601 search results for “mathematisch biology” in the Public website
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Madeline KavanaghFaculty of Science
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Uniform infinite and Gibbs causal triangulations
Promotor: Richard D. Gill
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Teachers’ practical knowledge and lesson design in the context of innovation
This project is situated within the context of an innovation of the biology curriculum in Dutch secondary schools. The main purposes are (1) to clarify the relation between teachers’ practical knowledge and the decisions they make when planning and implementing their lessons and (2) to develop a professional…
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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Han de WindeFaculty of Science
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar
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Han van KonijnenburgFaculty of Science
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Niels van der WindtFaculty of Science
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The tension between nature conservation and economic valuation of ecosystem services
Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters
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Jitske van WelsenFaculty of Science
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Thiosugars: reactivity, methodology and applications
Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…
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Peptide amphiphiles and their use in supramolecular chemistry
Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros
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Linking the gene regulatory network with the functional physical structure of whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.
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Breaking the Unbreakable: Computational and Biochemical Identification of Polyethylene-Degrading Enzymes
Engineering an efficient microbial enzymatic polyethylene degradation pathway via an innovative combination of biochemistry and computational biology tools for enzyme discovery and characterization.
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Karline JanmaatSocial & Behavioural Sciences
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Hybrid zone dynamics in amphibians
Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.
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Michael RichardsonFaculty of Science
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Cum laude PhD defence: natural seed bank drives diversity
Each year, poppies disperse seeds that grow into a new generation of flowers. Sometimes, some of the seeds postpone their germination for a few years, for example when they’re covered by a layer of sand. Only when the sand disappears, do they start to sprout. Margriet Oomen did mathematical research…
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Molecular Biology for Physics will NOW start on Monday 5 February!
Please note that the course Molecular Biology for Physics will start on Monday 5 February. Please check the schedules for the time and location!
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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Microbial enzymes for degradation and upcycling of natural and non-natural polymers
Learning from nature and utilizing microbial biodiversity to identify and characterize enzymes for degradation and upcycling of plastics and other polymeric materials.
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Genetic pollution
How does invasive hybridization affect threatened native species?
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Inhibitors and probes targeting mannanases
This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…
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Leiden University strengthens its focus on Chemical Biology and Medicinal Chemistry with seven new group leaders
Tackling key challenges of Chemical Biology and Medicinal Chemistry to aid drug discovery is one of the focus areas of Leiden University. To this end, the Leiden Early Drug Discovery & Development network (LED3) was established by the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden…
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Sandra IrmischFaculty of Science
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Anthe JanssenFaculty of Science
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Meindert LamersFaculty of Science
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Erik van Kampen publishes in the Journal of Leukocyte Biology: The effects of poor eating habits persist even after diet
New research published in the Journal of Leukocyte Biology suggests that these changes to the behavior of the immune system are persistent and can continue even after diet is improvedAlmost everyone knows that improving your eating habits will most likely improve your health. What most people may not…
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Tackling messy blood vessels to fight cancer
With a Vici grant of 1.5 million euros, Professor of Mathematical biology Roeland Merks will look for ways to fix messy and leaky blood vessels in tumours. His research combines mathematical simulations and lab experiments in a unique way.
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Stress-induced protein dynamic and growth arrest in C. elegans during development
During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).
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Evolutionary molecular dynamics
This thesis introduces the concept of
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Merijn de BakkerFaculty of Science
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Paul KesslerFaculty of Science
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Esther van der EntFaculty of Science
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Metabolic signatures in nutrition and health: short-term diet response, sexual dimorphism and hormone chronobiology
The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).
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Chemical Tools to Illuminate N-acylphosphatidylethanolamine Biosynthesis
This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.
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Systems diagnosis in chronic disease: prediction and evaluation
Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen
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Roeland MerksFaculty of Science
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Berend GagesteinFaculty of Science
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Roderick BoumanFaculty of Science
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Evolutionary diversification and historical biogeography of Orchidaceae in Central America with emphasis on Costa Rica and Panama
In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.
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Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
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MOOC ‘Evolution Today’
Evolution is all around you every day. This is the message of a Massive Open Online Course (MOOC) of Leiden University and Naturalis that is offered free of charge to anyone interested.
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MARBLES - Marine Biodiversity as Sustainable Resource of Disease-Suppressive Microbes and Bioprotectants for Aquaculture and Crop Diseases
To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.
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Illuminating N-acylethanolamine biosynthesis with new chemical tools
In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.
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Ewa Snaar-JagalskaFaculty of Science
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Tressia ChikodzaFaculty of Science
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Neeltje BlankensteinSocial & Behavioural Sciences
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Hermen OverkleeftFaculty of Science