How does stress influence cognitive performance? What is the role of selective attention to threatening information in this effect? Could we prevent stress-induced decline of cognitive performance with pharmacological interventions? Could we use resting state theta/beta ratio as a biomarker for cognitive…

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

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Voor zowel archeologen, paleontologen en geologen als vrijwilligers in de archeologie en paleontologie is het geen verrassing meer dat op de stranden van de Nederlandse kust fraaie vondsten gedaan kunnen worden. Vele artikelen, boeken, tentoonstellingen, congressen, lezingen, ‘zoekdagen’, krantenberichten,…

Hoe kan de City Deal Kennis Maken bijdragen aan het formuleren van maatschappelijk relevant onderzoek dat de stad in al haar diversiteit centraal stelt? In de stad Leiden zijn burgers momenteel maar in beperkte mate betrokken bij het bepalen van de agenda van de lokale City Deal Kennis Maken. Dit onderzoeksproject…

Foute taal? Bestaat niet!

In February 2015, Al Shabaab produced a video in which it calls for an attack on malls in the United States, Canada and the United Kingdom.

Covid-19 is een disruptieve ontwikkeling die hier en nu veel vraagt van zorgprofessionals, bestuurders en managers. Hoewel de crisis nog volop bezig is, is nu al duidelijk dat het Coronavirus een blijvende impact zal hebben op zorginstellingen en fundamentele vragen oproept over hoe we onze zorg optimaal…

More on the Dutch webpage.

Ali Al Tuma, PhD candidate at the Leiden University Institute for History, has won the Sharjah Award for Arab Creativity for his play ‘Yusuf Melik Espanya’ (Yusuf King of Spain), that tells the story of a young Moroccan whose brothers conspire to send him off, against his will, to the Spanish Civil…

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

Onlangs verscheen het boek ‘Afgrond zonder vangnet’ van Yra van Dijk, hoogleraar Moderne Nederlandse Literatuur. In haar boek analyseert ze verschillende thema's in het werk van Arnon Grunberg.

Met AI kunnen nieuwsredacties razendsnel beelden genereren — maar tegen welke prijs? Dit onderzoeksrapport opgesteld door prof. dr. Jaap de Jong, dr. Astrid Vandendaele, Maartje van der Woude en Stef Arends (Universiteit Leiden), baseert zich op 59 interviews met beeldmakers, redacteurs en experts uit…

There are effective treatments for people with autism, says Wouter Staal, professor of Autism Spectrum Disorders, in his inaugural lecture on 4 May. However, it is not yet clear which treatment is most effective for which individual.

During the 19th International ICE-IEEE ITMC Conference on Engineering, Technology and Innovation (ICE), 24-26 June 2013, The Hague, The Netherlands, Christoph Stettina et al. won the best paper award.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

Which intervention technique is more effective in reducing public speaking anxiety in children aged 9 – 12 years, exposure or restructuring cognitions?

PhD defence

Aan de hand van bekende en minder bekende voorbeelden uit de wereld van politiek en media laat dit boek zien hoe je strategisch gebruik én misbruik kunt maken van taal.

Children with a specific phobia are excessively afraid of certain objects, animals or situations. Specific phobias are common in children, but they can make the child’s life at home, school and outside quite difficult. Together with a large international team, we developed the KibA-program to help children…

Mattias Brand defended his thesis on 10 April 2019

Studies over tien eeuwen leescultuur

Dit proefschrift beschrijft een collectie aan alternatieve strategieën voor het begrijpen, ontwerpen en toepassen van lipide nanosystemen, waarin de rol van de bio-nano interacties centraal staan. In het bijzonder wordt gekeken naar de interactie van RNA-lipide nanosystemen, bekend van de toepassing…

For a long time it has been thought that habitation and landscape organisation only changed significantly from the Roman Period onwards. However, many developments were already started long before Julius Caesar's Roman armies arrived in the southern Netherlands.

Peer-mentored cognitive behavioral therapy for adolescents with mild intellectual disability and anxiety disorder

Social anxiety disorder is one of the most common disorders in children and young people. Social anxiety is characterized by excessive fear and avoidance of social situations. The primary fear in children with social anxiety is that they will be negatively judged by others. To date, the most frequently…

Er zijn structurele (sociale) veiligheidsproblemen in vrouwengevangenissen, blijkt uit onderzoek van Leidse onderzoekers Esther van Ginneken en Yara Abbing. Universitair hoofddocent Van Ginneken sprak met Trouw: ‘We moeten macht, seksualiteit en discriminatie bespreekbaar maken.’

Op zaterdag 3 juni vindt de Museumnacht Leiden plaats. Ook dit jaar zijn Leidse wetenschappers en studenten onderdeel van de programmering.

The major aim is to develop, evaluate, and implement disease-generic cognitive-behavioral interventions through the internet in order to optimize tailored health care for patients with chronic somatic conditions.

A step-by-step approach to building confidence in anxiety-prone young children.

Professor by Special Appointment of Clinical Neuropharmacology Geert Jan Groeneveld will deliver his inaugural lecture entitled ‘The importance of the biomarker’ on 11 March 2022. According to him, new genetic knowledge will revolutionise drug research.

Op donderdagmiddag 15 mei 2025 organiseert Universitaire Bibliotheken Leiden het symposium ‘De Middeleeuwen als inspiratiebron’. Aanleiding voor dit symposium is de publicatie van het rijk geïllustreerde publieksboek 'Schatten op schrift, 50 manuscripten uit middeleeuws Europa'.

Primary Objective: The primary aim of the proposed RCT is to evaluate whether LF-TLP in blended form as an indicated prevention for anxiety complaints is more (cost-) effective than TAU according to the NHG guideline Anxiety. We hypothesize that in comparison to TAU, LF-TLP will result in a significantly…

Het is een wijdverbreid idee dat (post-)middeleeuwse steden een sterfteoverschot hadden en zij slechts in leven konden blijven door de toestroom van migranten; een fenomeen dat bekend staat als het ‘urban graveyard’-effect. Over details valt te twisten, maar duidelijk is dat de stad en de dood dichter…

Coen van Hasselt’s pharmacology group collaborated on a study recently published in the renowned Lancet Infectious Diseases. The international team mapped the antibiotic treatment of the life-threatening inflammatory reaction sepsis in newborn babies. They did this for low- and middle-income countries,…

De decentralisaties van de zorg aan langdurig zieken en ouderen, jeugdzorg, en werk en inkomen die vanaf 2015 zijn doorgevoerd in Nederland hebben geleid tot een transitie van een centraal naar een lokaal stelsel van zorg en welzijn. Deze transitie beoogt zorg en ondersteuning dichter bij de inwoners…

In welke mate hebben domaniale structuren de machtsvorming en nederzettingsontwikkeling in en van het gewest Holland bepaald?

Although exposure therapy is the gold-standard treatment of posttraumatic stress-disorder (PTSD), only half of the patients adequately benefit from it. Based on recent insights into the mechanisms of extinction, this project examines strategies and techniques to improve exposure treatment outcome in…

Vanessa Frodermann, a PhD student at the Biopharmaceutical department of the Leiden Academic Centre for Drug Research, has discovered that arteriosclerosis could be inhibited by cellular therapy. Arteriosclerosis is one of the leading causes of the development of cardiovascular disease. Her PhD defence…

The ‘Leer te Durven!’ program (Learn to Dare) is a preventive training program for children with mild anxiety symptoms (Simon & Bögels, 2014). The program has been developed for children between the ages of 8 and 12 who feel or behave anxiously, avoid situations, are afraid of doing things wrong, appear…

Although domestic violence often affects multiple family members, parents and children are usually treated separately for their traumatic experiences. In collaboration with women's shelter Rosa Manus, forensic partner the Waag, the municipality of Leiden and their colleagues from LUBEC (Leiden University…

Expats in the Netherlands receive a much warmer reception than other migrants, Leiden University's Aniek Smit has discovered. ‘But municipalities need to pay more attention to the differences between expats and the effects of their presence on other residents.' PhD defence 25 January.

This research will focus on the relationship between the musical structure and musical time in the performance of 19th century music.

Early treatment benefits patients who have not fully developed rheumatoid arthritis but are in the preliminary stages of the disease. This is what researchers from the Leiden University Medical Centre (LUMC) have reported in The Lancet. Patients in the pre-arthritis stage who were temporarily prescribed…

Anxiety disorders, like specific phobias, are among the most prevalent mental health disorders that may hinder children in their development. Cognitive Behavioral Therapy (CBT) is considered an effective treatment for childhood anxiety. After treatment, children are encouraged to practice at home with…

Tuberculosis causes 1.5 million deaths yearly and anti-tuberculosis therapies are threatened by emergence of drug resistance. Development of innovative drug combinations should be accelerated with the use of translational pharmacological models. Moreover, host-directed therapies (HDT), which stimulate…

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.