Supervisor: Andrea Martella

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

Promotor: E. Bouwman, Co-promotor: S. Bonnet

We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Macrophages and atherosclerotic lesions The infiltration of monocytes in the arterial wall, their differentiation to macrophages, and the subsequent accumulation of cholesterol in these macrophages initiate the process of atherosclerosis. We study the importance of specific genes in macrophages for…

PhD at Université de Picardie Jules Verne, Amiens - France

Master projects are available in

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

The Netherlands X-omics Initiative is a new facility as part of the National Roadmap for Large-Scale Research Infrastructures. It is partly funded by NWO with a total budget of 40 million euro. The project started on September 2018 and will last for ten years.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Supervisor: Indira Nederpelt

With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…

GitLab is a single application for the entire software development lifecycle. We use the Leiden University gitlab services

Visualising structures of life

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

The Joan van der Waals colloquium is an ongoing bi-weekly lecture series.

Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.

Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…

Promotor: H.J.M. de Groot

Can small molecule drugs restore the immune system’s ability to fight tuberculosis by boosting autophagy?

How do pathogenic mycobacteria alter lipid metabolism in human cells and patients, and which disrupted pathways could be targeted for new antibiotics?

The use-wear analysis of domestic implements provided new insights of the Single Grave Culture population in the Netherlands.

Cryptocurrencies have exploded onto global financial markets, with the value of a single bitcoin growing from around 800 USD in 2016 to 67,000 USD in 2021.

Muhammad Adlin Sila examines the range of ways Bima Muslims constitute their Islamic identities and agencies through rituals and festivals. In response to their surroundings, what it means to be a Muslim is constantly being negotiated.

The mission of our group is understanding how science communication works to improve the interaction between science and society. We believe better science communication can improve our society and engage many different groups with science, also improving science.

The authors delve into the varying degrees to which institutions across different nations connect foreign events to their respective country's domestic affairs.

On the 21st of September, Carlos Benítez-Torres successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Carlos on this achievement!

The fourth volume of Ex Novo has the pleasure to host Heleen van Londen, Marjo J. Schlaman, and Andrea Travaglia as guest editors of the special issue titled The Natural and The Cultural. Integrating Approaches in Landscape Heritage Management. This timely collection of peer-reviewed papers and short…

This research cluster is a part of the Institute of Political Science’s research programme ‘Institutions, Decisions and Collective Behaviour’. Its members investigate the drivers of political conflict and various types of crises. They study how citizens, political institutions and international organizations…

This webpage is for companies interested in becoming an internship partner.

Harvesting rice from the same field, without planting new rice plants? A discovery may bring this scenario closer. Leiden scientists have discovered a gene that allows annual plants to grow after flowering, instead of dying. Publication on 13 April in Nature Plants.

Promotor: Prof.dr. C.A.M.J.J. van den Hondel, Dr. ir. V. Meyer, Co-promotor: Dr. A.F.J. Ram

There are several training oportunities within the cell observatory

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.