Leiden alumnus and writer Tomas Lieske has published a novel which is set in the house of Paul Ehrenfest. Ehrenfest was a famous physicist who organized round table events every Wednesday evening at his home in Leiden in the early twentieth century. The big names from modern physics frequented these…

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Sonic Modernities situates Southeast Asian popular music in specific socio-historical settings, hoping that a focus on popular culture and history may shed light on how some people in a particular part of the world have been witnessing the emergence of all things modern.

A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational…

PURPOSE: The aim of the study was to develop a cheap and fast method to produce hollow microneedles and an applicator for injecting vaccines into the skin at a pre-defined depth and test the applicability of the system for dermal polio vaccination.

Chinese materia medica (CMM), comprising a diverse array of natural substances from plants, animals, and minerals, has been integral to Traditional Chinese Medicine (TCM) throughout history. This study investigates the dynamic evolution of CMM, noting shifts in species for improved therapeutic effects…

Assistant Professor Vedran Dunjko and his team received a gift from Google to support their quantum research. The research focuses on whether quantum computers can provide new ways of understanding the mysteries of high-energy physics.

World War II is never over for those who have lived through it. This is the conclusion of Cleveringa Professor Carol Gluck and her students after reading The Assault (De Aanslag) by Harry Mulisch. The book played a central role in Gluck’s honours course.

From 5-7 November 2018, The Hague Program for Cyber Norms held its inaugural conference at Het Spaansche Hof in The Hague, where they were joined by scholars and participants from across the world, for three days filled with four keynotes and 19 presentations during the parallel sessions.

Presents a novel philosophical account of psychedelic experiences, arguing that they can be induced by means other than psychedelics — such as meditation and yoga.

Graphic Novels and Comics have developed from pulp status to an entirely self-contained medium. This form of storytelling is not limited to stories of superheroes but has been used, molded and reshaped to display historical events, classic stories and autobiographical memoirs. But where should you begin…

The Second World War is a never ending experience for those who lived it. This is what Cleveringa professor Carol Gluck and her students concluded following a critical reading of ‘De Aanslag’ by Harry Mulisch. Mulisch’s novel took centre stage in Gluck’s Honours seminar.

The European Union has invested ten million euros in the so-called iNEXT-Discovery consortium. The goal of this new consortium is to enable European researchers to extend innovative structural biology research. The Netherlands Centre for Electron Nanoscopy (NeCEN) is also part of iNEXT-Disovery, which…

For many years, scientists have observed a correlation between Alzheimer’s disease and a surplus of iron in the brain. However, a causal link between the two has not been proven yet. We lack knowledge concerning the specific form of iron that is involved in the development of neurodegenerative diseases.…

From 5 – 7 November the The Hague Program for Cyber Norms will take place at Het Spaansche Hof in the Hague. The theme this year is Behaviour in Cyberspace: Novel Horizons.

Writing a story from the perspective of a Rwandan girl set in Africa is not an easy task. Alumna Cultural Anthropology Ruth Erica did it. Her debut novel The tree with the bitter leaves, in which an important supporting role is played by a student of cultural anthropology, appeared in August 2020.

As an R&D manager, how can you measure the R&D (research and development) performance of your firm? How does knowing the importance of different R&D measures allow R&D managers to formulate more effective strategies to improve their firm’s R&D performance?

CWTS is proud to announce its new research programme for the period 2017-2022.

As part of the ZonMW Antibiotics resistance funding program, the LACDR cluster Systems Pharmacology was awarded €455.255 for a research project to develop novel clinical biomarkers for bacterial infections.

Research at the Leiden University Medical Center (LUMC) Department of Pathology shows the power of artificial intelligence (AI) applied to endometrial carcinoma microscopy images. The group of Dr. Tjalling Bosse offers novel insights that could improve diagnosis and treatment of uterine cancer. Their…

Philosophy alumna Naomi Rebekka Boekwijt returns to Leiden University on 20 June to present her latest novel Stemmen (Voices) in Plexus. ‘I wanted to show that things could be done differently in psychiatric care.’

As part of the HTSM2017 funding program, the LACDR division for Systems Biomedicine and Pharmacology received 1.08 million euros for a research project to develop novel engineering approaches to fight cancer.

The Department of Medical Microbiology at Leiden University Medical Center (LUMC) is researching antiviral drugs that could treat and prevent SARS-CoV-2 in various projects. One part of the PanCoroNed project is being led by Martijn van Hemert and involves lab tests into the antiviral effect of molecules…

Using biomethane to produce ammonia, a crucial chemical in agriculture, could drastically reduce the climate impact of the process. In a study published in One Earth, researcher Robert Istrate shows it’s even possible to make ammonia production net-zero or carbon negative.

Vaccination is the most effective method to prevent influenza infection. However, current influenza vaccines have several limitations. Relatively long production times, limited vaccine capacity, moderate efficacy in certain populations and lack of cross-reactivity are important issues that need to be…

Lecture, Seminar

The mission in this division, headed by Laura Heitman, is to design and synthesize novel and better ligands for drug targets. Drug discovery is a lengthy but inspiring adventure. It is often an interplay between academic institutes and pharmaceutical industry, in which scientists at university develop…

PhD defence

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

The research area of this division is focused on the development of novel therapeutic modalities and novel concepts in early drug discovery, in order to better predict ligand-target interactions.

In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…

An overview of research themes and projects at ABS.

In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

Every month a member of the Institute for History tells about a book that inspired him or her. Afterwards, the pen is passed on to another colleague. This month dr. Meike de Goede tells about the book 'Between Tides' by Valentin Mudimbe. The novel, little known beyond the circles of Africanists and…

Assessing and implementing new diagnostics strategies for stratifying patients

Promotor: Prof.dr. T. Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Quantum computing is a novel paradigm for computation, which is nearing real-world impact with the coming generation of limited, but nonetheless powerful quantum devices.

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

How to stimulate novel research in science and innovation

Grants awarded to molecular physiology research

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.