Promotor: G.P. van Wezel, Co-promotor: D. Claessen

'Community Involvement in Conservation and Livelihood Initiatives in the Eastern Himalayas Reflections on Practices and Policies' is a critical reflection written by academic and societal partners included in the Futuring Heritage project consortium, published by the Integrated Mountain Initiative (IMI)…

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Lifelong learning | “Even though we were spread across five continents, there was a strong sense of connection.”

This article aims to contribute to the debate about citizen involvement in medical and social issues by studying co-production initiatives in The Hague.

'It gave our team a big boost to hear that our work was valuable,' says medical chemist Elmer Maurits about the moment they won the Venture Challenge. With their company Iprotics, they want to develop a drug that can better treat patients with autoimmune diseases and blood cancers. 25,000 euros of prize…

Despite the promising effects of technology in assessment and treatment, the actual use of novel technologies in juvenile justice context remains limited. We want to inspire researchers to develop and investigate technological applications for assessment and treatment for justice involved youth.

Helping cancer patients with treatment choices.

Archaeologist Maikel Kuijpers participated in the development of the boardgame Epoch: Early Inventors. “This game is inspired by the major innovation that happened in prehistoric times. A topic that has my interest and that I teach here in Leiden.

Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.

How do dissociative states affect the ability to suppress emotional distraction (in the context of a working memory task) in patients with Borderline Personality Disorder?

Information obtained from Czech intelligence authorities has shown that politicians from several European countries, including the Netherlands, are involved in a Russian bribery scandal. Wim Voermans, Professor of Constitutional Law, comments on this in Dutch newspaper ‘NRC’.

The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We work on clinical problems that require further mechanistic understanding and strive for ultimate benefit to patients.

Local perceptions, attachments and knowledge are often not considered in the methodology of archaeology when researching a site, argues PhD-candidate Tomomi Fushiya. She proposes a broader integration of local perceptions in an archaeological narrative. PhD-defence on December 2.

Knowledge on how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically-ill patients, is not only crucial for novel compounds, but also for existing drugs which are often used in an off-label manner in these special patient…

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

A new therapy for the serious Graft-versus-Host disease

This year, two Leiden master students will be awarded a KNMP Student Award. Both Wisse van Os and Jip Linthorst will receive 1,000 euros from the Royal Dutch Pharmacists Association (KNMP) as a reward for their excellent study results, motivation and commitment.

The United Nations has chosen The Hague as the location for a new data centre for humanitarian aid. Leiden University is involved in developing the digital knowledge to be used by the centre.

Persistent somatic symptoms are long term symptoms that lack a clear medical explanation. These symptoms have a high prevalence where most people know someone who experiences such symptoms or they experience such symptoms themselves. Symptoms can vary greatly in and between people. While one person…

Researcher and lecturer Susana Valdez investigates how migrants make use of online translation technology in medical situations. Her research suggests that they often encounter obstacles when using machine translation in these settings. Potential problems include a lack of understanding or trust.

What are the most important perpetuating factors of chronic fatigue and chronic fatigue syndrome, and which interventions are effective in influencing these factors?

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

Previous research has found important inter-individual differences in the pharmacokinetics (PK) of morphine in special populations such as children, the morbidly obese or the critically ill.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Assessing and implementing new diagnostics strategies for stratifying patients

Via expedited proceedings at Leeuwarden Court of Appeal, a mother is trying to impose a relatively new treatment for her 15-year-old daughter’s eating disorder. The girl is suffering from anorexia nervosa and if she does not receive urgent treatment which the girl herself supports, there is a chance…

In 2020, Leiden University launched its stimulated interdisciplinary programs, including one focused on regenerative medicine.

Searching for ways to delay the need for a transplant and trying to build kidneys to order.

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.

We study how communication can heal and harm when patients are confronted with an illness. Most of our studies focus on serious illnesses such as advanced cancer. Communication lies at the heart of medicine, yet we do not always know which specific communication helps patients. Moreover, many complaints…

Treatment and care for cancer patients is becoming increasingly advanced. For example, surgeons can now perform operations with much greater precision, and therapeutic vaccines are being developed to prompt the patient’s immune system to fight cancer. Work is also being done on better early diagnostics,…

In the specialisation Clinical Neuropsychology, part of the Master in Psychology, you will focus on fostering clinical and scientific skills based on a solid theoretical background as well as practical training in neuropsychology and (clinical) neuropsychological research.

In order to optimize treatment, it is necessary to closely monitor and manage the patient’s health status by means of ‘precision diagnostics, personalized prognosis and targeted therapy’. The specialisation combines the techniques and applications of these sensing (monitoring) and stimulation techniques.…

The research conducted at the Health, Medical and Neuropsychology unit investigates the psychological factors of health and disease, which allows for the development of innovative treatments.

Having a chronic somatic condition can result in a variety of impairments in patients’ daily lives, including not only physical complaints such as pain, itch, and fatigue, but also problems of negative mood and impairments in social relationships. Next to disease characteristics, individual difference…

In case of serious illness, treatment in the Intensive Care Unit (IC) may be necessary. Intensive care treatments has improved over the years and more and more seriously ill patients are surviving admission to the ICU. This favorable development however has a downside since long-term consequences of…

The research of this PhD project can be subdivided into two main disease areas: migraine and stroke. For both we will be investigating how artificial intelligence (AI) and machine learning (ML) techniques can be used to study these afflictions, their (early) detection, and their potential treatment.

This article presents an evidence-based investigation of spontaneous hospitalization and distribution of patients after the Manchester terrorist attack.

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. D. Tibboel (EMC, R’dam)

The Quantitative Clinical Pharmacology group is led by Prof. Dr. Catherijne Knibbe. Her research group aims to define how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically ill patients. Through combining the statistical…

Collecting as much information as possible about administering a new medicine to people can save a lot of money.

Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…

Psychological processes have a major effect on the course of a disease and the effects of medical treatment. Researchers in the field of Psychoneurobiology examine the interactions between body and mind. They investigate the effects of stress as well as the effect of placebos and nocebos, which can…

Half of all people with cancer in the Netherlands are aged 70 or older, and as the population continues to age, this number will only rise. Yet vulnerable older people with cancer are often overlooked, says PhD candidate Joosje Baltussen.