In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

'We believe that developing a protocol to help people fight cancer is extremely valuable, given that cancer is such a prevalent and devastating disease. If you believe so too, you can support us in realising this mission.' Master's student in Psychology Saskia Heijnen starts crowdfunding to make her…

PhD candidate Dennis Wander searches for the best of both worlds. That is to say: a cancer drug that is effective and also has minimal side effects. To this end, he makes new molecules inspired by two existing medicines. And not without result: ‘We have created a new variant that is very promising.’…

Leiden biophysicists have found a new possible way to attack cancer cells. They have located ‘sinkholes’ on the cells where receptor proteins disappear from the surface. If a drug could push these proteins towards those areas, it would kill the cancer cell.

PhD defence

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

This week we can vote in the University elections. The University Council and faculty councils are incredibly important. During the fantastic seminar on 50 years of participation that the University Council recently held, our former Rector Carel Stolker aptly said: ‘Without participation, there would…

This thesis investigates how cell shape and collective behavior influence the dynamics and structure of biological tissues, which are crucial for understanding processes like embryonic development, tissue regeneration, and metastasis.

Pharmaceutical research should make more use of data science, says Gerard van Westen, postdoctoral fellow at the Leiden Academic Centre for Drug Research (LACDR). ‘If we want to have better drugs, we should start with data.’

How can we translate more fundamental discoveries into clinical solutions for patients? From that question, the Oncode Accelerator programme emerged. Professor of Molecular Physiology Mario van der Stelt has been one of the driving forces behind it since its inception. In an interview on the website…

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

Promotor: Prof.dr. B. van de Water, Co-promotores: J.W. van der Laan, C.L.E. Siezen

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

On 23 April 2021, Professor Alfred Vertegaal from the Department of Cell and Chemical Biology at the Leiden University Medical Center (LUMC) delivered his inaugural lecture ‘Unraveling and exploiting cellular communication codes’. Vertegaal used the opportunity to describe how research in the field…

Research at the Leiden University Medical Center (LUMC) Department of Pathology shows the power of artificial intelligence (AI) applied to endometrial carcinoma microscopy images. The group of Dr. Tjalling Bosse offers novel insights that could improve diagnosis and treatment of uterine cancer. Their…

Marta Fiocco, professor in the Mathematical Institute, has received a grant for analysing data on chemotherapy in children suffering from leukaemia. The work involves developing and applying new statistical methods that will help determining the optimal dose of chemotherapy.

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

A new app is able to calculate personalised survival probabilities for patients suffering from soft tissue sarcoma. Doctors and patients can use the app to calculate personalised survival probabilities together. Mathematician Anja Rüten-Budde received her doctorate for her research into survival probability…

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Leiden University’s President of the Executive Board, Professor Annetje Ottow, has been reappointed for a second term by the Board of Governors.

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Promotores: Prof.dr. M.K. Richardson, Prof.dr. H.P. Spaink

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Thirty years ago, mutations in the BRCA1 gene were first linked to hereditary breast and ovarian cancer, establishing a genetic basis for cancer development.

Leiden University has a new Executive Board. Since 8 February 2021, Annetje Ottow has been the new President and Hester Bijl the new Rector Magnificus of the Board, while Martijn Ridderbos has continued in his role as Vice-Chairman.

ChatGPT, the text-generating chatbot, has recently become available for anyone to use. Is this artificial intelligence (AI) tool a threat to our teaching?

This is a difficult time. Above all, for all those directly involved in this horrible case – unacceptable behaviour by a professor and his removal from the University – the case we went public about on 18 October and that has been reported in the media. This is painful and tough for the complainants…

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

If we need funding for a project, equipment or research at the university, we automatically think of the Dutch Research Council or other grant providers. But more and more researchers are managing to connect with people who care about the university.

Several Dutch universities have said they do not want foreign student numbers to grow any more in some of their degree programmes. They are reaching maximum capacity. We are also alert to this in Leiden, but I see many positive aspects to the intake of international students.

We asked a lot of everyone last year. The Personnel Monitor showed that the workload was high in 2022 and Covid took its toll. I therefore think everyone deserves some downtime. Time away from the daily grind.

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

The rising energy prices cannot have escaped anyone’s notice. They have dominated the news in recent months. As a university, we too face a big challenge as the prices continue to rise. We will all have to do our bit in the coming months, also in view of the climate crisis that we want to help resol…

I was disgusted by the recent Ongehoord Nederland broadcast on 15 September. The racist and hateful comments made by alumna Raisa Blommesteijn were, as far as I am concerned, way over the line and in my opinion also violate Article 1 of the Constitution of the Netherlands.

The more than 370 sensors that have been hung up in Leiden University buildings to count the people present will not be switched on again. The equipment will eventually be removed from the buildings.

Now the introduction weeks can go ahead as usual, the new students’ enthusiasm is overwhelming. It’s back to normal for the student associations too, having had a hard time of it during the pandemic.

Leiden University is a fantastic example of a network university: we create an impact with the city, stakeholders and regional and international partners. The lines of communication are really short and there is a great sense of togetherness. Our good relations with the city have also informed how we…

For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…

I recently went to the anniversary celebration of The Meeting Point, and the stories the refugee students told made a huge impression on me. The Meeting Point helps students from different backgrounds feel part of our university community.