manner, and it is unknown if their stability…

Promotor: Prof.dr. M. Ubbink

We report new computational and experimental evidence of an efficient and astrochemically relevant formation route to formaldehyde (H2CO). This simplest carbonylic compound is central to the formation of complex organics in cold interstellar clouds and is generally regarded to be formed by the hydrogenation…

Hydrogen peroxide (H2O2) is an important bulk chemical that is used in various industrial processes. More than 95% of the H2O2 used in industry is made via the anthraquinone process during which a large amount of energy is going to waste.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

This perspective addresses four challenges facing theorists whose aim is to make quantitatively accurate predictions for reactions of molecules on metal surfaces, and suggests ways of meeting these challenges, focusing on dissociative chemisorption reactions of H2, N2, and CH4.

Pancreatic ductal adenocarcinoma (PDAC) is the deadliest common cancer, with only 8% of patients surviving for five years. One reason for this poor outcome is that current chemotherapy treatments are highly toxic, often leaving patients too sick to receive treatment or forcing doctors to lower the dose…

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Promotor: Prof.dr. G.J. Kroes

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Should the law and norms applicable to armed conflict include a distinct category covering the transition from armed conflict to peace, jus post bellum, and if so what are its characteristics?

The Institute of Education and Child Studies is part of the Faculty of Social and Behavioural Sciences at Leiden University. The institute is governed by an Institute Board under the direction of a rotating chairman, i.e. the Scientific Director and an Director of Studies. The Institute Board is…

In this minor you will get an insight in Dutch as well as international public administration. You will study local, national and international levels of government such as the European Union, and (semi-) public and private organizations that carry out a variety of public tasks.

In 2020, Leiden University launched its stimulated interdisciplinary programs, including one focused on regenerative medicine.

The work of judges can also be done by AI systems. These systems can formulate an objective proposal for a ruling. But such proposal should always be checked by a judge, says Bart Custers.

The Centre for Science and Technology Studies (CWTS) ensures that its research practices align with its commitment to inclusion, responsible evaluation, and open science. Our policies and guidelines provide clear principles for ethical research conduct, data management, sustainable travel, PhD supervision,…

This project investigates the role of art in the public and academic debate on biosolar energy

AI MAPS adopts a freedom and social well-being perspective and focuses on three themes to address key security challenges; Social disorder and public nuisances in neighbourhoods, High-impact crime, and Crowds and events.

What are the key technical, social, regulatory, economic, and ethical considerations for scaling up ocean-based Carbon Dioxide Removal (CDR) approaches, and what integrated assessment frameworks and governance structures are needed to facilitate their implementation at scale?

Lecture

The Institute of Political Science has a multi-dimensional research programme that promotes the unity of the institute as an intellectual community rooted in the social sciences and especially political science, while enabling overlapping groups of colleagues to develop particular research agendas within…

Institute of Political Science

This research comprises various sub-projects.

The mission of Printeger is to enhance research integrity by promoting a research culture in which integrity is part and parcel of what it means to do excellent research, and not just an external and restrictive control system.

Abbas provides an in-depth analysis of the complex interplay between Zionism, Jewish identity, power dynamics, and the Israeli-Palestinian conflict.