In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

This thesis covers various applications of topology in condensed matter physics and quantum information.

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

Leiden Embedded & Real-time Computing (LERC) is an expert lab and leader in advanced research on embedded and real-time systems and software. The main mission of LERC is by its research to contribute in a highly innovative way to the system-level design of embedded and cyber-physical systems and software…

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

This thesis surveys the intersection of computed tomography (CT) and machine learning (ML), treating CT as an ill-posed inverse problem shaped by object properties, imaging physics, and data limitations.

Institute of Environmental Sciences, Faculty of Science, Leiden University

The goal of the MODOMA-project is to create a computer model of language acquisition.

In this project we study the properties of statistical- and rule-learning mechanisms in relation to the acquisition and evolution of language. We ask to what extent these mechanisms are unique to humans - or to human language - by comparing the acquisition of vocal structure in two species: humans (infants)…

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

To what extent can digital technologies be considered as authorities?

Promotor: Prof.dr. J.N. Kok

Simulations of galaxies help researchers understand astronomical observations better. The EAGLE simulation, a large project in which Leiden astronomers play a leading role, shows the evolution of the Universe, from just after the Big Bang to the present day.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Promotor: C.W.J. Beenakker, Co-Promotor: A.R. Akhmerov

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

Data analysis with Python and R are rapidly becoming essential skills for modern scientists. Therefore, we are offering courses to develop your scientific computing skills. Those courses are optional for LACDR PhD candidates.

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

LUMC Technology Focus Area (TFA) Data Analytics is een samenwerkingsverband van verschillende onderzoeksgroepen in het LUMC die nieuwe kwantitatieve en computationele methodologie ontwikkelen voor biomedisch en klinisch onderzoek.

Lecture

Accelerating the diagnosis and personalising the management of inherited metabolic diseases.

Natural Computing is the field of research that investigates both human-designed computing inspired by nature and computing taking place in nature, i.e., it investigates models and computational techniques inspired by nature and also it investigates phenomena taking place in nature in terms of information…

We review the state-of-the-art in the theory of dissociative chemisorption (DC) of small gas phase molecules on metal surfaces, which is important to modeling heterogeneous catalysis for practical reasons, and for achieving an understanding of the wealth of experimental information that exists for this…

Most of current public-key cryptography is considered insecure against attacks from sufficiently powerful quantum computers. Post-quantum cryptography studies methods to secure information resistant against such attacks. One proposal is isogeny-based cryptography, which bases its security on computational…

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

Promotor: S.J. Edixhoven

Nonparametric Bayes for high-dimensional models: contraction, credible sets, computations

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Can we use quantum computers in a way that is also relevant to society? With the help of a 2-million-euro NWA grant, Leiden University will work with partners such as Surf, Google and Volkswagen to demonstrate that quantum computers are also of value outside the lab.

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

The 18.8 million euro NWO Zwaartekracht grant for quantum software which Amsterdam, Delft and Leiden landed collectively, means for Leiden University among others the appointment of two new permanent scientific staff members, who will each form their own research group, divided among Computer Science,…

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

Physicist Martin van Exter works with light at nanoscale, at the forefront of nanocomputer research. But as Director of Education he also has a vision for physics teaching. Inaugural lecture 18 November.

Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)

Engineering an efficient microbial enzymatic polyethylene degradation pathway via an innovative combination of biochemistry and computational biology tools for enzyme discovery and characterization.

Lecture, CHiLL series

In a global effort, quantum computers are rapidly being developed. In the meantime, researchers have to learn how to write code for these devices, which are fundamentally different from conventional computers. A collaboration of scientists led by Google, and including physicists from Leiden and Delft,…

If computers work on superconducting current, they won’t consume any energy. Leiden physicists have now gained control over a new type of superconducting memory elements. Publication in Nature Communications.

Europe's latest quantum computer is set to arrive in the Netherlands. The Dutch IT cooperative, SURF, which supports education and research institutions, has secured funding from the European EuroHPC programme to make this possible. Researchers from Leiden University will play a key role in the project,…

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

This thesis proposes multiple paths towards the development of a performance practice in Computer Music.