The Center for Interdisciplinary Placebo Studies Leiden (IPS) aims to advance the understanding of placebo and nocebo effects, their underlying mechanisms, and their potential applications in clinical practice. IPS consists of a group of interdisciplinary researchers working at Leiden University with…

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Researchers from the Leiden University Medical Center (LUMC) have successfully used stem cell gene therapy to treat a baby with the severe congenital immune disorder SCID. An important milestone: it is the first time stem cell gene therapy of Dutch origin has been administered to a patient, and also…

Funded by a ZonMw grant, the LUMC and the Health Campus The Hague will be working with headache patients on research into the use of an electronic headache diary. This resource can help patients gain a better understanding of their migraine attacks and, together with the physician, produce the best…

Migraine can’t be diagnosed with a blood test, scan or physical examination. Language therefore plays a crucial role in its diagnosis. Neurologist Joost Haan has researched the relationship between language and migraine, and looked at how migraine is described in fiction. His PhD defence is on 22 Oc…

Professor of Radiology Lioe-Fee de Geus-Oei was already a professor at LUMC and the University of Twente. As Medical Delta professor, she has now also been appointed at Delft University of Technology. 'Talking with people from other disciplines always makes me immensely humble, because they look at…

Source: Journal of Investigative Dermatology, Volume 135, pp. S59-S59 (2015)

Leiden University is involved in five new NWO Gravitation projects. Two relate to mental disorder and the remaining three to a healthy lifestyle, the combination of human and artificial intelligence, and the special relationship between plants and microbes.

The BENEFIT programme is a public-private ecosystem in a national consortium, aiming to support patients with cardiovascular diseases in their own home setting for a long-term healthy lifestyle.

This project investigates ethnographically how patients, their relatives, and healthcare professionals in the Netherlands make decisions about end-of-life care. We study the new dilemmas around what constitutes

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The ambition of the Metabolomics and Analytics Centre led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies on the…

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

'Community Involvement in Conservation and Livelihood Initiatives in the Eastern Himalayas Reflections on Practices and Policies' is a critical reflection written by academic and societal partners included in the Futuring Heritage project consortium, published by the Integrated Mountain Initiative (IMI)…

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Lifelong learning | “Even though we were spread across five continents, there was a strong sense of connection.”

This article aims to contribute to the debate about citizen involvement in medical and social issues by studying co-production initiatives in The Hague.

Helping cancer patients with treatment choices.

Archaeologist Maikel Kuijpers participated in the development of the boardgame Epoch: Early Inventors. “This game is inspired by the major innovation that happened in prehistoric times. A topic that has my interest and that I teach here in Leiden.

Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.

How do dissociative states affect the ability to suppress emotional distraction (in the context of a working memory task) in patients with Borderline Personality Disorder?

Information obtained from Czech intelligence authorities has shown that politicians from several European countries, including the Netherlands, are involved in a Russian bribery scandal. Wim Voermans, Professor of Constitutional Law, comments on this in Dutch newspaper ‘NRC’.

The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We work on clinical problems that require further mechanistic understanding and strive for ultimate benefit to patients.

Knowledge on how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically-ill patients, is not only crucial for novel compounds, but also for existing drugs which are often used in an off-label manner in these special patient…

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

A new therapy for the serious Graft-versus-Host disease

The United Nations has chosen The Hague as the location for a new data centre for humanitarian aid. Leiden University is involved in developing the digital knowledge to be used by the centre.

Persistent somatic symptoms are long term symptoms that lack a clear medical explanation. These symptoms have a high prevalence where most people know someone who experiences such symptoms or they experience such symptoms themselves. Symptoms can vary greatly in and between people. While one person…

Researcher and lecturer Susana Valdez investigates how migrants make use of online translation technology in medical situations. Her research suggests that they often encounter obstacles when using machine translation in these settings. Potential problems include a lack of understanding or trust.

What are the most important perpetuating factors of chronic fatigue and chronic fatigue syndrome, and which interventions are effective in influencing these factors?

Previous research has found important inter-individual differences in the pharmacokinetics (PK) of morphine in special populations such as children, the morbidly obese or the critically ill.

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Assessing and implementing new diagnostics strategies for stratifying patients

In 2020, Leiden University launched its stimulated interdisciplinary programs, including one focused on regenerative medicine.

Searching for ways to delay the need for a transplant and trying to build kidneys to order.

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.

We study how communication can heal and harm when patients are confronted with an illness. Most of our studies focus on serious illnesses such as advanced cancer. Communication lies at the heart of medicine, yet we do not always know which specific communication helps patients. Moreover, many complaints…

Treatment and care for cancer patients is becoming increasingly advanced. For example, surgeons can now perform operations with much greater precision, and therapeutic vaccines are being developed to prompt the patient’s immune system to fight cancer. Work is also being done on better early diagnostics,…

In the specialisation Clinical Neuropsychology, part of the Master in Psychology, you will focus on fostering clinical and scientific skills based on a solid theoretical background as well as practical training in neuropsychology and (clinical) neuropsychological research.

In order to optimize treatment, it is necessary to closely monitor and manage the patient’s health status by means of ‘precision diagnostics, personalized prognosis and targeted therapy’. The specialisation combines the techniques and applications of these sensing (monitoring) and stimulation techniques.…

The research conducted at the Health, Medical and Neuropsychology unit investigates the psychological factors of health and disease, which allows for the development of innovative treatments.

Having a chronic somatic condition can result in a variety of impairments in patients’ daily lives, including not only physical complaints such as pain, itch, and fatigue, but also problems of negative mood and impairments in social relationships. Next to disease characteristics, individual difference…

In case of serious illness, treatment in the Intensive Care Unit (IC) may be necessary. Intensive care treatments has improved over the years and more and more seriously ill patients are surviving admission to the ICU. This favorable development however has a downside since long-term consequences of…

The research of this PhD project can be subdivided into two main disease areas: migraine and stroke. For both we will be investigating how artificial intelligence (AI) and machine learning (ML) techniques can be used to study these afflictions, their (early) detection, and their potential treatment.

This article presents an evidence-based investigation of spontaneous hospitalization and distribution of patients after the Manchester terrorist attack.