Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Discovery of metastasis promoting candidate drug targets

The skin protects the body from unwanted influences from the environment as well as excessive water loss. The barrier function of the skin is located in the stratum corneum (SC).

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

PhD defence

PhD defence

For more information regarding ongoing research projects, please contact Dr. Ilze Bot.

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime and NIS-elements

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

Developing a clinical decision support tool that will make it easier for clinicians to personalise the treatment for patients with high blood pressure. The team is using AI, deep learning methods and patient cohort data from 11 European countries.

During the course of drug discovery translational steps are made.

PhD defence

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

The specialisation enables you to understand the fundamentals of management and entrepreneurship alongside high quality Bio-Pharmaceutical research at a world class institute.

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

Transcutaneous vaccination is attractive because it is non- or minimally invasive, pain free and the site of administration (skin) is easily accessible. What’s more, transcutaneous immunization can lead to a strong immune response owing to the presence of immune-competent cells in the skin.

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

PhD defence

VVIK Lecture

This thesis discusses the development in Proto–Indo–European, Latin and Romance of a word–formation pattern which the most adequate terminology in use dubs ‘verbal government compounds with a governing first member’; I use the shorthand ‘pickpocket compounds’.

Ariadne Schmidt, Isabelle Devos and Julie de Groot provide you with refreshing insights concerning the study on urban singles in the period between 1200 and 1900.

Lecture, China Seminar

The following sources were consulted for this guide:

Do you want to apply for this master’s programme at Leiden University? Find out how to apply for your programme by following the step-by step guide in the application and admission section.

Promotor: G.A. van der Marel, Co-Promotor: J.D.C. Codée

Our education programmes span the entire spectrum of Animal Sciences, Evolution, Biodiversity and Conservation, Microbial Biotechnology and Plant Sciences.

Analecta Praehistorica Leidensia is the annual journal of the Faculty of Archaeology (formerly the Institute of Prehistory), Leiden University.

At Molecular Physiology we teach the following courses within the Leiden Institute of Chemistry's Chemistry and Life Science and Technology programmes.

Leer meer over de Master Education and Child Studies tijdens de Online Master's Open Dagen van de Universiteit Leiden.

FAIR-ASSESS brings together researchers from five different Leiden faculties, as well as experts from outside the university. The project has been initiated by Andrei Poama and is being led by Josette Daemen.

Are you looking for some listening material for the upcoming long weekend? Staff members and alumni of the Faculty of Humanities have been creating various podcasts over the last few months. A selection is shown here:

PhD defence

Lecture, Leids Actualiteitencollege

Inaugural lecture

Inaugural lecture

Inaugural lecture

Until 2019, LUCIS hosted one annual lecture, inviting an eminent scholar to give a large-scale lecture in one of the finer halls at Leiden University. Because of their success, we now organise four larger lectures every year, entitled LUCIS Keynotes.

In his groundbreaking Imagined Communities, first published in 1983, Benedict Anderson argued that members of a community experience a

This publication by Cornelis van Tilburg, will be published at Sidestone Press on September 28, 2022. It discusses various aspects of city gates in the Western Roman Empire: Italy, Spain, Gaul, Germany and Britain.

This dissertation examines how we can reconstruct physical activity by looking at variations in the shape of muscle attachment sites ( ‘entheses’) on the human skeleton. It evaluates two post-medieval contexts; rural Middenbeemster and urban Aalst.

It is with great pleasure that we present to you the second volume of Inter-Section, published in 2016.

The archaeology domain produces large amounts of texts, too much to effectively read or manually search through for research. To alleviate this problem, we created a search system (called AGNES), which combines full text search with entity and geographical search.