Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri

Though tuberculosis can be cured today, new resistant strains of the bacteria are becoming a growing problem in the medical world. Biologist Annemarie Meijer and her colleagues are studying resistance to this disease. Their research is already yielding several interesting clues that could help the development…

More than 1.3 million people worldwide die of tuberculosis (TB) each year, making research on its prevention and control essential. Researchers from various disciplines in Leiden are studying TB. A symposium on 24 March will highlight different activities in the hope of boosting nationwide collabora…

Like ants, termites and bees, some bacteria work together as a multicellular group. There is a strict division of labour in such colonies, to make the group more resilient to the outside world. Now researchers have found that some parts of the bacterial colony can take ‘for the greater good’ to a whole…

Identifying natural plant-associated bacteria that provide targeted inhibition of pathogens through the production of antimicrobial peptides.

The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

A team of researchers at the Institute of Biology Leiden, in collaboration with scientists from Utrecht University, has discovered a novel approach to improve the production of antibiotics and enzymes in the soil bacteria Streptomycetes.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

The CMCB brings together a diverse range of unique expertise in microbial cell biology. Members of the CMCB investigate both model and non-model organisms, bacteria and archaea, pathogens and non-pathogens.

Hermeneutics and the Humanities: Dialogues with Hans-Georg Gadamer / Hermeneutik und die Geisteswissenschaften: Im Dialog mit Hans-Georg Gadamer

Despite substantial progress in understanding tuberculosis (TB), the eradication of the TB epidemic is still far from reach.

Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…

Despite the field’s general agreement that pyrotechnology had a significant impact on the cultural evolution of humankind, our understanding of the origins and development of fire use and its role in humankind’s cultural evolution is very limited, blurred by strong disagreements over its chronology…

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Antibiotics are a class of medicine most people take for granted. But pathogenic bacteria are becoming more and more resistant to our antibiotics, and this poses a great challenge for future treatments. There is thus a great societal need to identify new molecules that can address new targets and be…

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

Melanie Fink, Postdoctoral Researcher at the Europa Institute of Leiden University, has published her book Frontex and Human Rights, Responsibility in 'Multi-Actor Situations' under the ECHR and EU Public Liability Law. This work is based on her doctoral dissertation, which she defended in December…

The CMCB comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC) and the Leiden University Medical Center (LUMC).

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

What are the patterns and processes of human mobility in the pre-colonial circum-Caribbean as revealed by burial populations and what are the underlying motives and socio-cultural principles on both micro- and macro-scales?

The intestinal bacterium E. coli can adapt to changes in its surroundings. Leiden scientists have discovered how the H-NS protein makes this possible. This new knowledge can be an important starting point in combatting bacteria and diseases such as peritonitis. Publication 2 October in the journal e…

How do plants lure microscopically small 'support teams' into their roots for protection against diseases? And what functions are activated in the microbes and the plants?

Pathogenic bacteria are increasingly resistant to today’s antibiotics. Professor Gilles van Wezel seeks new forms of antibiotics in good bacteria that live in the soil.

The currently available in vitro generated human skin equivalents resemble the human skin in many aspects. However, some essential barrier characteristics do not fully mimic the native barrier. Consequently, the human skin equivalents cannot be used for screening of drugs for skin penetration.

Plastics are an intrinsic part of our society. Annually, 400Mt of plastics are produced of which roughly 40% is discarded within a year.

How do pathogenic mycobacteria alter lipid metabolism in human cells and patients, and which disrupted pathways could be targeted for new antibiotics?

This article discusses the degree of independence that is required for national human rights institutions to function successfully.

On 1 October 2019 the Hazelhoff Centre for Financial law hosted its 19th guest lecture starring Paul Sharma, managing director at Alvarez & Marsal and co-head of the European Financial Industry Regulatory Advisory Services practices.

Leiden’s Faculty of Humanities is one of the broadest of its kind, offering courses in no fewer than 80 different languages and a very broad spectrum of academic disciplines.

The Faculty of Humanities

The Faculty of Humanities has 8 institutes:

In the Humans of Humanities series, we will do a portrait of one of our researchers, staff members or students, every other week.

The opportunistic bacterium Burkholderia cenocepacia is feared by cystic fibrosis patients and is emerging in hospital-acquired infections. An international study sheds new light on the infection mechanism of this opportunistic pathogen that may have large implications for treatment strategies.

As a Faculty of Humanities graduate you are part of a valuable network. Discover how you can remain in contact with other alumni and the University!

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

Tackling human trafficking has been a priority on international, national and local policy agendas for some decades now. Yet a number of knowledge gaps stand in the way of how the issue is approached. Interdisciplinary research is essential if we want to expand our knowledge to benefit policy and pr…

Are Weyl particles the ideal conductors? Do cells without a cell wall play a role in chronic Tuberculosis infections? Carlo Beenakker and Dennis Claessen want to answer these questions. They both received a KLEIN grant from the NWO. With these grants, NWO wants to stimulate innovative, fundamental r…

Research in the Lars Jeuken group focusses on redox-active proteins and membranes enzymes, aiming to understand bacterial respiration at the molecular level for the development of antimicrobials and semi-artificial photo-synthetic cells.

The HARVEST project explores the dietary choices that our hominin ancestors and relatives made, by recovering information on what they consumed, and how factors like environmental variation, intrinsic biology, and development of food processing technologies could have influenced their decisions.

In this thesis I examine how soil biotic and abiotic characteristics change and interact throughout the course of afforestation and how they subsequently impact tree performance.

Environmental Humanities is one of the LUCAS research themes, bringing together members of the three LUCAS clusters.

Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Lars Jeuken, Anne Wentink, Sebastian Geibel, Anjali Pandit, René Olsthoorn, Alia, and Steffen Brünle.

The Human Origins group at Leiden University studies the archaeology of hunter-gatherers, from the earliest stone tools in East Africa, more than three million years old, to the origin of sedentary societies towards the end of the last ice age.

Humanities Campus Project is the name of the redevelopment of the Witte Singel-Doelen Complex, the location of the Faculty of Humanities and associated knowledge partners and institutes. Over a period of ten years the complex will undergo a gradual metamorphosis, while classes continue to be taught.…

At the Humanities Hub, researchers can immerse themselves in the world of Digital Humanities, while students get the opportunity to develop their digital and media skills within the field of the humanities. The lab spaces of LUCDH, the Faculty of Humanities, and Journalism and New Media provide modern…