This thesis focusses on the temperature structure in protoplanetary disks. The relation between structures seen in the dust and gas-phase molecules is investigated.

Public International Law is a one-year Master’s specialisation at the internationally acclaimed Leiden Law School at Leiden University. The programme focuses on the legal framework that governs international relations in an increasingly complex global society.

Are you ready to take on an extra challenge during your Leiden Master programme?

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

On Thursday 28 January 2016, Prof. Carsten Stahn contributed to the OPCW Sub-Working Group on Non-State Actors, together with Professors Andrew Clapham (Geneva) and Dapo Akande (Oxford), in the presence of the Ahmet Üzümcü, Director-General of the OPCW.

The Summer School ‘The European Union, the United Nations and Global Governance’ will focus on a range of topics relevant to interactions between the European Union (EU) and the United Nations (UN) and the EU’s role within current patterns of global governance.

PhD student Robbin Bastiaansen applies mathematics to get insight in practical problems. By comparing mathematical models with developments in existing ecosystems, he hopes to demystify the process of desertification. His research has been published in Proceedings of the National Academy of Sciences…

Inhibiting specific protein production in the human body can serve as a crucial weapon in the fight against Alzheimer's, Eline van Maanen believes. PhD defence 23 November.

International organisations that represent collaborations between States are becoming increasingly more powerful, and they have an increasing impact on our daily lives. For example, the European Court of Human Rights in Strasburg established that minors have a right to legal aid immediately following…

Vibrating carbon monoxide molecules adsorbed at the surface of a salt crystal stop moving after a few milliseconds. Scientists now discovered this is dominantly due to the emission of electromagnetic waves. The role of the chemical bond at the surface thereby appears to be less important than previously…

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Is the quality of the current supervision and enforcement by the government such that companies that work with large quantities of hazardous substances are brought into compliance with legislation and regulations?

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

Testing chemical substances without using animals. It seems a utopia, but a European team is going to develop a way to make this a reality. The RISK-HUNT3R project, led by Leiden professor Bob van de Water, received 23 million euros from the European Commission for this purpose. The project was launched…

Study information, Experience Day

Study information, Experience Day

An international team of researchers, including Federico Calle-Vallejo of Leiden University’s Institute of Chemistry, have taken the atomic-scale design of catalysts to the next level. Their research contributes to the quest for a method to generate or store energy more efficiently. The report is published…

We would all like to live in a world in which individuals feel safe, conflicts are resolved peacefully and the interests of future generations are taken into consideration. At Leiden University legal scholars investigate to what extent public international law meets the needs of a globalised society.…

To cover up their deportation plans which targeted Polish Jews in the Warsaw Ghetto, the Nazis re-opened schools. In her inaugural lecture, historian Sarah Cramsey demonstrates with examples how care was used ‘as a weapon’ during the Holocaust. She also stresses that care is a unifying cement in society…

A group of chemists, that includes Sander van Kasteren and Hermen Overkleeft, has discovered that azides, a certain type of chemical compound, can determine whether or not T cells respond to or ignore a vaccine. Their discovery is set to be published in Angewandte Chemie.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

Thomas Bakkum en Tom van der Wel, two PhD candidates from the Leiden Institute of Chemistry, have both won poster prizes at the EMBL Chemical Biology Conference 2018 in Heidelberg.

Toxys, Leiden University and Leiden University Medical Center have agreed immediately to commercialise and also develop further the ToxProfiler technology invented at the two institutions. ToxProfiler allows for rapid toxicity hazard identification of novel and existing drugs, chemicals, and other substances.…

What chemicals do plants have available, and what happens if they use them when faced with bacteria or fungi? That is what PhD candidate Luis Salomé Abarca is keen to learn. He studies plants’ survival and their use of chemical components in communication and defence. Salomé Abarca works at the Natural…

If you could convert CO2 into building blocks for other molecules with the help of electricity, you could make the chemical industry considerably more sustainable. Leiden chemists have unravelled a fundamental part of this process and applied this knowledge in a real device, as they write in Nature…

The American Chemical Society’s Publication Division (ACS) and Dutch universities represented by the VSNU have reached agreement on including open access publication as part of the contract with publishers. From 2017, all new articles submitted by an author associated with a Dutch university or participating…

Bhumika Gupta (21), International Studies alumna, secured an internship in the OPCW, the Organisation for the Prohibition of Chemical Weapons. She has set a path for herself, leading towards the job of her dreams, and this internship is a big step towards that future job.

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

This thesis highlights the significant role of surface geometry and oxidation state in determining CO adsorption behavior on copper surfaces.

How do we address the society’s most pressing issues through governance? The Master of Public Administration gives you a unique research-led multi-level perspective on the practice of management, steering, and coordination of political, economic and societal actors, with three specialisations to suit…

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

The Dick Stufkens Prize 2018 for the best PhD thesis of the Holland Research School of Molecular Chemistry (HRSMC) will be awarded to Dr Stefan Vuckovic. In his thesis, Vuckovic presents a new and innovative approach to the quantum mechanical calculation of atomic and molecular energies. It lays the…

It is one of the most talked-about subjects right now: how do we eradicate sexual harassment and violence? Alumnus Femke Eisma is the spokesperson for Mariëtte Hamer, the government commissioner tasked with tackling this persistent social problem. Eisma studied the Dutch language at Leiden. How is her…

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

The bacterium Vibrio cholerae is a serious threat to our health because it is the causative agent of cholera. Worldwide, over a billion people per year are at risk of cholera infection. New strains of V. cholerae are resistant to the multiple drugs used to treat cholera, meaning that new types of drugs…

The aim of ANCIENT CHARM was to develop neutron-imaging techniques and the associated equipment, and help establish neutron imaging as a mainstream archaeological analytical technique. In particular, one of the goals was a new imaging technique which called neutron resonant capture imaging combined…

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…