2,968 search results for “binding study advice bsa” in the Public website
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Chemical biology of glucosylceramide metabolism: fundamental studies and clinical applications for Gaucher disease
How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?
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Crewe WilliamsFaculty of Humanities
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Synthesis and applications of cell wall glycopolimer fragments from Staphilococci and Enterococci
Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…
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Judith FrishmanFaculty of Humanities
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Arie van der KooijFaculty of Humanities
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A listening ear and advice that fits the situation
For several months now, in addition to her responsibilities as Institute Manager for the Academy of Creative and Performing Arts (ACPA), Rosalien van der Poel has been fulfilling a different role: that of confidential adviser to doctoral candidates. ‘It’s an honour to be able to do this work,’ Rosalien…
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Mirjam Sombroek asked by Minister of Health for urgent advice on vaccination of children
Associate Professor Mirjam Sombroek has been asked for advice on account of her expertise in the area of health law and children’s rights.
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Executive Board of the University asks University Council for advice on activating person counters/sensors
The Executive Board of Leiden University has asked the University Council to advise on its proposed decision to reactivate the person counters/sensors in due course. The Council will now look at this carefully before the Board makes a final decision. The advice of the University’s participation body…
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Paula Esteves dos Santos JordaoFaculty of Humanities
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Staff symposium on student well-being: ‘Building on a healthy, engaged and learning community’
Over 200 staff from Leiden University discussed student well-being with one another and students at the Staff Symposium on Student Well-being. In various workshops and lectures, lecturers, student advisers, student counsellors and other staff members discussed how they could contribute to our students’…
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Sarah HolmaFaculty of Humanities
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Marat MarkertFaculty of Humanities
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Léon BuskensFaculty of Humanities
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Irene HadiprayitnoFaculty of Humanities
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Agonists for the Adenosine A1 Receptor with Tunable Residence Time. A Case for Nonribose 4-Amino-6-aryl-5-cyano-2-thiopyrimidines
Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)
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Christian HendersonFaculty of Humanities
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Congruence between voters and parties: The role of party‐level issue salience
The level of congruence between parties and their voters can vary greatly from one policy issue to another, which raises questions regarding the effectiveness of political representation. We seek to explain variation in party–voter congruence across issues and parties.
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'I really like it that our advice is taken seriously by the organisation'
Writing a report for a teacher, getting a grade and then no one ever cares about your research again. Pity, isn't it? That is quite different in the course Personal and Professional Impact (PPI). During this third-year bachelor's course of Cultural Anthropology students apply their anthropological knowledge…
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Allosteric Modulation
Allosteric modulation has long been recognized as a general and widespread mechanism for the control of protein function. Modulators bind to regulatory sites distinct from the active site on the protein, resulting in conformational changes that may profoundly influence protein function. This concept…
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Pilar Jimenez GalindoFaculty of Humanities
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Al Al FarabiFaculty of Law
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Tim WuismanFaculty of Governance and Global Affairs
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Maria RiepFaculty of Archaeology
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allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action
Source: Mediators Inflamm (2014)
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Jelle BruningFaculty of Humanities
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Kinetics for Drug Discovery: a Case for the Adenosine A3 receptor
Supervisor: Lizi Xia
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Kinetic profiling of positive allosteric modulators of the mGlu2 receptor
Supervisor: Maarten Doornbos
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Yujing TanFaculty of Humanities
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Guita WinkelFaculty of Humanities
- Asian Studies events
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University Council Elections 2025
With the University Council elections approaching, the Leiden University Green Office (LUGO), with the support of LU's Central Sustainability Team and the D&I Office, contacted all seven candidate parties to inform our community about their views on sustainability and diversity. We asked each party…
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Erik-jan ZurcherFaculty of Humanities
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Kiyan ForoutanFaculty of Humanities
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Hélène Nut
Faculty of Humanities
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Daný van DamFaculty of Humanities
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Bastian Still -
Mahmood YenkimalekiFaculty of Humanities
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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From every angle: novel insights into CC chemokine receptor 2 pharmacology
The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.
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Supercritical carbon dioxide spray drying for the production of stable dried protein formulations
Promotor: W. Jiskoot, Co-promotor: H.A. Every
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Michael HerzfeldSocial & Behavioural Sciences
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Author, Reader, Book: Medieval Authorship in Theory and Practice
This collection brings into conversation several kinds of scholarship on medieval authorship which have tended to remain separate over the last two to three decades, a period of steadily increasing scholarly interest in this topic.
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Shuqi JiaFaculty of Humanities
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Leiden Jewish Studies Network awards second 'Best Thesis in Jewish Studies'
This November, Leiden Jewish Studies Network has presented the Best Thesis in Jewish Studies award to a highly talented Leiden graduate, Lotte-Sofie Groenendijk, and awarded an honorable mention to Nasreen Javanjoo. The two theses stood out with their insightfulness and academic rigor among others written…
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Evolution of Molecular Resistance to Snake Venom α-Neurotoxins in Vertebrates
We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…
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Intracellular allosteric modulators for human CC chemokine receptors
Supervisor: Natalia Ortiz Zacarías
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Nathal DessingFaculty of Humanities
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Allosterism
The recognition that there may be more, so-called allosteric binding sites on a given receptor has also fueled our synthetic efforts. Over the last few years we have focused on many drug targets (adenosine A1, A2A and A3 receptors, the mGlu2 receptor and a classic ‘anti-target’, the hERG channel) to…
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Computational Drug Discovery
Research in this group, headed by Gerard van Westen, focusses on computational methods integrated in different parts of the drug discovery process. More specifically, topics include innovative treatments for cancer, selectivity modeling, translational research, allosteric modulation, drug resistance…
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Ali ShobeiriFaculty of Humanities