Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Several single-stranded RNA viruses make use of Xrn1-resistant RNAs in their 3’ untranslated regions of their genome RNAs in order to increase their pathogenicity.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

Source: J Med Chem (2015)

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

CML report 192

Stellar feedback is a crucial ingredient in the evolution of galaxies.

Planets are formed in disks of gas and dust around young stars.

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)

The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny…

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

PhD at Leiden University and Bruker - the Netherlands

Promotores: Prof.dr. A.G.G.M. Tielens & Prof.dr. L. Kaper (UvA)

In this thesis, we present new laboratory data of interstellar dust analogues.

Source: Mediators Inflamm (2014)

Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi

Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.

Metabolomics group, LCQUI, Universidade UENF, Campos dos Goytacazes/Rio de Janeiro - Brazil

Promotores: G.W. Canters, T.J. Aartsma

The Graduate School of Science offers 9 PhD programmes, spanning the entire spectrum of science. Do you have a Master's degree and are you proficient in English? Do you share a fascination for science? Then you may find the Graduate School of Science an inspiring and ideal environment for obtaining…

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

Source: Eur J Med Chem, Volume 101, pp. 681-91 (2015)

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Both the Dutch government and the European Commission dedicate an increasing share of public funding for research and innovation to mission-oriented programs, aiming to facilitate sustainability transitions. These programs typically involve support fora range of different research activities, from the…

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

This thesis discusses several questions regarding the double ramification cycle as a Chow class on the moduli space of stable n-pointed genus g curves using tools from so-called logarithmic geometry.

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

Developing new medicines is one of modern science's most significant hurdles, a process marked by high costs, long timelines, and frequent failures of promising candidates.

Promotor: Prof.dr. J. Brouwer, Co-promotor: Dr. Remus Th. Dame

Research in the Lars Jeuken group focusses on redox-active proteins and membranes enzymes, aiming to understand bacterial respiration at the molecular level for the development of antimicrobials and semi-artificial photo-synthetic cells.

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

The aromatic infrared bands (AIBs) seen throughout the interstellar medium (ISM) are generally thought to be carried by polycyclic aromatic hydrocarbons (PAHs) and their nitrogen analogues (PANHs).

Promotor: Prof.dr. A.G.G.M. Tielens, Co-Promotor: J.B.R. Oonk

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

This thesis is about the study of hydrocarbons via infrared spectroscopy.