According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Lipsius, Cleveringaplaats 1, 2311 BD, Leiden

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

The Faculty of Law

The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.

The Collective Experience of Empathic Data Systems (CEEDs) consortium developed novel integrated technologies that support experiencing, analysing and understanding of very large datasets.

Research into research improves the academic system. CWTS studies and evaluates the academic system in various ways. One way is to provide information on the productivity and impact of academics by documenting how many publications they or their universities produce and how often these publications…

Issues such as climate change, the depletion of natural resources or social inequality are too complex to be addressed from a single scientific discipline or by a single country. Leiden University has the expertise to bring the resolution of these enormous problems a small step closer.

The complexity of an intelligence problem determines to a great extent the certainty that can be provided by intelligence and security services.

This dissertation examines the European Union’s response to the growing problem of disinformation. It uses this case to critically analyse how societies interpret and manage information challenges such as ‘fake news’ and propaganda.

Promotor: J.N. Kok, Co-promotor: H.J. Hoogeboom

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

Promotor: E. Bouwman Co-Promotor: S. Bonnet

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth

Anthropologist Marja Spierenburg talks in the Dutch newspaper NRC about the neoliberal system and how it has to change in order to solve the energy crisis in South-Africa.

To what extent is the legislation and use of pre-trial detention of juveniles in the Netherlands in compliance with international children’s rights standards?

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Researchers at LIACS are working to devise the computers of tomorrow that will be the backbone of the Cloud and Edge computing paradigms as well as the Internet of Things. In this respect, we are involved in research and development of high performance computing systems, embedded & real-time computing…

My ERC Starting Grant, funded with €1.5 million for 5 years as part of the Horizon 2020 research and innovation program, is focused on building the early warning system WARN-D to reliably forecast depression in young adults before it occurs. Why depression, and why prediction?

Dynamical systems describe the evolution of objects in a space over time and may be used to model physical phenomena. Due to this, much research is dedicated to understanding the mathematics of dynamical systems.

Promotor: Prof.dr. M. Ubbink

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

Calamus javensis is polymorphic. Morphometry and molecular approach resulted in all names used in the complex are regarded as synonyms of C. javensis except C. tenompokensis, which is retained as a distinct species. One variety is here recognized, C. javensis var. polyphyllus (including C. acuminatu…

This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).

Here are some systems and infrastructures that are useful to students.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

This is the first special issue of any organisation studies journal on food labour. Why is this a big deal? In this Introduction, we argue that the field should pay much more attention to the agri-food system and the work that goes into producing, distributing and consuming foodstuff. Food is such an…

Immunologist Leender Trouw specialises in the complement system, which is part of the immune system. In some diseases drugs help activate or inhibit this system. This is best done ‘in the right place at the right time’ − the title of his inaugural lecture.

This project develops methods for ensuring the anonymity of individuals in social network data.

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

Dutch coalition parties VVD and CDA want to tighten asylum policy and have launched a plan to grant two types of statuses to refugees. They also intend to partially restrict the right to family reunification. However, this plan is facing strong opposition. With the proposal, the government can expect…

Every year, Leiden University welcomes some 27,000 students from 115 different countries. In educating these students, we are committed to ensuring that the quality of our tuition meets or exceeds the highest-possible standards.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

I will give a general introduction to the field of molecular electronics, its history, methods and challenges. I will also introduce the subject of my investigation and provide a brief outlook to the remainder of our thesis.

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

The correctness of computational systems is of great importance to our society, since it becomes ever more reliant on the benefits of computing.

In autoimmune diseases such as rheumatism and diabetes the immune system attacks autologous proteins. Leiden researchers are trying to discover how this comes about.

Making systems biology modelling a central pillar of research in biology

How do balanced lethal systems originate and persist in nature?

The research of our group is centered around dynamical systems, functional analysis and their interplay.

Imagine getting a notification on your mobile phone with your personal code for impending mental health problems or even depression: yellow, orange, or red. Science fiction? Not for scientist Eiko Fried. 'There is a real chance we can prevent some mental health problems before they occur.' Want to participate…

Students in Leiden are entitled to good teaching and good supervision. For their part, there are some conditions they have to meet to ensure that they complete their studies within the time allotted.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

Is system thinking through perspectives the solution for biology education to help students see the connections between different topics?

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen