Sarah Giest, Assistant Professor at Leiden University, and Ishani Mukherjee researched the topic of 'Behavioural Insights Teams (BITs) and Policy Change: An Exploration of Impact, Location, and Temporality of Policy Advice'.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

At Leiden University we believe it is important that you receive the right kind of support in your choice of study and while you study. This is why we use what we call the ‘Leiden study system’ to help you make a success of your study from start to finish.

SMR can be used to measure the mass of adsorbed protein to nanoparticles with a high precision in the presence of free protein.

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

The more than 370 sensors that have been hung up in Leiden University buildings to count the people present will not be switched on again. The equipment will eventually be removed from the buildings.

Following its foundation in 1575, Leiden University was quick to incorporate Roman goddess Minerva in its coat of arms. This explains why Rembrandt’s Minerva from 1635 can be seen on the façade of the Academy Building, which has been in use by the University since 1581. This is where, in the Senate…

Arco Timmermans, professor by special appointment in Public Affairs at the Institute of Public Administration, is co-editor of this book focused on comparing engagements in policy advisory systems.

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

During the early modern period, many medieval manuscripts were cut up into strips of parchment which were reused to reinforce the bindings of newly printed books. Until recently, these reused pieces of medieval manuscripts only came to light when the early modern book binding was damaged and/or subjected…

The Dutch Advisory Committee on Public International Law has, on its own initiative, provided advice to the Dutch government regarding the duty of third states to prevent genocide under the Genocide Convention. The Committe's advice addresses the legal uncertainty in political and societal debates about…

Online presentations of our regular master’s programmes were held from 11 to 19 May. Would you like to see them again? Check out our full range of programmes below!

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

On 2 April 2025, Anna Marhold, a member of the Peace and Security Committee of the AIV and Assistant Professor at the Grotius Centre for International Legal Studies, joined a technical briefing to parliament providing advice on hybrid threats and societal resilience.

At the annual conference of the Nederlandse Vereniging voor Wetgeving (the Dutch association for legislation) that was held in the Auditorium of the Ministries of Internal Affairs and Kingdom Relations and Justice and Security in The Hague on Thursday 6 October, Gert Jan Geertjens defended the draft…

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.

Source: Bioorg Med Chem, Volume 23, Issue 14, pp. 4034-49 (2015)

Students in the third year of the BA International Studies programme follow the Practicing International Studies (PRINS) consultancy course. They conduct a project put forward by real clients and then present them with their research results. PRINS is so successful that it has now been running for 10…

The discovery of new medicines is a tedious and lengthy process. On average, over 10,000 molecules need to be studied for one to become a drug and reach the patient. Part of that process are the very costly clinical trials in humans, and candidate drugs often fail due to side effects or lack of efficacy.…

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

Promotor: A.P. IJzerman